Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup
Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, o...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Case Reports in Surgery |
| Online Access: | http://dx.doi.org/10.1155/2013/107315 |
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| author | Ali S. Shirzadi Doniel G. Drazin Allison S. Strickland Serguei I. Bannykh J. Patrick Johnson |
| author_facet | Ali S. Shirzadi Doniel G. Drazin Allison S. Strickland Serguei I. Bannykh J. Patrick Johnson |
| author_sort | Ali S. Shirzadi |
| collection | DOAJ |
| description | Esthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient’s disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection. Despite aggressive multiple surgical resections, radiation, and chemotherapy, the tumor had significant progression and recurrence. The literature is reviewed, followed by a discussion of the natural progression of the disease and various reported interventions. Although a combination of surgery with chemotherapy and radiation therapy has been recommended, no definitive management has been established for ENB. Further research is needed to determine decisive treatment for metastatic ENB to the spine. |
| format | Article |
| id | doaj-art-d83f713fd524401782326824a34e3fc7 |
| institution | Kabale University |
| issn | 2090-6900 2090-6919 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Surgery |
| spelling | doaj-art-d83f713fd524401782326824a34e3fc72025-02-03T01:02:42ZengWileyCase Reports in Surgery2090-69002090-69192013-01-01201310.1155/2013/107315107315Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year FollowupAli S. Shirzadi0Doniel G. Drazin1Allison S. Strickland2Serguei I. Bannykh3J. Patrick Johnson4Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USADepartment of Neurosurgery, University of Oklahoma, Oklahoma City, OK 73104, USADepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USADepartment of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USAEsthesioneuroblastoma (ENB) is an uncommon aggressive malignant intranasal neoplasm that originates from neural crest cells of the olfactory epithelium. Although local invasion to the sinuses is common, spinal metastasis of ENB is rare with only 28 documented cases involving the spine spinal cord, or leptomeninges. We report a case of ENB with multiple drop metastases to the cervical and thoracic spine, and review the patient’s disease, medical history, and multiple interventions during a span of 15 years following the initial cranial resection. Despite aggressive multiple surgical resections, radiation, and chemotherapy, the tumor had significant progression and recurrence. The literature is reviewed, followed by a discussion of the natural progression of the disease and various reported interventions. Although a combination of surgery with chemotherapy and radiation therapy has been recommended, no definitive management has been established for ENB. Further research is needed to determine decisive treatment for metastatic ENB to the spine.http://dx.doi.org/10.1155/2013/107315 |
| spellingShingle | Ali S. Shirzadi Doniel G. Drazin Allison S. Strickland Serguei I. Bannykh J. Patrick Johnson Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup Case Reports in Surgery |
| title | Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup |
| title_full | Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup |
| title_fullStr | Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup |
| title_full_unstemmed | Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup |
| title_short | Vertebral Column Metastases from an Esthesioneuroblastoma: Chemotherapy, Radiation, and Resection for Recurrence with 15-Year Followup |
| title_sort | vertebral column metastases from an esthesioneuroblastoma chemotherapy radiation and resection for recurrence with 15 year followup |
| url | http://dx.doi.org/10.1155/2013/107315 |
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