Administration of low intensity vibration and a RANKL inhibitor, alone or in combination, reduces bone loss after spinal cord injury-induced immobilization in rats

Administration of low intensity vibration and a RANKL inhibitor, alone or in combination, reduces bone loss after spinal cord injury-induced immobilization in rats

We previously reported an ability of low-intensity vibration (LIV) to improve selected biomarkers of bone turnover and gene expression and reduce osteoclastogenesis but lacking of evident bone accrual. In this study, we demonstrate that a prolonged course of LIV that initiated at 2 weeks post-injury...

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Bibliographic Details
Main Authors: Yuanzhen Peng, Helen M. Bramlett, W. Dalton Dietrich, Alex Marcillo, Juliana Sanchez-Molano, Ofelia Furones-Alonso, Jay J. Cao, Jenney Huang, Andrew A. Li, Jian Q. Feng, William A. Bauman, Weiping Qin
Format: Article
Language:English
Published: Elsevier 2024-12-01
Series:Bone Reports
Subjects:
Immobilization
Spinal cord injury
Low intensity vibration
RANKL inhibitor
Bone resorption
Bone formation
Online Access:http://www.sciencedirect.com/science/article/pii/S2352187224000755
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