Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review
Although primarily affecting the respiratory system, COVID-19 causes multiple organ damage. One of its grave consequences is a prothrombotic state that manifests as thrombotic, microthrombotic and thromboembolic events. Therefore, understanding the effect of antiplatelet and anticoagulation therapy...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2021-02-01
|
| Series: | Open Heart |
| Online Access: | https://openheart.bmj.com/content/8/1/e001628.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1846170463399575552 |
|---|---|
| author | Kamal Matli Raymond Farah Mario Maalouf Nibal Chamoun Christy Costanian Georges Ghanem |
| author_facet | Kamal Matli Raymond Farah Mario Maalouf Nibal Chamoun Christy Costanian Georges Ghanem |
| author_sort | Kamal Matli |
| collection | DOAJ |
| description | Although primarily affecting the respiratory system, COVID-19 causes multiple organ damage. One of its grave consequences is a prothrombotic state that manifests as thrombotic, microthrombotic and thromboembolic events. Therefore, understanding the effect of antiplatelet and anticoagulation therapy in the context of COVID-19 treatment is important. The aim of this rapid review was to highlight the role of thrombosis in COVID-19 and to provide new insights on the use of antithrombotic therapy in its management. A rapid systematic review was performed using preferred reporting items for systematic reviews. Papers published in English on antithrombotic agent use and COVID-19 complications were eligible. Results showed that the use of anticoagulants increased survival and reduced thromboembolic events in patients. However, despite the use of anticoagulants, patients still suffered thrombotic events likely due to heparin resistance. Data on antiplatelet use in combination with anticoagulants in the setting of COVID-19 are quite scarce. Current side effects of anticoagulation therapy emphasise the need to update treatment guidelines. In this rapid review, we address a possible modulatory role of antiplatelet and anticoagulant combination against COVID-19 pathogenesis. This combination may be an effective form of adjuvant therapy against COVID-19 infection. However, further studies are needed to elucidate potential risks and benefits associated with this combination. |
| format | Article |
| id | doaj-art-d83798a7bc214c97a56466dfd57508db |
| institution | Kabale University |
| issn | 2053-3624 |
| language | English |
| publishDate | 2021-02-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | Open Heart |
| spelling | doaj-art-d83798a7bc214c97a56466dfd57508db2024-11-11T23:20:08ZengBMJ Publishing GroupOpen Heart2053-36242021-02-018110.1136/openhrt-2021-001628Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid reviewKamal Matli0Raymond Farah1Mario Maalouf2Nibal Chamoun3Christy Costanian4Georges Ghanem5Cardiology, Lebanese American University Medical Center-Rizk Hospital, Beirut, LebanonDepartment of Sciences, Lebanese University, Beirut, LebanonSchool of Medicine, Lebanese American University, Byblos, LebanonDepartment of Pharmacy Practice, Lebanese American University School of Pharmacy, Byblos, LebanonSchool of Medicine, Lebanese American University, Byblos, LebanonCardiology, Lebanese American University Medical Center-Rizk Hospital, Beirut, LebanonAlthough primarily affecting the respiratory system, COVID-19 causes multiple organ damage. One of its grave consequences is a prothrombotic state that manifests as thrombotic, microthrombotic and thromboembolic events. Therefore, understanding the effect of antiplatelet and anticoagulation therapy in the context of COVID-19 treatment is important. The aim of this rapid review was to highlight the role of thrombosis in COVID-19 and to provide new insights on the use of antithrombotic therapy in its management. A rapid systematic review was performed using preferred reporting items for systematic reviews. Papers published in English on antithrombotic agent use and COVID-19 complications were eligible. Results showed that the use of anticoagulants increased survival and reduced thromboembolic events in patients. However, despite the use of anticoagulants, patients still suffered thrombotic events likely due to heparin resistance. Data on antiplatelet use in combination with anticoagulants in the setting of COVID-19 are quite scarce. Current side effects of anticoagulation therapy emphasise the need to update treatment guidelines. In this rapid review, we address a possible modulatory role of antiplatelet and anticoagulant combination against COVID-19 pathogenesis. This combination may be an effective form of adjuvant therapy against COVID-19 infection. However, further studies are needed to elucidate potential risks and benefits associated with this combination.https://openheart.bmj.com/content/8/1/e001628.full |
| spellingShingle | Kamal Matli Raymond Farah Mario Maalouf Nibal Chamoun Christy Costanian Georges Ghanem Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review Open Heart |
| title | Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review |
| title_full | Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review |
| title_fullStr | Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review |
| title_full_unstemmed | Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review |
| title_short | Role of combining anticoagulant and antiplatelet agents in COVID-19 treatment: a rapid review |
| title_sort | role of combining anticoagulant and antiplatelet agents in covid 19 treatment a rapid review |
| url | https://openheart.bmj.com/content/8/1/e001628.full |
| work_keys_str_mv | AT kamalmatli roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview AT raymondfarah roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview AT mariomaalouf roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview AT nibalchamoun roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview AT christycostanian roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview AT georgesghanem roleofcombininganticoagulantandantiplateletagentsincovid19treatmentarapidreview |