Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease
Monoclonal gammopathy of renal significance (MGRS) comprises a spectrum of kidney manifestations distinguished by its clinical and pathological presentations. This article reports a case of a female on her 60s who was referred to Nephrology for evaluation of worsening kidney function, hematuria, and...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-03-01
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| Series: | Kidney Medicine |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590059524001754 |
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| author | Silvia M. Titan Sandra Herrmann Nelson Leung Pingchuan Zhang Stephen Ansell |
| author_facet | Silvia M. Titan Sandra Herrmann Nelson Leung Pingchuan Zhang Stephen Ansell |
| author_sort | Silvia M. Titan |
| collection | DOAJ |
| description | Monoclonal gammopathy of renal significance (MGRS) comprises a spectrum of kidney manifestations distinguished by its clinical and pathological presentations. This article reports a case of a female on her 60s who was referred to Nephrology for evaluation of worsening kidney function, hematuria, and proteinuria. Her medical history was notable for marginal zone lymphoma along with immunoglobulin M (IgM)-kappa cold agglutinin disease diagnosed 3 years before the current presentation, which had been treated with rituximab. A kidney biopsy was performed and revealed IgM-kappa monoclonal protein-associated nephropathy with predominantly intracapillary monoclonal IgM deposition injury pattern, a rare form of MGRS, reported for the first time in association with cold agglutinin disease. |
| format | Article |
| id | doaj-art-d87bd314279041989c96eec9ee93f01f |
| institution | Kabale University |
| issn | 2590-0595 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Kidney Medicine |
| spelling | doaj-art-d87bd314279041989c96eec9ee93f01f2025-01-30T05:14:50ZengElsevierKidney Medicine2590-05952025-03-0173100964Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin DiseaseSilvia M. Titan0Sandra Herrmann1Nelson Leung2Pingchuan Zhang3Stephen Ansell4Nephrology and Hypertension Division, Department of Internal Medicine, Mayo Clinic, Rochester, MN; Address for Correspondence: Silvia M. Titan, MD, PhD, 200 First Street SW, Rochester, MN 55902.Nephrology and Hypertension Division, Department of Internal Medicine, Mayo Clinic, Rochester, MNNephrology and Hypertension Division, Department of Internal Medicine, Mayo Clinic, Rochester, MNLaboratory Medicine and Pathology Department, Mayo Clinic, Rochester, MNHematology Division, Department of Internal Medicine, Mayo Clinic, Rochester, MNMonoclonal gammopathy of renal significance (MGRS) comprises a spectrum of kidney manifestations distinguished by its clinical and pathological presentations. This article reports a case of a female on her 60s who was referred to Nephrology for evaluation of worsening kidney function, hematuria, and proteinuria. Her medical history was notable for marginal zone lymphoma along with immunoglobulin M (IgM)-kappa cold agglutinin disease diagnosed 3 years before the current presentation, which had been treated with rituximab. A kidney biopsy was performed and revealed IgM-kappa monoclonal protein-associated nephropathy with predominantly intracapillary monoclonal IgM deposition injury pattern, a rare form of MGRS, reported for the first time in association with cold agglutinin disease.http://www.sciencedirect.com/science/article/pii/S2590059524001754Cold agglutinin diseasegammopathyglomerulonephritismarginal cell lymphomamonoclonalrenal failure |
| spellingShingle | Silvia M. Titan Sandra Herrmann Nelson Leung Pingchuan Zhang Stephen Ansell Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease Kidney Medicine Cold agglutinin disease gammopathy glomerulonephritis marginal cell lymphoma monoclonal renal failure |
| title | Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease |
| title_full | Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease |
| title_fullStr | Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease |
| title_full_unstemmed | Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease |
| title_short | Intracapillary Monoclonal IgM Deposition Concomitant With Cold Agglutinin Disease |
| title_sort | intracapillary monoclonal igm deposition concomitant with cold agglutinin disease |
| topic | Cold agglutinin disease gammopathy glomerulonephritis marginal cell lymphoma monoclonal renal failure |
| url | http://www.sciencedirect.com/science/article/pii/S2590059524001754 |
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