Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs. The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium have anticomplementary activity and immunomodulatory functions on macrop...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Clinical and Developmental Immunology |
| Online Access: | http://dx.doi.org/10.1155/2012/842928 |
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| author | Yi-Wen Jiang Hong Li Yun-Yi Zhang Wen Li Yi-Fan Jiang Ying-Ye Ou Dao-Feng Chen |
| author_facet | Yi-Wen Jiang Hong Li Yun-Yi Zhang Wen Li Yi-Fan Jiang Ying-Ye Ou Dao-Feng Chen |
| author_sort | Yi-Wen Jiang |
| collection | DOAJ |
| description | Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs. The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium have anticomplementary activity and immunomodulatory functions on macrophages. To study its potential benefit on SLE, we examined effects of BPs on MRL-lpr mice, which have similar disease features to human SLE. MRL-lpr mice were treated orally with BPs 15, 30, or 60 mg kg−1 day−1 for 12 weeks and their SLE characteristics were evaluated. The results revealed that BPs elongated life span, improved kidney function, delayed lymphadenopathy, and reduced autoantibodies. It seemed to be mediated by inhibition of complement and macrophages activation and suppression of interferon-γ (IFN-γ) and interleukin-6 (IL-6) gene expression in the kidney. These results implicate that BPs may be an immunomodulator for the treatment of autoimmune diseases like SLE. |
| format | Article |
| id | doaj-art-d86d518b8e044a2fa0da7a0f93bcc780 |
| institution | DOAJ |
| issn | 1740-2522 1740-2530 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical and Developmental Immunology |
| spelling | doaj-art-d86d518b8e044a2fa0da7a0f93bcc7802025-08-20T03:23:51ZengWileyClinical and Developmental Immunology1740-25221740-25302012-01-01201210.1155/2012/842928842928Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr MiceYi-Wen Jiang0Hong Li1Yun-Yi Zhang2Wen Li3Yi-Fan Jiang4Ying-Ye Ou5Dao-Feng Chen6Department of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacology, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaDepartment of Pharmacognosy, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, ChinaSystemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease leading to inflammatory tissue damage in multiple organs. The crude polysaccharides (BPs) isolated from the roots of Bupleurum smithii var. parvifolium have anticomplementary activity and immunomodulatory functions on macrophages. To study its potential benefit on SLE, we examined effects of BPs on MRL-lpr mice, which have similar disease features to human SLE. MRL-lpr mice were treated orally with BPs 15, 30, or 60 mg kg−1 day−1 for 12 weeks and their SLE characteristics were evaluated. The results revealed that BPs elongated life span, improved kidney function, delayed lymphadenopathy, and reduced autoantibodies. It seemed to be mediated by inhibition of complement and macrophages activation and suppression of interferon-γ (IFN-γ) and interleukin-6 (IL-6) gene expression in the kidney. These results implicate that BPs may be an immunomodulator for the treatment of autoimmune diseases like SLE.http://dx.doi.org/10.1155/2012/842928 |
| spellingShingle | Yi-Wen Jiang Hong Li Yun-Yi Zhang Wen Li Yi-Fan Jiang Ying-Ye Ou Dao-Feng Chen Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice Clinical and Developmental Immunology |
| title | Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice |
| title_full | Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice |
| title_fullStr | Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice |
| title_full_unstemmed | Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice |
| title_short | Beneficial Effect of Bupleurum Polysaccharides on Autoimmune-Prone MRL-lpr Mice |
| title_sort | beneficial effect of bupleurum polysaccharides on autoimmune prone mrl lpr mice |
| url | http://dx.doi.org/10.1155/2012/842928 |
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