Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries
Background: This study aimed to determine the findings of histological chorioamnionitis (HCA) that may lead to preterm labor. Methods: A total of 126 women who underwent cesarean delivery at our hospital’s obste...
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| Format: | Article |
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IMR Press
2025-06-01
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| Series: | Clinical and Experimental Obstetrics & Gynecology |
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| Online Access: | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG37550 |
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| author | Ahmet Ilker Eryilmaz Durmus Onder Meryem Busra Birsen Hasan Ali Inal Gulsah Inal Metin Kaba |
| author_facet | Ahmet Ilker Eryilmaz Durmus Onder Meryem Busra Birsen Hasan Ali Inal Gulsah Inal Metin Kaba |
| author_sort | Ahmet Ilker Eryilmaz |
| collection | DOAJ |
| description | Background: This study aimed to determine the findings of histological chorioamnionitis (HCA) that may lead to preterm labor. Methods: A total of 126 women who underwent cesarean delivery at our hospital’s obstetrics clinic between May 1 and December 31, 2022, were prospectively included in the study (Group 1, Term labor, n = 63, Group 2, Preterm labor, n = 63). Participants’ sociodemographic characteristics, laboratory results, and histopathological findings were documented and compared between the groups. Placentas were examined for the diagnosis of HCA by a senior pathologist. Results: Significant differences were observed between Group 1 and Group 2 in gestational age at delivery (38.6 ± 1.3 vs 33.6 ± 1.6 weeks, respectively; p < 0.001), Apgar scores at the first minute (8.8 ± 0.6 vs 8.1 ± 1.8; p < 0.001), and neonatal intensive care unit (NICU) admission (9.5% vs 42.9%; p < 0.001). Although hemoglobin (Hb) levels, mean platelet volume (MPV), mean corpuscular volume (MCV), and lymphocyte, neutrophil, monocyte, platelet counts, as well as the pan-inflammatory value at admission, were comparable between groups (p > 0.05), leukocyte counts (10,382.54 ± 2020.58 vs 12,133.33 ± 4936.01, respectively; p = 0.011), neutrophil-lymphocyte ratio (4.21 ± 1.60 vs 5.46 ± 1.48; p = 0.040), and C-reactive protein (CRP) values (6.46 ± 5.56 vs 15.90 ± 9.27 g/dL; p = 0.027) differed significantly between the two groups. The incidence of acute (7.9% vs 49.2%), mild (33.3% vs 49.2%), and moderate (3.2% vs 14.3%) chorioamnionitis was statistically significantly higher in the preterm labor group (p < 0.05). Conclusions: The study findings show that the prevalence of HCA is notably higher in pregnant women with preterm deliveries, and that both the neutrophil-to-lymphocyte ratio and CRP levels are higher in preterm compared to term deliveries. Further studies with larger cohorts are warranted to elucidate these associations. |
| format | Article |
| id | doaj-art-d8387af9c306452cadd12a3d9b131313 |
| institution | Kabale University |
| issn | 0390-6663 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Clinical and Experimental Obstetrics & Gynecology |
| spelling | doaj-art-d8387af9c306452cadd12a3d9b1313132025-08-20T03:33:15ZengIMR PressClinical and Experimental Obstetrics & Gynecology0390-66632025-06-015263755010.31083/CEOG37550S0390-6663(25)02608-9Comparison of Histological Chorioamnionitis Findings Between Term and Preterm DeliveriesAhmet Ilker Eryilmaz0Durmus Onder1Meryem Busra Birsen2Hasan Ali Inal3Gulsah Inal4Metin Kaba5Department of Obstetrics and Gynecology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyDepartment of Obstetrics and Gynecology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyDepartment of Obstetrics and Gynecology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyDepartment of Obstetrics and Gynecology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyDepartment of Pathology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyDepartment of Obstetrics and Gynecology, Antalya Training and Research Hospital, Health Science University, 07100 Antalya, TurkeyBackground: This study aimed to determine the findings of histological chorioamnionitis (HCA) that may lead to preterm labor. Methods: A total of 126 women who underwent cesarean delivery at our hospital’s obstetrics clinic between May 1 and December 31, 2022, were prospectively included in the study (Group 1, Term labor, n = 63, Group 2, Preterm labor, n = 63). Participants’ sociodemographic characteristics, laboratory results, and histopathological findings were documented and compared between the groups. Placentas were examined for the diagnosis of HCA by a senior pathologist. Results: Significant differences were observed between Group 1 and Group 2 in gestational age at delivery (38.6 ± 1.3 vs 33.6 ± 1.6 weeks, respectively; p < 0.001), Apgar scores at the first minute (8.8 ± 0.6 vs 8.1 ± 1.8; p < 0.001), and neonatal intensive care unit (NICU) admission (9.5% vs 42.9%; p < 0.001). Although hemoglobin (Hb) levels, mean platelet volume (MPV), mean corpuscular volume (MCV), and lymphocyte, neutrophil, monocyte, platelet counts, as well as the pan-inflammatory value at admission, were comparable between groups (p > 0.05), leukocyte counts (10,382.54 ± 2020.58 vs 12,133.33 ± 4936.01, respectively; p = 0.011), neutrophil-lymphocyte ratio (4.21 ± 1.60 vs 5.46 ± 1.48; p = 0.040), and C-reactive protein (CRP) values (6.46 ± 5.56 vs 15.90 ± 9.27 g/dL; p = 0.027) differed significantly between the two groups. The incidence of acute (7.9% vs 49.2%), mild (33.3% vs 49.2%), and moderate (3.2% vs 14.3%) chorioamnionitis was statistically significantly higher in the preterm labor group (p < 0.05). Conclusions: The study findings show that the prevalence of HCA is notably higher in pregnant women with preterm deliveries, and that both the neutrophil-to-lymphocyte ratio and CRP levels are higher in preterm compared to term deliveries. Further studies with larger cohorts are warranted to elucidate these associations.https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG37550chorioamnionitisc-reactive proteinpremature birth |
| spellingShingle | Ahmet Ilker Eryilmaz Durmus Onder Meryem Busra Birsen Hasan Ali Inal Gulsah Inal Metin Kaba Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries Clinical and Experimental Obstetrics & Gynecology chorioamnionitis c-reactive protein premature birth |
| title | Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries |
| title_full | Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries |
| title_fullStr | Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries |
| title_full_unstemmed | Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries |
| title_short | Comparison of Histological Chorioamnionitis Findings Between Term and Preterm Deliveries |
| title_sort | comparison of histological chorioamnionitis findings between term and preterm deliveries |
| topic | chorioamnionitis c-reactive protein premature birth |
| url | https://www.imrpress.com/journal/CEOG/52/6/10.31083/CEOG37550 |
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