Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer
<b>Background/Objectives</b>: This study aimed to investigate the impact of preoperative weight loss on long-term postoperative survival and the significance of preoperative nutrition on perioperative weight change in patients with pancreatic cancer. <b>Methods</b>: Overall,...
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MDPI AG
2025-07-01
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| author | Mariko Tsukagoshi Kenichiro Araki Norio Kubo Takamichi Igarashi Shunsuke Kawai Kei Hagiwara Kouki Hoshino Takaomi Seki Takayuki Okuyama Ryosuke Fukushima Takahiro Shoda Ken Shirabe |
| author_facet | Mariko Tsukagoshi Kenichiro Araki Norio Kubo Takamichi Igarashi Shunsuke Kawai Kei Hagiwara Kouki Hoshino Takaomi Seki Takayuki Okuyama Ryosuke Fukushima Takahiro Shoda Ken Shirabe |
| author_sort | Mariko Tsukagoshi |
| collection | DOAJ |
| description | <b>Background/Objectives</b>: This study aimed to investigate the impact of preoperative weight loss on long-term postoperative survival and the significance of preoperative nutrition on perioperative weight change in patients with pancreatic cancer. <b>Methods</b>: Overall, 125 patients who underwent radical resection for invasive pancreatic ductal carcinoma were retrospectively analyzed. The preoperative weight loss rate (pre-%WL) from the initial visit to immediately before surgery was calculated. Patients were classified by pre-%WL into the weight-loss (≥6% loss) and weight-maintenance (<6% loss) groups. The association of pre-%WL with postoperative outcomes and long-term survival was assessed. We evaluated preoperative nutrition’s effect on perioperative weight change. <b>Results</b>: The study cohort included 91 (73%) and 34 (27%) patients with weight maintenance and weight loss, respectively. Specifically, the weight-loss group had a longer operative time (<i>p</i> = 0.025) and greater blood loss (<i>p</i> = 0.018) than the weight-maintenance group. Patients with weight loss had significantly poorer recurrence-free survival (RFS; 8.7 vs. 17.8 months, <i>p</i> = 0.004) and overall survival (OS; 18.1 vs. 45.2 months, <i>p</i> = 0.002) than those with weight maintenance. Multivariate analysis revealed weight loss as an independent prognostic indicator of poor RFS (hazard ratio = 2.07; <i>p</i> = 0.003) and OS (hazard ratio = 2.55; <i>p</i> = 0.0008). The presence or absence of preoperative nutritional therapy was not correlated with the pre-%WL but was associated with postoperative (by the time of discharge) weight loss rate (median weight change rate: −2.9% vs. −5.6%, <i>p</i> = 0.001). <b>Conclusions</b>: Preoperative weight loss ≥ 6% was associated with poor RFS and OS in patients with pancreatic cancer. Although preoperative nutritional therapy did not suppress preoperative weight loss, it suppressed postoperative weight loss. |
| format | Article |
| id | doaj-art-d840650140b240c1a859f7c2eabb49c8 |
| institution | Kabale University |
| issn | 2227-9059 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
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| series | Biomedicines |
| spelling | doaj-art-d840650140b240c1a859f7c2eabb49c82025-08-20T03:35:58ZengMDPI AGBiomedicines2227-90592025-07-01137170310.3390/biomedicines13071703Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic CancerMariko Tsukagoshi0Kenichiro Araki1Norio Kubo2Takamichi Igarashi3Shunsuke Kawai4Kei Hagiwara5Kouki Hoshino6Takaomi Seki7Takayuki Okuyama8Ryosuke Fukushima9Takahiro Shoda10Ken Shirabe11Division of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, JapanDivision of Hepatobiliary and Pancreatic Surgery, Department of General Surgical Science, Gunma University Graduate School of Medicine, 3-39-22 Showa-machi, Maebashi 371-8511, Gunma, Japan<b>Background/Objectives</b>: This study aimed to investigate the impact of preoperative weight loss on long-term postoperative survival and the significance of preoperative nutrition on perioperative weight change in patients with pancreatic cancer. <b>Methods</b>: Overall, 125 patients who underwent radical resection for invasive pancreatic ductal carcinoma were retrospectively analyzed. The preoperative weight loss rate (pre-%WL) from the initial visit to immediately before surgery was calculated. Patients were classified by pre-%WL into the weight-loss (≥6% loss) and weight-maintenance (<6% loss) groups. The association of pre-%WL with postoperative outcomes and long-term survival was assessed. We evaluated preoperative nutrition’s effect on perioperative weight change. <b>Results</b>: The study cohort included 91 (73%) and 34 (27%) patients with weight maintenance and weight loss, respectively. Specifically, the weight-loss group had a longer operative time (<i>p</i> = 0.025) and greater blood loss (<i>p</i> = 0.018) than the weight-maintenance group. Patients with weight loss had significantly poorer recurrence-free survival (RFS; 8.7 vs. 17.8 months, <i>p</i> = 0.004) and overall survival (OS; 18.1 vs. 45.2 months, <i>p</i> = 0.002) than those with weight maintenance. Multivariate analysis revealed weight loss as an independent prognostic indicator of poor RFS (hazard ratio = 2.07; <i>p</i> = 0.003) and OS (hazard ratio = 2.55; <i>p</i> = 0.0008). The presence or absence of preoperative nutritional therapy was not correlated with the pre-%WL but was associated with postoperative (by the time of discharge) weight loss rate (median weight change rate: −2.9% vs. −5.6%, <i>p</i> = 0.001). <b>Conclusions</b>: Preoperative weight loss ≥ 6% was associated with poor RFS and OS in patients with pancreatic cancer. Although preoperative nutritional therapy did not suppress preoperative weight loss, it suppressed postoperative weight loss.https://www.mdpi.com/2227-9059/13/7/1703body weightnutritionoutcomepancreatic cancerprognosissurgery |
| spellingShingle | Mariko Tsukagoshi Kenichiro Araki Norio Kubo Takamichi Igarashi Shunsuke Kawai Kei Hagiwara Kouki Hoshino Takaomi Seki Takayuki Okuyama Ryosuke Fukushima Takahiro Shoda Ken Shirabe Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer Biomedicines body weight nutrition outcome pancreatic cancer prognosis surgery |
| title | Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer |
| title_full | Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer |
| title_fullStr | Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer |
| title_full_unstemmed | Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer |
| title_short | Impact of Preoperative Weight Loss on Prognosis in Patients with Pancreatic Cancer |
| title_sort | impact of preoperative weight loss on prognosis in patients with pancreatic cancer |
| topic | body weight nutrition outcome pancreatic cancer prognosis surgery |
| url | https://www.mdpi.com/2227-9059/13/7/1703 |
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