Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study
IntroductionMalnutrition is associated with increased morbidity and mortality from multiple diseases. However, the relationship between cerebral small vessel disease (CSVD) and malnutrition or malnutrition risk remains underexplored. This retrospective study investigated the association between maln...
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Neurology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fneur.2025.1512109/full |
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| author | Junyi Liu Junyi Liu Junyi Liu Jie Lin Jie Lin Jie Lin Jieying Zhuang Jieying Zhuang Jieying Zhuang Qian Luo Qian Luo Qian Luo Huijuan Wang Huijuan Wang Huijuan Wang Ruiyan Xiao Ruiyan Xiao Ruiyan Xiao Xudong Yang Xudong Yang Xudong Yang Jiangping Cai Jiangping Cai Jiangping Cai |
| author_facet | Junyi Liu Junyi Liu Junyi Liu Jie Lin Jie Lin Jie Lin Jieying Zhuang Jieying Zhuang Jieying Zhuang Qian Luo Qian Luo Qian Luo Huijuan Wang Huijuan Wang Huijuan Wang Ruiyan Xiao Ruiyan Xiao Ruiyan Xiao Xudong Yang Xudong Yang Xudong Yang Jiangping Cai Jiangping Cai Jiangping Cai |
| author_sort | Junyi Liu |
| collection | DOAJ |
| description | IntroductionMalnutrition is associated with increased morbidity and mortality from multiple diseases. However, the relationship between cerebral small vessel disease (CSVD) and malnutrition or malnutrition risk remains underexplored. This retrospective study investigated the association between malnutrition risk and CSVD, along with its common imaging markers.MethodsA total of 806 participants from a neurology department underwent cranial MRI scans and nutritional assessments. The presence of imaging markers of CSVD, including white matter hyperintensities, lacune, perivascular spaces, and cerebral microbleeds, was evaluated by expert neurologists. Malnutrition risk was assessed using the Geriatric Nutritional Risk Index (GNRI) and Controlling Nutritional Status (CONUT) scores. Logistic regression, subgroup, and interaction analyses were performed to evaluate the associations between malnutrition risk, CSVD, and its common imaging markers.Results and discussionAfter adjusting for potential confounders, patients at risk of malnutrition, as identified by both the GNRI and CONUT scores, exhibited more severe CSVD and its common imaging markers. Further analyses revealed interactions between GNRI score and smoking, highlighting potential modifying effects on the relationship between malnutrition risk and CSVD. Collectively, malnutrition risk, as assessed by objective nutritional indices, is independently associated with CSVD and its common imaging markers. These results emphasize the importance of addressing malnutrition in the prevention and management of CSVD. |
| format | Article |
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| institution | Kabale University |
| issn | 1664-2295 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Neurology |
| spelling | doaj-art-d8750429c2d548c4b7e6cd291ec6ccab2025-08-20T03:31:07ZengFrontiers Media S.A.Frontiers in Neurology1664-22952025-06-011610.3389/fneur.2025.15121091512109Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional studyJunyi Liu0Junyi Liu1Junyi Liu2Jie Lin3Jie Lin4Jie Lin5Jieying Zhuang6Jieying Zhuang7Jieying Zhuang8Qian Luo9Qian Luo10Qian Luo11Huijuan Wang12Huijuan Wang13Huijuan Wang14Ruiyan Xiao15Ruiyan Xiao16Ruiyan Xiao17Xudong Yang18Xudong Yang19Xudong Yang20Jiangping Cai21Jiangping Cai22Jiangping Cai23The School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaThe School of Clinical Medicine, Fujian Medical University, Fuzhou, ChinaDepartment of Neurology, The First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, ChinaThe Graduate School of Fujian Medical University, Fuzhou, ChinaIntroductionMalnutrition is associated with increased morbidity and mortality from multiple diseases. However, the relationship between cerebral small vessel disease (CSVD) and malnutrition or malnutrition risk remains underexplored. This retrospective study investigated the association between malnutrition risk and CSVD, along with its common imaging markers.MethodsA total of 806 participants from a neurology department underwent cranial MRI scans and nutritional assessments. The presence of imaging markers of CSVD, including white matter hyperintensities, lacune, perivascular spaces, and cerebral microbleeds, was evaluated by expert neurologists. Malnutrition risk was assessed using the Geriatric Nutritional Risk Index (GNRI) and Controlling Nutritional Status (CONUT) scores. Logistic regression, subgroup, and interaction analyses were performed to evaluate the associations between malnutrition risk, CSVD, and its common imaging markers.Results and discussionAfter adjusting for potential confounders, patients at risk of malnutrition, as identified by both the GNRI and CONUT scores, exhibited more severe CSVD and its common imaging markers. Further analyses revealed interactions between GNRI score and smoking, highlighting potential modifying effects on the relationship between malnutrition risk and CSVD. Collectively, malnutrition risk, as assessed by objective nutritional indices, is independently associated with CSVD and its common imaging markers. These results emphasize the importance of addressing malnutrition in the prevention and management of CSVD.https://www.frontiersin.org/articles/10.3389/fneur.2025.1512109/fullcerebral small vessel diseasemalnutrition riskimaging markersgeriatric nutritional risk indexcontrolling nutritional status |
| spellingShingle | Junyi Liu Junyi Liu Junyi Liu Jie Lin Jie Lin Jie Lin Jieying Zhuang Jieying Zhuang Jieying Zhuang Qian Luo Qian Luo Qian Luo Huijuan Wang Huijuan Wang Huijuan Wang Ruiyan Xiao Ruiyan Xiao Ruiyan Xiao Xudong Yang Xudong Yang Xudong Yang Jiangping Cai Jiangping Cai Jiangping Cai Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study Frontiers in Neurology cerebral small vessel disease malnutrition risk imaging markers geriatric nutritional risk index controlling nutritional status |
| title | Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study |
| title_full | Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study |
| title_fullStr | Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study |
| title_full_unstemmed | Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study |
| title_short | Association between cerebral small vessel disease and malnutrition risk: a retrospective cross-sectional study |
| title_sort | association between cerebral small vessel disease and malnutrition risk a retrospective cross sectional study |
| topic | cerebral small vessel disease malnutrition risk imaging markers geriatric nutritional risk index controlling nutritional status |
| url | https://www.frontiersin.org/articles/10.3389/fneur.2025.1512109/full |
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