The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme

An acidic shift in the pH profile of <i>Clonostachys rosea</i> zearalenone hydrolase (ZHD), the most effective and well-studied zearalenone-specific lactone hydrolase, is required to extend the range of applications for the enzyme as a decontamination agent in the feed and food productio...

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Main Authors: Anna Dotsenko, Igor Sinelnikov, Ivan Zorov, Yury Denisenko, Aleksandra Rozhkova, Larisa Shcherbakova
Format: Article
Language:English
Published: MDPI AG 2024-12-01
Series:Toxins
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Online Access:https://www.mdpi.com/2072-6651/16/12/540
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author Anna Dotsenko
Igor Sinelnikov
Ivan Zorov
Yury Denisenko
Aleksandra Rozhkova
Larisa Shcherbakova
author_facet Anna Dotsenko
Igor Sinelnikov
Ivan Zorov
Yury Denisenko
Aleksandra Rozhkova
Larisa Shcherbakova
author_sort Anna Dotsenko
collection DOAJ
description An acidic shift in the pH profile of <i>Clonostachys rosea</i> zearalenone hydrolase (ZHD), the most effective and well-studied zearalenone-specific lactone hydrolase, is required to extend the range of applications for the enzyme as a decontamination agent in the feed and food production industries. Amino acid substitutions were engineered in the active center of the enzyme to decrease the pKa values of the catalytic residues E126 and H242. The T216K substitution provided a shift in the pH optimum by one unit to the acidic region, accompanied by a notable expansion in the pH profile under acidic conditions. The engineered enzyme demonstrated enhanced activity within the pH range of 3–5 and improved the activity within the pH ranging from 6 to 10. The D31N and D31A substitutions also resulted in a two-unit shift in the pH optimum towards acidic conditions, although this was accompanied by a significant reduction in the enzyme activity. The D31S substitution resulted in a shift in the pH profile towards the alkaline region. The alterations in the enzyme properties observed following the T216K substitution were consistent with the conditions required for the ZHD application as decontamination enzymes at acidic pH values (from 3.0 to 6.0).
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spelling doaj-art-d867a23b471349b49103e2bb6a35d1e32025-08-20T02:01:29ZengMDPI AGToxins2072-66512024-12-01161254010.3390/toxins16120540The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the EnzymeAnna Dotsenko0Igor Sinelnikov1Ivan Zorov2Yury Denisenko3Aleksandra Rozhkova4Larisa Shcherbakova5Federal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (RAS), 119071 Moscow, RussiaFederal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (RAS), 119071 Moscow, RussiaDepartment of Chemistry, Lomonosov Moscow State University, 119991 Moscow, RussiaFederal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (RAS), 119071 Moscow, RussiaFederal Research Centre “Fundamentals of Biotechnology” of the Russian Academy of Sciences (RAS), 119071 Moscow, RussiaAll-Russian Research Institute of Phytopathology of RAS, Bolshie Vyazemy, 143050 Moscow, RussiaAn acidic shift in the pH profile of <i>Clonostachys rosea</i> zearalenone hydrolase (ZHD), the most effective and well-studied zearalenone-specific lactone hydrolase, is required to extend the range of applications for the enzyme as a decontamination agent in the feed and food production industries. Amino acid substitutions were engineered in the active center of the enzyme to decrease the pKa values of the catalytic residues E126 and H242. The T216K substitution provided a shift in the pH optimum by one unit to the acidic region, accompanied by a notable expansion in the pH profile under acidic conditions. The engineered enzyme demonstrated enhanced activity within the pH range of 3–5 and improved the activity within the pH ranging from 6 to 10. The D31N and D31A substitutions also resulted in a two-unit shift in the pH optimum towards acidic conditions, although this was accompanied by a significant reduction in the enzyme activity. The D31S substitution resulted in a shift in the pH profile towards the alkaline region. The alterations in the enzyme properties observed following the T216K substitution were consistent with the conditions required for the ZHD application as decontamination enzymes at acidic pH values (from 3.0 to 6.0).https://www.mdpi.com/2072-6651/16/12/540zearalenoneenzymatic degradationlactonohydrolaserecombinant proteinsprotein engineeringpH profile
spellingShingle Anna Dotsenko
Igor Sinelnikov
Ivan Zorov
Yury Denisenko
Aleksandra Rozhkova
Larisa Shcherbakova
The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
Toxins
zearalenone
enzymatic degradation
lactonohydrolase
recombinant proteins
protein engineering
pH profile
title The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
title_full The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
title_fullStr The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
title_full_unstemmed The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
title_short The Protein Engineering of Zearalenone Hydrolase Results in a Shift in the pH Optimum of the Relative Activity of the Enzyme
title_sort protein engineering of zearalenone hydrolase results in a shift in the ph optimum of the relative activity of the enzyme
topic zearalenone
enzymatic degradation
lactonohydrolase
recombinant proteins
protein engineering
pH profile
url https://www.mdpi.com/2072-6651/16/12/540
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