The Role of Epigenetic Changes in The Development of Diabetes Mellitus
Diabetes mellitus (DM) is one of the most abundant diseases in the 21st century and believed as result of interaction between genes and environment exposure. There is a hypotesis of epigenetic mechanisms, using molecular basis to explain about the mechanism of DM. Because of the enviromental exposur...
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| Format: | Article |
| Language: | English |
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Interna Publishing
2019-05-01
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| Series: | Acta Medica Indonesiana |
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| Online Access: | https://www.actamedindones.org/index.php/ijim/article/view/572 |
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| author | Wardhana Wardhana Djoko Wahono Soeatmadji |
| author_facet | Wardhana Wardhana Djoko Wahono Soeatmadji |
| author_sort | Wardhana Wardhana |
| collection | DOAJ |
| description | Diabetes mellitus (DM) is one of the most abundant diseases in the 21st century and believed as result of interaction between genes and environment exposure. There is a hypotesis of epigenetic mechanisms, using molecular basis to explain about the mechanism of DM. Because of the enviromental exposure including nutrition status and hyperglycemia state, the risk of DM has started since pre-conception, last until adulthood and will be inhireted trans-generational . Mainly, there are 3 epigenetic mechanisms that have role in DM. Epigenetic mechanisms are also have role in the metabolic memory that the DM complications may still developed although the blood glucose level is already normal. The restriction of calory intake may help delaying the development and onset of degerative diseases including DM by stabilizing genome through epigenetic mechanisms.
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| format | Article |
| id | doaj-art-d85af52b54fb4b70aebb48945cac72e8 |
| institution | Kabale University |
| issn | 0125-9326 2338-2732 |
| language | English |
| publishDate | 2019-05-01 |
| publisher | Interna Publishing |
| record_format | Article |
| series | Acta Medica Indonesiana |
| spelling | doaj-art-d85af52b54fb4b70aebb48945cac72e82025-08-20T03:25:52ZengInterna PublishingActa Medica Indonesiana0125-93262338-27322019-05-01511The Role of Epigenetic Changes in The Development of Diabetes MellitusWardhana Wardhana0Djoko Wahono Soeatmadji1Division of Endocrinology-Metabolic, Department of Internal Medicine, Brawijaya University-dr.Saiful Anwar Teaching Hospital. Malang. Jawa Timur. Indonesia.Endocrinilogy, Metabolic, and Diabetes Division, Department of Internal Medicine, Brawijaya University School of Medicine-dr.Saiful Anwar Teaching Hospital, Malang, East Jawa,IndonesiaDiabetes mellitus (DM) is one of the most abundant diseases in the 21st century and believed as result of interaction between genes and environment exposure. There is a hypotesis of epigenetic mechanisms, using molecular basis to explain about the mechanism of DM. Because of the enviromental exposure including nutrition status and hyperglycemia state, the risk of DM has started since pre-conception, last until adulthood and will be inhireted trans-generational . Mainly, there are 3 epigenetic mechanisms that have role in DM. Epigenetic mechanisms are also have role in the metabolic memory that the DM complications may still developed although the blood glucose level is already normal. The restriction of calory intake may help delaying the development and onset of degerative diseases including DM by stabilizing genome through epigenetic mechanisms. https://www.actamedindones.org/index.php/ijim/article/view/572Diabetesepigenetic mechanismsmetabolic memory |
| spellingShingle | Wardhana Wardhana Djoko Wahono Soeatmadji The Role of Epigenetic Changes in The Development of Diabetes Mellitus Acta Medica Indonesiana Diabetes epigenetic mechanisms metabolic memory |
| title | The Role of Epigenetic Changes in The Development of Diabetes Mellitus |
| title_full | The Role of Epigenetic Changes in The Development of Diabetes Mellitus |
| title_fullStr | The Role of Epigenetic Changes in The Development of Diabetes Mellitus |
| title_full_unstemmed | The Role of Epigenetic Changes in The Development of Diabetes Mellitus |
| title_short | The Role of Epigenetic Changes in The Development of Diabetes Mellitus |
| title_sort | role of epigenetic changes in the development of diabetes mellitus |
| topic | Diabetes epigenetic mechanisms metabolic memory |
| url | https://www.actamedindones.org/index.php/ijim/article/view/572 |
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