Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

Diverse evolutionary trajectories of Klebsiella pneumoniae carbapenemase: unraveling the impact of amino acid substitutions on β-lactam susceptibility and the role of avibactam in driving resistance

ABSTRACT Klebsiella pneumoniae carbapenemases (KPCs) have evolved into over 245 distinct variants, with over one-third of variants exhibiting reduced susceptibility to ceftazidime-avibactam, while the underlying selection mechanisms remain elusive. To better elucidate these resistant phenotypes, we...

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Bibliographic Details
Main Authors: Jie Wei, Jinyu Huang, Chunhong Zou, Shimei Shen, Barry N. Kreiswirth, Ailong Huang, Shifeng Huang, Liang Chen, Deqiang Wang, Siqiang Niu
Format: Article
Language:English
Published: American Society for Microbiology 2025-04-01
Series:mSystems
Subjects:
KPC (Klebsiella pneumoniae carbapenemase)
phylogenetic reconstruction
ceftazidime-avibactam
evolution
resistance
Online Access:https://journals.asm.org/doi/10.1128/msystems.00184-25
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