HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection
Humans naturally divide their continuous experiences into discrete events, with event boundaries playing a critical role in this segmentation process. These boundaries are marked by significant shifts in brain activity, particularly in the hippocampal complex (HPC) and default mode network (DMN), wh...
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| Language: | English |
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Elsevier
2025-08-01
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| Series: | NeuroImage |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1053811925003313 |
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| author | Qiuyi Liu Siyang Li Lili Sun Zhipeng Li Peng Ren Wencai Ding Hongbo Bao Xia Liang |
| author_facet | Qiuyi Liu Siyang Li Lili Sun Zhipeng Li Peng Ren Wencai Ding Hongbo Bao Xia Liang |
| author_sort | Qiuyi Liu |
| collection | DOAJ |
| description | Humans naturally divide their continuous experiences into discrete events, with event boundaries playing a critical role in this segmentation process. These boundaries are marked by significant shifts in brain activity, particularly in the hippocampal complex (HPC) and default mode network (DMN), which are key to learning and memory formation. We hypothesized that neural event boundaries in specific HPC-DMN regions contribute to episode recollection through across-boundary BOLD pattern shifts and neural event network formation, which may be influenced by two factors: network integration and boundary alignment. To test this, we used the widely recognized Sherlock fMRI dataset, which involves 22 human participants (17 subjects were used in this study). One key finding was that across-boundary BOLD pattern dissimilarity in the inferior parietal lobule (IPL) was greater for successfully recalled events compared to unsuccessful ones, specifically at boundaries with a high participation coefficient (indicative of high integration) or those aligned with the anterior superior temporal gyrus (aSTG) or the ventrolateral prefrontal cortex (vlPFC). Moreover, the entorhinal cortex played a crucial role in linking events into a network to facilitate subsequent recollection, particularly at boundaries with low participation coefficients or those aligned with the parahippocampus (PHC). These findings highlight the vital role of neural event boundaries in aiding comprehension and memory in naturalistic contexts through interactions with other brain regions. |
| format | Article |
| id | doaj-art-d83a871ddf8f414ebd16fa54007f033e |
| institution | OA Journals |
| issn | 1095-9572 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | NeuroImage |
| spelling | doaj-art-d83a871ddf8f414ebd16fa54007f033e2025-08-20T02:36:52ZengElsevierNeuroImage1095-95722025-08-0131712132810.1016/j.neuroimage.2025.121328HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollectionQiuyi Liu0Siyang Li1Lili Sun2Zhipeng Li3Peng Ren4Wencai Ding5Hongbo Bao6Xia Liang7School of Life Science and Technology, HIT Faculty of Life Science and Medicine, Harbin Institute of Technology, Harbin 150001, China; Research Center for Social Computing and Interactive Robotics, Harbin Institute of Technology, Harbin 150001, ChinaZhejiang Lab, Hangzhou, Zhejiang 311100, ChinaSchool of Life Science and Technology, HIT Faculty of Life Science and Medicine, Harbin Institute of Technology, Harbin 150001, China; Research Center for Social Computing and Interactive Robotics, Harbin Institute of Technology, Harbin 150001, ChinaSchool of Life Science and Technology, HIT Faculty of Life Science and Medicine, Harbin Institute of Technology, Harbin 150001, China; Research Center for Social Computing and Interactive Robotics, Harbin Institute of Technology, Harbin 150001, ChinaInstitute of Science and Technology for Brain-Inspired Intelligence and Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200433, ChinaDepartment of Neurology, The Second Affiliated Hospital of Wannan Medical College, Wuhu 241002, ChinaDepartment of Neurosurgery, Harbin Medical University Cancer Hospital, Harbin 150081, China; Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, ChinaResearch Center for Social Computing and Interactive Robotics, Harbin Institute of Technology, Harbin 150001, China; Frontiers Science Center for Matter Behave in Space Environment, Harbin Institute of Technology, Harbin 150001, China; Corresponding author at: Research Center for Social Computing and Interactive Robotics, Harbin Institute of Technology, Harbin 150001, China.Humans naturally divide their continuous experiences into discrete events, with event boundaries playing a critical role in this segmentation process. These boundaries are marked by significant shifts in brain activity, particularly in the hippocampal complex (HPC) and default mode network (DMN), which are key to learning and memory formation. We hypothesized that neural event boundaries in specific HPC-DMN regions contribute to episode recollection through across-boundary BOLD pattern shifts and neural event network formation, which may be influenced by two factors: network integration and boundary alignment. To test this, we used the widely recognized Sherlock fMRI dataset, which involves 22 human participants (17 subjects were used in this study). One key finding was that across-boundary BOLD pattern dissimilarity in the inferior parietal lobule (IPL) was greater for successfully recalled events compared to unsuccessful ones, specifically at boundaries with a high participation coefficient (indicative of high integration) or those aligned with the anterior superior temporal gyrus (aSTG) or the ventrolateral prefrontal cortex (vlPFC). Moreover, the entorhinal cortex played a crucial role in linking events into a network to facilitate subsequent recollection, particularly at boundaries with low participation coefficients or those aligned with the parahippocampus (PHC). These findings highlight the vital role of neural event boundaries in aiding comprehension and memory in naturalistic contexts through interactions with other brain regions.http://www.sciencedirect.com/science/article/pii/S1053811925003313fMRINaturalisticEvent boundaryHippocampusDefault mode network |
| spellingShingle | Qiuyi Liu Siyang Li Lili Sun Zhipeng Li Peng Ren Wencai Ding Hongbo Bao Xia Liang HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection NeuroImage fMRI Naturalistic Event boundary Hippocampus Default mode network |
| title | HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection |
| title_full | HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection |
| title_fullStr | HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection |
| title_full_unstemmed | HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection |
| title_short | HPC-DMN integration at neural event boundary affects across-boundary BOLD representations and memory recollection |
| title_sort | hpc dmn integration at neural event boundary affects across boundary bold representations and memory recollection |
| topic | fMRI Naturalistic Event boundary Hippocampus Default mode network |
| url | http://www.sciencedirect.com/science/article/pii/S1053811925003313 |
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