Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population
Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of sur...
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| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | Case Reports in Transplantation |
| Online Access: | http://dx.doi.org/10.1155/2021/8667589 |
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| author | Taryn A. Eubank Constance M. Mobley Mozhgon Moaddab Mark J. Hobeika Melissa O’Neal William L. Musick Joshua M. Knight Joseph S. Galati Sudha Kodali Akshay Shetty David W. Victor Ashish Saharia R. Mark Ghobrial Kevin A. Grimes |
| author_facet | Taryn A. Eubank Constance M. Mobley Mozhgon Moaddab Mark J. Hobeika Melissa O’Neal William L. Musick Joshua M. Knight Joseph S. Galati Sudha Kodali Akshay Shetty David W. Victor Ashish Saharia R. Mark Ghobrial Kevin A. Grimes |
| author_sort | Taryn A. Eubank |
| collection | DOAJ |
| description | Mucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment. |
| format | Article |
| id | doaj-art-d84685098aae484d848e354f7fdad4e9 |
| institution | OA Journals |
| issn | 2090-6951 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Transplantation |
| spelling | doaj-art-d84685098aae484d848e354f7fdad4e92025-08-20T02:20:58ZengWileyCase Reports in Transplantation2090-69512021-01-01202110.1155/2021/8667589Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant PopulationTaryn A. Eubank0Constance M. Mobley1Mozhgon Moaddab2Mark J. Hobeika3Melissa O’Neal4William L. Musick5Joshua M. Knight6Joseph S. Galati7Sudha Kodali8Akshay Shetty9David W. Victor10Ashish Saharia11R. Mark Ghobrial12Kevin A. Grimes13Department of PharmacyDepartment of SurgeryDepartment of PharmacyDepartment of SurgeryDepartment of PharmacyDepartment of PharmacyDepartment of PharmacyJC Walter Jr Transplant CenterJC Walter Jr Transplant CenterJC Walter Jr Transplant CenterJC Walter Jr Transplant CenterDepartment of SurgeryDepartment of SurgerySherrie and Alan Conover Center for Liver Disease & TransplantationMucormycosis is caused by ubiquitous fungi and encompasses a variety of different opportunistic syndromes in humans that disproportionately affect immunocompromised patients. Mortality has been documented to range between 50 and 100%; however, location of infection greatly dictates likelihood of survival. Treatment of mucormycosis involves aggressive surgical intervention and combination therapy of antifungal agents. In solid organ transplant recipients, immunosuppressive agents used to prevent rejection of the transplanted organ pose additional obstacles in the treatment of invasive fungal infections. We report on 3 high models for end-stage liver disease (MELD-Na) score orthotopic liver transplant (OLT) recipients who all were diagnosed with Rhizopus spp. infections with positive, 1-year outcomes after aggressive, individualized treatment.http://dx.doi.org/10.1155/2021/8667589 |
| spellingShingle | Taryn A. Eubank Constance M. Mobley Mozhgon Moaddab Mark J. Hobeika Melissa O’Neal William L. Musick Joshua M. Knight Joseph S. Galati Sudha Kodali Akshay Shetty David W. Victor Ashish Saharia R. Mark Ghobrial Kevin A. Grimes Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population Case Reports in Transplantation |
| title | Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population |
| title_full | Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population |
| title_fullStr | Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population |
| title_full_unstemmed | Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population |
| title_short | Successful Treatment of Invasive Mucormycosis in Orthotopic Liver Transplant Population |
| title_sort | successful treatment of invasive mucormycosis in orthotopic liver transplant population |
| url | http://dx.doi.org/10.1155/2021/8667589 |
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