Probiotics as Support for Antibiotic Therapy: Benefits and Risks
Antibiotic therapy, while effective in combating bacterial infections, can disrupt the gut microbiota, often leading to antibiotic-associated diarrhea (AAD). In this context, probiotics have been explored as potential adjuncts to alleviate these adverse effects. Research indicates that using probio...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nicolaus Copernicus University in Toruń
2025-05-01
|
| Series: | Quality in Sport |
| Subjects: | |
| Online Access: | https://apcz.umk.pl/QS/article/view/60214 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849322089731850240 |
|---|---|
| author | Kinga Dominiczak Katarzyna Szafrańska Aleksandra Mucha Ewa Chodkowska Natalia Jakubczyk Elżbieta Leszczyńska-Knaga Sylwia Graszka Aleksander Szeps Patrycja Dominiczak Kinga Bielas |
| author_facet | Kinga Dominiczak Katarzyna Szafrańska Aleksandra Mucha Ewa Chodkowska Natalia Jakubczyk Elżbieta Leszczyńska-Knaga Sylwia Graszka Aleksander Szeps Patrycja Dominiczak Kinga Bielas |
| author_sort | Kinga Dominiczak |
| collection | DOAJ |
| description |
Antibiotic therapy, while effective in combating bacterial infections, can disrupt the gut microbiota, often leading to antibiotic-associated diarrhea (AAD). In this context, probiotics have been explored as potential adjuncts to alleviate these adverse effects. Research indicates that using probiotics during antibiotic treatment may reduce the risk of AAD. For instance, a meta-analysis by Szajewska and Kołodziejczyk found that probiotics decrease the likelihood of AAD in adults, with higher doses being more effective than lower ones. However, the efficacy of probiotics in protecting the diversity of the gut microbiome during antibiotic therapy remains controversial. A systematic review and meta-analysis conducted by Matuskova et al. suggest that probiotic supplementation does not significantly prevent the reduction of gut microbiota diversity caused by antibiotics. Moreover, concerns about the safety of probiotics have been raised, particularly regarding the potential transfer of antibiotic resistance genes. A systematic review by Zhang et al. highlights the need for further research to evaluate the risks associated with the spread of antibiotic resistance through probiotic strains. Therefore, while probiotics may offer certain benefits as adjuncts to antibiotic therapy, it is essential to carefully consider the associated risks and conduct further studies to fully understand their impact on patient health.
|
| format | Article |
| id | doaj-art-d83d5af0f8e345fca810dff6834bbb2d |
| institution | Kabale University |
| issn | 2450-3118 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Nicolaus Copernicus University in Toruń |
| record_format | Article |
| series | Quality in Sport |
| spelling | doaj-art-d83d5af0f8e345fca810dff6834bbb2d2025-08-20T03:49:32ZengNicolaus Copernicus University in ToruńQuality in Sport2450-31182025-05-014110.12775/QS.2025.41.60214Probiotics as Support for Antibiotic Therapy: Benefits and RisksKinga Dominiczak0https://orcid.org/0009-0007-9507-9813Katarzyna Szafrańska1https://orcid.org/0009-0002-3403-034XAleksandra Mucha2https://orcid.org/0009-0008-8841-0958Ewa Chodkowska3https://orcid.org/0009-0003-1032-9248Natalia Jakubczyk4https://orcid.org/0009-0008-3190-4658Elżbieta Leszczyńska-Knaga5https://orcid.org/0009-0007-5584-8614Sylwia Graszka6https://orcid.org/0009-0005-1709-0254Aleksander Szepshttps://orcid.org/0009-0003-2166-0112Patrycja Dominiczak7https://orcid.org/0009-0002-6310-343XKinga Bielas8https://orcid.org/0009-0008-7151-94204th Military Clinical Hospital in Wroclaw, Weigla 5, 53-114 Wroclaw, Poland4th Military Clinical Hospital in Wroclaw, Weigla 5, 53-114 Wroclaw, PolandŚląski Uniwersytet Medyczny w Katowicach : Katowice, Silesia, PLŚląski Uniwersytet Medyczny w Katowicach : Katowice, Silesia, PLIndependent