Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations
Yining Lu,1,2,* Jiaoran Liu,3,* Wei Chen,1 Pan Hu,4 Yan Pei,2 Yiming Gao,2 Hairong Lu,5 Ling Wang,1,2 Yingze Zhang1 1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Ortho...
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Dove Medical Press
2025-06-01
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| Series: | Journal of Inflammation Research |
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| Online Access: | https://www.dovepress.com/novel-proteomic-insights-into-hip-fractures-in-the-elderly-unraveling--peer-reviewed-fulltext-article-JIR |
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| author | Lu Y Liu J Chen W Hu P Pei Y Gao Y Lu H Wang L Zhang Y |
| author_facet | Lu Y Liu J Chen W Hu P Pei Y Gao Y Lu H Wang L Zhang Y |
| author_sort | Lu Y |
| collection | DOAJ |
| description | Yining Lu,1,2,* Jiaoran Liu,3,* Wei Chen,1 Pan Hu,4 Yan Pei,2 Yiming Gao,2 Hairong Lu,5 Ling Wang,1,2 Yingze Zhang1 1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Ultrasound Diagnosis, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Trauma Medicine Center, Peking University People’s hospital, Beijing, China; National Center for Trauma Medicine, Beijing, People’s Republic of China; 5Department of Geriatric orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingze Zhang, Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email yzzhang@hebmu.edu.cn Ling Wang, Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email wangling2016uw@126.com; wangling2021@hebmu.edu.cnBackground: Hip fractures in the elderly triggers a severe inflammatory immune response.Methods: Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.Results: Dynamic trends in inflammatory proteins after surgery were assessed. Correlation analyses showed significant associations between inflammation-related proteins and clinical parameters. A prognostic risk score model was developed: on day 1, CCL19, FGF-19 and MCP-2 were significant; on day 3, TGF-α, FGF-5, CCL19, IL-22RA1 and IL-12B were included; and on day 7, IL-2RB, CCL19 and 4E-BP1 were significant. High-risk patients had a significantly lower rate of recovery compared with low-risk patients.Conclusion: In this study, we have highlighted the complex inflammatory response during fracture healing and emphasised the importance of long-term monitoring of protein dynamics.Keywords: geriatric hip fracture, immune, inflammation, prognosis, Olink |
| format | Article |
| id | doaj-art-d8450f243d874456911ea9be635aa0f3 |
| institution | Kabale University |
| issn | 1178-7031 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj-art-d8450f243d874456911ea9be635aa0f32025-08-20T03:26:57ZengDove Medical PressJournal of Inflammation Research1178-70312025-06-01Volume 18Issue 177037716103810Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical CorrelationsLu Y0Liu JChen W1Hu PPei Y2Gao YLu HWang L3Zhang Y4Department of Orthopedic SurgeryDepartment of orthopedic surgeryHebei Medical Universityhebei medical universityDepartment of OrthopaedicsYining Lu,1,2,* Jiaoran Liu,3,* Wei Chen,1 Pan Hu,4 Yan Pei,2 Yiming Gao,2 Hairong Lu,5 Ling Wang,1,2 Yingze Zhang1 1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Ultrasound Diagnosis, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Trauma Medicine Center, Peking University People’s hospital, Beijing, China; National Center for Trauma Medicine, Beijing, People’s Republic of China; 5Department of Geriatric orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingze Zhang, Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email yzzhang@hebmu.edu.cn Ling Wang, Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email wangling2016uw@126.com; wangling2021@hebmu.edu.cnBackground: Hip fractures in the elderly triggers a severe inflammatory immune response.Methods: Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.Results: Dynamic trends in inflammatory proteins after surgery were assessed. Correlation analyses showed significant associations between inflammation-related proteins and clinical parameters. A prognostic risk score model was developed: on day 1, CCL19, FGF-19 and MCP-2 were significant; on day 3, TGF-α, FGF-5, CCL19, IL-22RA1 and IL-12B were included; and on day 7, IL-2RB, CCL19 and 4E-BP1 were significant. High-risk patients had a significantly lower rate of recovery compared with low-risk patients.Conclusion: In this study, we have highlighted the complex inflammatory response during fracture healing and emphasised the importance of long-term monitoring of protein dynamics.Keywords: geriatric hip fracture, immune, inflammation, prognosis, Olinkhttps://www.dovepress.com/novel-proteomic-insights-into-hip-fractures-in-the-elderly-unraveling--peer-reviewed-fulltext-article-JIRGeriatric Hip FractureImmuneInflammationPrognosisOlink |
| spellingShingle | Lu Y Liu J Chen W Hu P Pei Y Gao Y Lu H Wang L Zhang Y Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations Journal of Inflammation Research Geriatric Hip Fracture Immune Inflammation Prognosis Olink |
| title | Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations |
| title_full | Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations |
| title_fullStr | Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations |
| title_full_unstemmed | Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations |
| title_short | Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations |
| title_sort | novel proteomic insights into hip fractures in the elderly unraveling immunologic biomarkers temporal expression patterns and clinical correlations |
| topic | Geriatric Hip Fracture Immune Inflammation Prognosis Olink |
| url | https://www.dovepress.com/novel-proteomic-insights-into-hip-fractures-in-the-elderly-unraveling--peer-reviewed-fulltext-article-JIR |
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