P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES
Hippo signaling pathway has been reported that it participates in many events such as cell division, proliferation, differentiation, and programmed cell death. YAP (Yes-Associated Protein) is one of the key components of this pathway1. It has been reported that early life stress causes oxidative st...
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| Language: | English |
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PAGEPress Publications
2025-08-01
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| Series: | European Journal of Histochemistry |
| Online Access: | https://www.ejh.it/ejh/article/view/4355 |
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Hippo signaling pathway has been reported that it participates in many events such as cell division, proliferation, differentiation, and programmed cell death. YAP (Yes-Associated Protein) is one of the key components of this pathway1. It has been reported that early life stress causes oxidative stress in the mouse ovary which can affect follicle development2. However, the molecular mechanisms underlying these problems caused by early life stress have not yet been elucidated. 180-min maternal deprivation and isolation model was applied to the experimental group every day between the 1st and 14th postnatal day3. In total of 6 newborn Wistar albino female rats were used as control (n=3) and experimental (n=3) groups. Tail blood was collected to determine the serum corticosterone level before and after stress conditions on 14th postnatal day whether early life stress had developed. The groups were sacrificed on the 55th postnatal day. The YAP expression level was evaluated for immunohistochemical analyses. When compared to the control group, the serum corticosterone levels were high (p<0.05) and YAP expressions increased in granulosa cells and corpus luteum of the experimental group (p<0.05). This study suggests that stress created in the early period may cause various errors as the ovaries enter the adulthood period. It is also thought that the Hippo pathway plays an active role in this process.
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| format | Article |
| id | doaj-art-d858fb84a7b341fa96f6b665d276c6e7 |
| institution | Kabale University |
| issn | 1121-760X 2038-8306 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | PAGEPress Publications |
| record_format | Article |
| series | European Journal of Histochemistry |
| spelling | doaj-art-d858fb84a7b341fa96f6b665d276c6e72025-08-23T11:18:59ZengPAGEPress PublicationsEuropean Journal of Histochemistry1121-760X2038-83062025-08-0169s210.4081/ejh.2025.4355P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES Hippo signaling pathway has been reported that it participates in many events such as cell division, proliferation, differentiation, and programmed cell death. YAP (Yes-Associated Protein) is one of the key components of this pathway1. It has been reported that early life stress causes oxidative stress in the mouse ovary which can affect follicle development2. However, the molecular mechanisms underlying these problems caused by early life stress have not yet been elucidated. 180-min maternal deprivation and isolation model was applied to the experimental group every day between the 1st and 14th postnatal day3. In total of 6 newborn Wistar albino female rats were used as control (n=3) and experimental (n=3) groups. Tail blood was collected to determine the serum corticosterone level before and after stress conditions on 14th postnatal day whether early life stress had developed. The groups were sacrificed on the 55th postnatal day. The YAP expression level was evaluated for immunohistochemical analyses. When compared to the control group, the serum corticosterone levels were high (p<0.05) and YAP expressions increased in granulosa cells and corpus luteum of the experimental group (p<0.05). This study suggests that stress created in the early period may cause various errors as the ovaries enter the adulthood period. It is also thought that the Hippo pathway plays an active role in this process. https://www.ejh.it/ejh/article/view/4355 |
| spellingShingle | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES European Journal of Histochemistry |
| title | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES |
| title_full | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES |
| title_fullStr | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES |
| title_full_unstemmed | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES |
| title_short | P35 | EARLY LIFE STRESS CAN CAUSE CHANGES IN THE HIPPO SIGNALING PATHWAY IN RAT OVARIES |
| title_sort | p35 early life stress can cause changes in the hippo signaling pathway in rat ovaries |
| url | https://www.ejh.it/ejh/article/view/4355 |