Public Health Care Facility of the Ministry of Internal Affairs and Administration in Łódź, Północna 42 street, 91-425 Łódź, Poland Megrez Provincial Specialist Hospital, Edukacja 102 street, 43-100 Tychy, Poland Wojewódzki Zespół Zakładów Opieki Zdrowotnej Centrum Leczenia Chorób Płuc i Rehabilitacji in Łódź, Poland, Okólna 181 StreetAkademia Wojsk Lądowych imienia generała Tadeusza KościuszkiŚląski Uniwersytet Medyczny w Katowicach : Katowice, Silesia, PL Antibiotic therapy, while effective in combating bacterial infections, can disrupt the gut microbiota, often leading to antibiotic-associated diarrhea (AAD). In this context, probiotics have been explored as potential adjuncts to alleviate these adverse effects. Research indicates that using probiotics during antibiotic treatment may reduce the risk of AAD. For instance, a meta-analysis by Szajewska and Kołodziejczyk found that probiotics decrease the likelihood of AAD in adults, with higher doses being more effective than lower ones. However, the efficacy of probiotics in protecting the diversity of the gut microbiome during antibiotic therapy remains controversial. A systematic review and meta-analysis conducted by Matuskova et al. suggest that probiotic supplementation does not significantly prevent the reduction of gut microbiota diversity caused by antibiotics. Moreover, concerns about the safety of probiotics have been raised, particularly regarding the potential transfer of antibiotic resistance genes. A systematic review by Zhang et al. highlights the need for further research to evaluate the risks associated with the spread of antibiotic resistance through probiotic strains. Therefore, while probiotics may offer certain benefits as adjuncts to antibiotic therapy, it is essential to carefully consider the associated risks and conduct further studies to fully understand their impact on patient health. https://apcz.umk.pl/QS/article/view/60214ProbioticsAntibioticsGastrointestinal microbiomeProbiotic safetyClostridioides difficileMicrobiome restoration |
| spellingShingle | Kinga Dominiczak Katarzyna Szafrańska Aleksandra Mucha Ewa Chodkowska Natalia Jakubczyk Elżbieta Leszczyńska-Knaga Sylwia Graszka Aleksander Szeps Patrycja Dominiczak Kinga Bielas Probiotics as Support for Antibiotic Therapy: Benefits and Risks Quality in Sport Probiotics Antibiotics Gastrointestinal microbiome Probiotic safety Clostridioides difficile Microbiome restoration |
| title | Probiotics as Support for Antibiotic Therapy: Benefits and Risks |
| title_full | Probiotics as Support for Antibiotic Therapy: Benefits and Risks |
| title_fullStr | Probiotics as Support for Antibiotic Therapy: Benefits and Risks |
| title_full_unstemmed | Probiotics as Support for Antibiotic Therapy: Benefits and Risks |
| title_short | Probiotics as Support for Antibiotic Therapy: Benefits and Risks |
| title_sort | probiotics as support for antibiotic therapy benefits and risks |
| topic | Probiotics Antibiotics Gastrointestinal microbiome Probiotic safety Clostridioides difficile Microbiome restoration |
| url | https://apcz.umk.pl/QS/article/view/60214 |
| work_keys_str_mv | AT kingadominiczak probioticsassupportforantibiotictherapybenefitsandrisks AT katarzynaszafranska probioticsassupportforantibiotictherapybenefitsandrisks AT aleksandramucha probioticsassupportforantibiotictherapybenefitsandrisks AT ewachodkowska probioticsassupportforantibiotictherapybenefitsandrisks AT nataliajakubczyk probioticsassupportforantibiotictherapybenefitsandrisks AT elzbietaleszczynskaknaga probioticsassupportforantibiotictherapybenefitsandrisks AT sylwiagraszka probioticsassupportforantibiotictherapybenefitsandrisks AT aleksanderszeps probioticsassupportforantibiotictherapybenefitsandrisks AT patrycjadominiczak probioticsassupportforantibiotictherapybenefitsandrisks AT kingabielas probioticsassupportforantibiotictherapybenefitsandrisks |