Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study
Purpose Inflammation, immune system and nutritional status contribute significantly to tumorigenesis, progression and metastasis. The aim of this study was to evaluate the significance of the inflammation-immune-nutritional score (IINS) on postoperative survival and recurrence in breast cancer patie...
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2025-08-01
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| author | Yuan Wang Wenxin Gao Shan Wang Jiajia Zhang Jiaru Zhuang Yibo Wu Xiaoyan Huang Jing He |
| author_facet | Yuan Wang Wenxin Gao Shan Wang Jiajia Zhang Jiaru Zhuang Yibo Wu Xiaoyan Huang Jing He |
| author_sort | Yuan Wang |
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| description | Purpose Inflammation, immune system and nutritional status contribute significantly to tumorigenesis, progression and metastasis. The aim of this study was to evaluate the significance of the inflammation-immune-nutritional score (IINS) on postoperative survival and recurrence in breast cancer patients and to analyze and compare the IINS, platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI) in terms of progression-free survival (PFS) and overall survival (OS) in patients with breast cancer (BC) who underwent surgical treatment prognostic value. Methods We executed a retrospective investigation of the clinical information and related materials of 200 female breast cancer patients who had their first breast cancer operation at the Affiliated Hospital of Jiangnan University between January 2017 and December 2018, and the IINS was built using the sum of preoperative categorical scores for high-sensitivity C-reactive protein (hs-CRP), lymphocytes (LYM), and albumin (ALB). In our survival analysis, we graphed the survival curves employing the Kaplan-Meier method. The effectiveness of pre-operative IINS, PLR, and PNI in PFS and OS of breast cancer patients were evaluated with receiver operating characteristic (ROC) curves and Cox proportional risk regression analyses. Results The median age of the patients was 55.5 years (range 34–75 years). In progression-free survival, the areas under the IINS, PLR, and PNI curves were as follows: IINS: 0.735, HR (95% CI) 0.037 [0.662–0.809], PLR: 0.724, HR (95% CI) 0.036 [0.655–0.794], PNI: 0.694, HR (95% CI) 0.038 [0.619–0.769]. In overall survival, the areas under the curves of IINS, PLR, and PNI were as follows: IINS: 0.738, HR (95% CI) 0.049 [0.642–0.834], PLR: 0.700, HR (95% CI) 0.039 [0.623–0.777], and PNI: 0.713 with HR (95% CI) 0.050 [0.615–0.811]. According to the findings, among patients with resectable breast cancer, preoperative IINS may be the most accurate indicator of both overall survival and progression-free survival. Conclusion IINS may be a dependable marker for predicting postoperative survival in patients with breast cancer, and its prognostic value may be higher than that of traditional markers. |
| format | Article |
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| institution | Kabale University |
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| spelling | doaj-art-d86ebf22760b4a92b0a01bf7a58efbba2025-08-24T15:05:06ZengPeerJ Inc.PeerJ2167-83592025-08-0113e1995010.7717/peerj.19950Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective studyYuan Wang0Wenxin Gao1Shan Wang2Jiajia Zhang3Jiaru Zhuang4Yibo Wu5Xiaoyan Huang6Jing He7Human Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, ChinaHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, ChinaHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, ChinaHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, ChinaHuman Reproductive and Genetic Center, Affiliated Hospital of Jiangnan University, Wuxi, ChinaDepartment of Histology and Embryology, School of Basic Medical Sciences, Nanjing Medical University, Nanjing, ChinaDepartment of Breast Surgery, Affiliated Hospital of Jiangnan University, Wuxi, ChinaPurpose Inflammation, immune system and nutritional status contribute significantly to tumorigenesis, progression and metastasis. The aim of this study was to evaluate the significance of the inflammation-immune-nutritional score (IINS) on postoperative survival and recurrence in breast cancer patients and to analyze and compare the IINS, platelet-to-lymphocyte ratio (PLR), and the prognostic nutritional index (PNI) in terms of progression-free survival (PFS) and overall survival (OS) in patients with breast cancer (BC) who underwent surgical treatment prognostic value. Methods We executed a retrospective investigation of the clinical information and related materials of 200 female breast cancer patients who had their first breast cancer operation at the Affiliated Hospital of Jiangnan University between January 2017 and December 2018, and the IINS was built using the sum of preoperative categorical scores for high-sensitivity C-reactive protein (hs-CRP), lymphocytes (LYM), and albumin (ALB). In our survival analysis, we graphed the survival curves employing the Kaplan-Meier method. The effectiveness of pre-operative IINS, PLR, and PNI in PFS and OS of breast cancer patients were evaluated with receiver operating characteristic (ROC) curves and Cox proportional risk regression analyses. Results The median age of the patients was 55.5 years (range 34–75 years). In progression-free survival, the areas under the IINS, PLR, and PNI curves were as follows: IINS: 0.735, HR (95% CI) 0.037 [0.662–0.809], PLR: 0.724, HR (95% CI) 0.036 [0.655–0.794], PNI: 0.694, HR (95% CI) 0.038 [0.619–0.769]. In overall survival, the areas under the curves of IINS, PLR, and PNI were as follows: IINS: 0.738, HR (95% CI) 0.049 [0.642–0.834], PLR: 0.700, HR (95% CI) 0.039 [0.623–0.777], and PNI: 0.713 with HR (95% CI) 0.050 [0.615–0.811]. According to the findings, among patients with resectable breast cancer, preoperative IINS may be the most accurate indicator of both overall survival and progression-free survival. Conclusion IINS may be a dependable marker for predicting postoperative survival in patients with breast cancer, and its prognostic value may be higher than that of traditional markers.https://peerj.com/articles/19950.pdfBreast cancerPrognosisInflammation-immunity-nutrition score (IINS)Platelet-lymphocyte ratio (PLR)Prognostic nutritional index (PNI)Progression-free survival |
| spellingShingle | Yuan Wang Wenxin Gao Shan Wang Jiajia Zhang Jiaru Zhuang Yibo Wu Xiaoyan Huang Jing He Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study PeerJ Breast cancer Prognosis Inflammation-immunity-nutrition score (IINS) Platelet-lymphocyte ratio (PLR) Prognostic nutritional index (PNI) Progression-free survival |
| title | Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study |
| title_full | Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study |
| title_fullStr | Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study |
| title_full_unstemmed | Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study |
| title_short | Significance of the inflammatory-immune-nutritional (IINS) score on postoperative survival and recurrence in breast cancer patients: a retrospective study |
| title_sort | significance of the inflammatory immune nutritional iins score on postoperative survival and recurrence in breast cancer patients a retrospective study |
| topic | Breast cancer Prognosis Inflammation-immunity-nutrition score (IINS) Platelet-lymphocyte ratio (PLR) Prognostic nutritional index (PNI) Progression-free survival |
| url | https://peerj.com/articles/19950.pdf |
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