Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis
Abstract Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This stu...
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| Format: | Article |
| Language: | English |
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Springer
2025-06-01
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| Series: | Journal of Materials Science: Materials in Medicine |
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| Online Access: | https://doi.org/10.1007/s10856-025-06905-3 |
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| author | Xiaoge Jiang Xinyi Chen Qiming Li Xinyi Li Kaiwen Zhang Jiazhen Jiang Xinrui Men Wei-Cho Chiou Song Chen |
| author_facet | Xiaoge Jiang Xinyi Chen Qiming Li Xinyi Li Kaiwen Zhang Jiazhen Jiang Xinrui Men Wei-Cho Chiou Song Chen |
| author_sort | Xiaoge Jiang |
| collection | DOAJ |
| description | Abstract Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This study focuses on the synthesis of polydopamine-coated reduced graphene oxide (RGO@PDA), designed to harness the anti-inflammatory properties of dopamine and the osteogenic potential of graphene oxide for synergistic periodontitis treatment. RGO@PDA was synthesized through a 12-h magnetic stirring process of graphene oxide and dopamine at room temperature. This water-dispersible and biocompatible compound demonstrated remarkable efficacy in enhancing osteogenic differentiation in rat bone mesenchymal stem cells (rBMSCs), evidenced by increased alkaline phosphatase activity, mineralization, and the upregulation of osteogenic genes and proteins. Furthermore, RGO@PDA showed significant capabilities in scavenging reactive oxygen species (ROS) and reducing proinflammatory factor expression. In vivo experiments revealed that RGO@PDA not only alleviated periodontal inflammation but also promoted alveolar bone repair in periodontitis-afflicted rats. These findings underscore RGO@PDA’s dual anti-inflammatory and osteogenic effects, highlighting its potential as a transformative treatment for periodontitis. Graphical Abstract |
| format | Article |
| id | doaj-art-d83eba094fc4472ebcb0741ec228d0cf |
| institution | Kabale University |
| issn | 1573-4838 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Springer |
| record_format | Article |
| series | Journal of Materials Science: Materials in Medicine |
| spelling | doaj-art-d83eba094fc4472ebcb0741ec228d0cf2025-08-20T03:45:11ZengSpringerJournal of Materials Science: Materials in Medicine1573-48382025-06-0136111810.1007/s10856-025-06905-3Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitisXiaoge Jiang0Xinyi Chen1Qiming Li2Xinyi Li3Kaiwen Zhang4Jiazhen Jiang5Xinrui Men6Wei-Cho Chiou7Song Chen8State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityState Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan UniversityAbstract Owing to its extremely high prevalence and the distressing consequence of tooth loss, periodontitis has attracted substantial research attention. In light of these conditions, graphene-based biomaterials have emerged as a potentially promising approach for periodontal regeneration. This study focuses on the synthesis of polydopamine-coated reduced graphene oxide (RGO@PDA), designed to harness the anti-inflammatory properties of dopamine and the osteogenic potential of graphene oxide for synergistic periodontitis treatment. RGO@PDA was synthesized through a 12-h magnetic stirring process of graphene oxide and dopamine at room temperature. This water-dispersible and biocompatible compound demonstrated remarkable efficacy in enhancing osteogenic differentiation in rat bone mesenchymal stem cells (rBMSCs), evidenced by increased alkaline phosphatase activity, mineralization, and the upregulation of osteogenic genes and proteins. Furthermore, RGO@PDA showed significant capabilities in scavenging reactive oxygen species (ROS) and reducing proinflammatory factor expression. In vivo experiments revealed that RGO@PDA not only alleviated periodontal inflammation but also promoted alveolar bone repair in periodontitis-afflicted rats. These findings underscore RGO@PDA’s dual anti-inflammatory and osteogenic effects, highlighting its potential as a transformative treatment for periodontitis. Graphical Abstracthttps://doi.org/10.1007/s10856-025-06905-3Graphene oxidePolydopamineOsteogenesisAnti-inflammationPeriodontitis |
| spellingShingle | Xiaoge Jiang Xinyi Chen Qiming Li Xinyi Li Kaiwen Zhang Jiazhen Jiang Xinrui Men Wei-Cho Chiou Song Chen Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis Journal of Materials Science: Materials in Medicine Graphene oxide Polydopamine Osteogenesis Anti-inflammation Periodontitis |
| title | Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis |
| title_full | Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis |
| title_fullStr | Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis |
| title_full_unstemmed | Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis |
| title_short | Synergistic effects of polydopamine-coated reduced graphene oxide on osteogenesis and anti-inflammation in periodontitis |
| title_sort | synergistic effects of polydopamine coated reduced graphene oxide on osteogenesis and anti inflammation in periodontitis |
| topic | Graphene oxide Polydopamine Osteogenesis Anti-inflammation Periodontitis |
| url | https://doi.org/10.1007/s10856-025-06905-3 |
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