Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects
Hyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This study reviews uric acid-lowering peptides from various source...
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| Format: | Article |
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MDPI AG
2024-12-01
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| Series: | Foods |
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| author | Yu Han Wanlu Liu Kexin Li Mingzhen Zhang Xinqi Liu Lu Li Zhao Guo He Li |
| author_facet | Yu Han Wanlu Liu Kexin Li Mingzhen Zhang Xinqi Liu Lu Li Zhao Guo He Li |
| author_sort | Yu Han |
| collection | DOAJ |
| description | Hyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This study reviews uric acid-lowering peptides from various sources, focusing on two pathways: inhibiting uric acid production and promoting excretion. Low-molecular-weight peptides (<1000 Da) exhibited superior uric acid-lowering effects. We further explored the relationships between amino acid composition and their target interactions. Peptides rich in cyclic amino acids (tryptophan, phenylalanine, and histidine) and containing small amounts of linear amino acids (leucine, cysteine, and glycine) demonstrated significant potential for lowering uric acid. These findings provide theoretical support for developing novel functional foods for the management of hyperuricemia. |
| format | Article |
| id | doaj-art-d839920012b844f989e1c697607b64b6 |
| institution | Kabale University |
| issn | 2304-8158 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | MDPI AG |
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| series | Foods |
| spelling | doaj-art-d839920012b844f989e1c697607b64b62025-01-10T13:17:39ZengMDPI AGFoods2304-81582024-12-011415810.3390/foods14010058Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural EffectsYu Han0Wanlu Liu1Kexin Li2Mingzhen Zhang3Xinqi Liu4Lu Li5Zhao Guo6He Li7Key Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaRushan Hualong Biotechnology Co., Ltd., Weihai 264500, ChinaKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaDepartment of Orthopaedics, The Affiliated Hospital of Hebei University, Baoding 071000, ChinaKey Laboratory of Geriatric Nutrition and Health, Beijing Technology and Business University, Ministry of Education, Beijing 100048, ChinaHyperuricemia, a disorder of purine metabolism associated with cardiovascular disease, gout, and kidney disease, can be alleviated by food-derived peptides. However, the precise mechanisms remain unclear, hindering their development. This study reviews uric acid-lowering peptides from various sources, focusing on two pathways: inhibiting uric acid production and promoting excretion. Low-molecular-weight peptides (<1000 Da) exhibited superior uric acid-lowering effects. We further explored the relationships between amino acid composition and their target interactions. Peptides rich in cyclic amino acids (tryptophan, phenylalanine, and histidine) and containing small amounts of linear amino acids (leucine, cysteine, and glycine) demonstrated significant potential for lowering uric acid. These findings provide theoretical support for developing novel functional foods for the management of hyperuricemia.https://www.mdpi.com/2304-8158/14/1/58bioactive peptidehyperuricemiaconstitutive relationshipmechanism of action |
| spellingShingle | Yu Han Wanlu Liu Kexin Li Mingzhen Zhang Xinqi Liu Lu Li Zhao Guo He Li Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects Foods bioactive peptide hyperuricemia constitutive relationship mechanism of action |
| title | Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects |
| title_full | Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects |
| title_fullStr | Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects |
| title_full_unstemmed | Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects |
| title_short | Investigating the Role of Food-Derived Peptides in Hyperuricemia: From Mechanisms of Action to Structural Effects |
| title_sort | investigating the role of food derived peptides in hyperuricemia from mechanisms of action to structural effects |
| topic | bioactive peptide hyperuricemia constitutive relationship mechanism of action |
| url | https://www.mdpi.com/2304-8158/14/1/58 |
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