Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review
Introduction Haematological cancers are common in the UK, with a variety of morphologies. Stem cell transplants and chimeric antigen receptor (CAR) T-cell therapies provide significant options for hard to treat haematological cancers, although with difficult to predict outcomes. Research into the de...
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| Format: | Article |
| Language: | English |
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BMJ Publishing Group
2025-05-01
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| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/15/5/e099354.full |
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| author | Krishnarajah Nirantharakumar Alastair K Denniston Joht Singh Chandan Nicola Adderley David Burns Samuel Cusworth Zareen Deplano |
| author_facet | Krishnarajah Nirantharakumar Alastair K Denniston Joht Singh Chandan Nicola Adderley David Burns Samuel Cusworth Zareen Deplano |
| author_sort | Krishnarajah Nirantharakumar |
| collection | DOAJ |
| description | Introduction Haematological cancers are common in the UK, with a variety of morphologies. Stem cell transplants and chimeric antigen receptor (CAR) T-cell therapies provide significant options for hard to treat haematological cancers, although with difficult to predict outcomes. Research into the determinates of treatment efficacy, and access to treatments, is key to ensuring equal benefit across patients and patient safety. With this, there are concerns about the small representation of minority groups in related research. We aim to report on the current knowledge to guide future research.Methods and analysis A variety of databases will be searched for literature on UK minority ethnic populations receiving haematopoietic stem cell transplant or CAR T-cell therapy. Searches will be restricted to the year 2011 or later. Many outcomes will be analysed, covering the patient care pathway for those of the target population, although with a focus on follow-up after therapy. Plans have been made to conduct narrative synthesis, with meta-analysis where applicable.Ethics and dissemination Ethical approval is not required for this study. Outputs will be published in an appropriate journal and discussed with the wider National Institute for Health and Care Research Blood and Transplant Research Unit in Precision Transplant and Cellular Therapeutics (BTRU) group. Discussions will also be undertaken with the BTRU patient partners group. |
| format | Article |
| id | doaj-art-d843ea73a7a74bd380817ffdb2f41b2d |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-d843ea73a7a74bd380817ffdb2f41b2d2025-08-20T03:47:33ZengBMJ Publishing GroupBMJ Open2044-60552025-05-0115510.1136/bmjopen-2025-099354Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic reviewKrishnarajah Nirantharakumar0Alastair K Denniston1Joht Singh Chandan2Nicola Adderley3David Burns4Samuel Cusworth5Zareen Deplano62 Department of Applied Health Sciences, University of Birmingham, Birmingham, UK4 Ophthalmology Department, Queen Elizabeth Hospital Birmingham, Birmingham, UK2 Department of Applied Health Sciences, University of Birmingham, Birmingham, UK2 Department of Applied Health Sciences, University of Birmingham, Birmingham, UK9 University Hospitals Plymouth NHS Trust, Plymouth, UK1 NIHR, Blood and Transplant Research Unit (BTRU) in Precision Transplant and Cellular Therapeutics, University of Birmingham, Birmingham, England, UK2 Department of Applied Health Sciences, University of Birmingham, Birmingham, UKIntroduction Haematological cancers are common in the UK, with a variety of morphologies. Stem cell transplants and chimeric antigen receptor (CAR) T-cell therapies provide significant options for hard to treat haematological cancers, although with difficult to predict outcomes. Research into the determinates of treatment efficacy, and access to treatments, is key to ensuring equal benefit across patients and patient safety. With this, there are concerns about the small representation of minority groups in related research. We aim to report on the current knowledge to guide future research.Methods and analysis A variety of databases will be searched for literature on UK minority ethnic populations receiving haematopoietic stem cell transplant or CAR T-cell therapy. Searches will be restricted to the year 2011 or later. Many outcomes will be analysed, covering the patient care pathway for those of the target population, although with a focus on follow-up after therapy. Plans have been made to conduct narrative synthesis, with meta-analysis where applicable.Ethics and dissemination Ethical approval is not required for this study. Outputs will be published in an appropriate journal and discussed with the wider National Institute for Health and Care Research Blood and Transplant Research Unit in Precision Transplant and Cellular Therapeutics (BTRU) group. Discussions will also be undertaken with the BTRU patient partners group.https://bmjopen.bmj.com/content/15/5/e099354.full |
| spellingShingle | Krishnarajah Nirantharakumar Alastair K Denniston Joht Singh Chandan Nicola Adderley David Burns Samuel Cusworth Zareen Deplano Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review BMJ Open |
| title | Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review |
| title_full | Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review |
| title_fullStr | Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review |
| title_full_unstemmed | Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review |
| title_short | Protocol: what are the ethnic inequities in care outcomes related to haematological malignancies, treated with transplant/cellular therapies, in the UK? A systematic review |
| title_sort | protocol what are the ethnic inequities in care outcomes related to haematological malignancies treated with transplant cellular therapies in the uk a systematic review |
| url | https://bmjopen.bmj.com/content/15/5/e099354.full |
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