TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES
Objective: in paper direct results of investigation the products of tumor makers – CEA (carcino-embryonic antigen), CYFRA 21-1 and SCC and heat shock proteins hsp27, hsp70, hsp90. reflacting the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis.Materials and methods. T...
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2017-06-01
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| Series: | Опухоли головы и шеи |
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| Online Access: | https://ogsh.abvpress.ru/jour/article/view/269 |
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| author | I. I. Nazmudinov M. Z. Saidov |
| author_facet | I. I. Nazmudinov M. Z. Saidov |
| author_sort | I. I. Nazmudinov |
| collection | DOAJ |
| description | Objective: in paper direct results of investigation the products of tumor makers – CEA (carcino-embryonic antigen), CYFRA 21-1 and SCC and heat shock proteins hsp27, hsp70, hsp90. reflacting the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis.Materials and methods. There were investigated 36 patients with chronic hyperplastic laryngitis. It was investigated the production of CEA (carcino-embryonic antigen), CYFRA 21-1, SCC and heat shock proteins hsp27, hsp70 in immune-enzyme method. The variation of serum concentration oncomarkers was investigated in dependent on the maximum production of heat shock proteins reflactihg the value of cell stress in chronic hyperplastic laryngitis. Statistics analysis was convey in programs Statistica (version 6,0) and “Biostat 4.03”.Results. It was shown more prognostic informative in chronic hyperplastic laryngitis the level of CEA, CYFRA 21-1 and SCC on the background of maximum production of heat shock proteins hsp27, hsp70, hsp90. The serum level of CEA was higher in comparison with control. On the maximum of production hsp27, hsp70, hsp90 the concentration of CEA was 2–3 ng/ml, Cyfra 21-1 – 0–1,2 ng/ml and SCC 1–2 ng/ml. Conclusions. Variation of serum oncomarkers level of CEA – 2–3 ng/ml, CYFRA 21-1 – 0–1,2 ng/ml and SCC – 1–2 ng/ml are the prognostic value in the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis. This results is important in clinical practice. |
| format | Article |
| id | doaj-art-d85b56c3406e4d4fa824de421c3e6681 |
| institution | Kabale University |
| issn | 2222-1468 2411-4634 |
| language | Russian |
| publishDate | 2017-06-01 |
| publisher | ABV-press |
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| series | Опухоли головы и шеи |
| spelling | doaj-art-d85b56c3406e4d4fa824de421c3e66812025-08-20T03:37:43ZrusABV-pressОпухоли головы и шеи2222-14682411-46342017-06-0172819110.17650/2222-1468-2017-7-2-81-91250TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTESI. I. Nazmudinov0M. Z. Saidov1Research and Clinical Center of Otorhinolaryngology, Russian Federal Medico-Biological AgencyDagestan state medical University, Ministry of Health of RussiaObjective: in paper direct results of investigation the products of tumor makers – CEA (carcino-embryonic antigen), CYFRA 21-1 and SCC and heat shock proteins hsp27, hsp70, hsp90. reflacting the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis.Materials and methods. There were investigated 36 patients with chronic hyperplastic laryngitis. It was investigated the production of CEA (carcino-embryonic antigen), CYFRA 21-1, SCC and heat shock proteins hsp27, hsp70 in immune-enzyme method. The variation of serum concentration oncomarkers was investigated in dependent on the maximum production of heat shock proteins reflactihg the value of cell stress in chronic hyperplastic laryngitis. Statistics analysis was convey in programs Statistica (version 6,0) and “Biostat 4.03”.Results. It was shown more prognostic informative in chronic hyperplastic laryngitis the level of CEA, CYFRA 21-1 and SCC on the background of maximum production of heat shock proteins hsp27, hsp70, hsp90. The serum level of CEA was higher in comparison with control. On the maximum of production hsp27, hsp70, hsp90 the concentration of CEA was 2–3 ng/ml, Cyfra 21-1 – 0–1,2 ng/ml and SCC 1–2 ng/ml. Conclusions. Variation of serum oncomarkers level of CEA – 2–3 ng/ml, CYFRA 21-1 – 0–1,2 ng/ml and SCC – 1–2 ng/ml are the prognostic value in the possibility of malignization epithelial cells in chronic hyperpiastic laryngitis. This results is important in clinical practice.https://ogsh.abvpress.ru/jour/article/view/269chronic hyperpiastic laryngitistumor makerscarcino-embryonic antigencyfra 21-1squamous cell carcinomaheat shock proteinsmalignisation |
| spellingShingle | I. I. Nazmudinov M. Z. Saidov TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES Опухоли головы и шеи chronic hyperpiastic laryngitis tumor makers carcino-embryonic antigen cyfra 21-1 squamous cell carcinoma heat shock proteins malignisation |
| title | TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES |
| title_full | TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES |
| title_fullStr | TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES |
| title_full_unstemmed | TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES |
| title_short | TUMOR MARKERS AND HEAT SHOCK PROTEINS OF CHRONIC HYPERPIASTIC LARYNGITIS AS A LIKELY PREDICTOR OF MALIGNISATION IN LARYNX EPITHELIOCYTES |
| title_sort | tumor markers and heat shock proteins of chronic hyperpiastic laryngitis as a likely predictor of malignisation in larynx epitheliocytes |
| topic | chronic hyperpiastic laryngitis tumor makers carcino-embryonic antigen cyfra 21-1 squamous cell carcinoma heat shock proteins malignisation |
| url | https://ogsh.abvpress.ru/jour/article/view/269 |
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