Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors
Neuroendocrine tumors (NETs) have a high predilection for metastasizing to the liver and can cause severe debilitating symptoms adversely affecting quality of life. Although surgery remains the treatment of choice, many liver metastases are inoperable at presentation. Hepatic arterial embolization p...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | International Journal of Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2012/471203 |
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| author | Eric Lee H. Leon Pachter Umut Sarpel |
| author_facet | Eric Lee H. Leon Pachter Umut Sarpel |
| author_sort | Eric Lee |
| collection | DOAJ |
| description | Neuroendocrine tumors (NETs) have a high predilection for metastasizing to the liver and can cause severe debilitating symptoms adversely affecting quality of life. Although surgery remains the treatment of choice, many liver metastases are inoperable at presentation. Hepatic arterial embolization procedures take advantage of the arterial supply of NET metastases. The goals of these therapies are twofold: to increase overall survival by stabilizing tumor growth, and to reduce the morbidity in symptomatic patients. Patients treated with hepatic arterial embolization demonstrate longer progression-free survival and have 5-year survival rates of nearly 30%. The safety of repeat embolizations has also been proven in the setting of recurrent symptoms or progression of the disease. Despite not being curative, hepatic arterial embolization should be used in the management of NETs with liver metastases. Long-term survival is not uncommon, making aggressive palliation of symptoms an important component of treatment. |
| format | Article |
| id | doaj-art-d8385a14b77c4000a4c704e5057213eb |
| institution | Kabale University |
| issn | 2090-3448 2090-3456 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hepatology |
| spelling | doaj-art-d8385a14b77c4000a4c704e5057213eb2025-02-03T05:48:27ZengWileyInternational Journal of Hepatology2090-34482090-34562012-01-01201210.1155/2012/471203471203Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine TumorsEric Lee0H. Leon Pachter1Umut Sarpel2Surgical Oncology, Bellevue Hospital Center, 550 First Avenue, NBV 15 South 11, New York, NY 10016, USASurgical Oncology, Bellevue Hospital Center, 550 First Avenue, NBV 15 South 11, New York, NY 10016, USASurgical Oncology, Bellevue Hospital Center, 550 First Avenue, NBV 15 South 11, New York, NY 10016, USANeuroendocrine tumors (NETs) have a high predilection for metastasizing to the liver and can cause severe debilitating symptoms adversely affecting quality of life. Although surgery remains the treatment of choice, many liver metastases are inoperable at presentation. Hepatic arterial embolization procedures take advantage of the arterial supply of NET metastases. The goals of these therapies are twofold: to increase overall survival by stabilizing tumor growth, and to reduce the morbidity in symptomatic patients. Patients treated with hepatic arterial embolization demonstrate longer progression-free survival and have 5-year survival rates of nearly 30%. The safety of repeat embolizations has also been proven in the setting of recurrent symptoms or progression of the disease. Despite not being curative, hepatic arterial embolization should be used in the management of NETs with liver metastases. Long-term survival is not uncommon, making aggressive palliation of symptoms an important component of treatment.http://dx.doi.org/10.1155/2012/471203 |
| spellingShingle | Eric Lee H. Leon Pachter Umut Sarpel Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors International Journal of Hepatology |
| title | Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors |
| title_full | Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors |
| title_fullStr | Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors |
| title_full_unstemmed | Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors |
| title_short | Hepatic Arterial Embolization for the Treatment of Metastatic Neuroendocrine Tumors |
| title_sort | hepatic arterial embolization for the treatment of metastatic neuroendocrine tumors |
| url | http://dx.doi.org/10.1155/2012/471203 |
| work_keys_str_mv | AT ericlee hepaticarterialembolizationforthetreatmentofmetastaticneuroendocrinetumors AT hleonpachter hepaticarterialembolizationforthetreatmentofmetastaticneuroendocrinetumors AT umutsarpel hepaticarterialembolizationforthetreatmentofmetastaticneuroendocrinetumors |