Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand
A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental an...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | E-Journal of Chemistry |
| Online Access: | http://dx.doi.org/10.1155/2012/291850 |
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| author | B. Anupama M. Padmaja C. Gyana Kumari |
| author_facet | B. Anupama M. Padmaja C. Gyana Kumari |
| author_sort | B. Anupama |
| collection | DOAJ |
| description | A new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS, 1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2 type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods. |
| format | Article |
| id | doaj-art-d8508447f119402cadd40714ebd1fd5d |
| institution | Kabale University |
| issn | 0973-4945 2090-9810 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | E-Journal of Chemistry |
| spelling | doaj-art-d8508447f119402cadd40714ebd1fd5d2025-02-03T07:25:49ZengWileyE-Journal of Chemistry0973-49452090-98102012-01-019138940010.1155/2012/291850Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base LigandB. Anupama0M. Padmaja1C. Gyana Kumari2Departrment of Chemistry, Osmania University, Hyderabad-500007, IndiaDepartrment of Chemistry, Osmania University, Hyderabad-500007, IndiaDepartrment of Chemistry, Osmania University, Hyderabad-500007, IndiaA new series of transition metal complexes of Cu(II),Ni(II),Co(II), Zn(II) and VO(IV) have been synthesized from the Schiff base ligand (L) derived from 4-amino antipyrine and 5- bromo salicylaldehyde. The structural features of Schiff base and metal complexes were determined from their elemental analyses, thermogravimetric studies, magneticsusceptibility, molar conductivity, ESI-Mass, IR, UV-VIS, 1H NMR and ESR spectral studies. The data show that the complexes have composition of ML2 type. The UV-VIS, magnetic susceptibility and ESR spectral data suggest an octahedral geometry around the central metal ion. Biological screening of the complexes reveals that the Schiff base transition metal complexes show significant activity against microorganisms. Binding of Co(II) complex with calf thymus DNA (CT DNA) was studied by spectral methods.http://dx.doi.org/10.1155/2012/291850 |
| spellingShingle | B. Anupama M. Padmaja C. Gyana Kumari Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand E-Journal of Chemistry |
| title | Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand |
| title_full | Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand |
| title_fullStr | Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand |
| title_full_unstemmed | Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand |
| title_short | Synthesis, Characterization, Biological Activity and DNA Binding Studies of Metal Complexes with 4-Aminoantipyrine Schiff Base Ligand |
| title_sort | synthesis characterization biological activity and dna binding studies of metal complexes with 4 aminoantipyrine schiff base ligand |
| url | http://dx.doi.org/10.1155/2012/291850 |
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