FLT3-ITD promotes immune checkpoint CD80 via ROS elevation in acute myeloid leukemia

FLT3-ITD promotes immune checkpoint CD80 via ROS elevation in acute myeloid leukemia

Acute myeloid leukemia (AML), a malignant hematological stem cell disease, arises from the malignant transformation of myeloid progenitor cells. Among the genetic aberrations in AML, mutations in the tyrosine kinase receptor FLT3, especially FLT3-ITD, are most frequently detected and are correlated...

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Bibliographic Details
Main Authors: Libo Yan, Weiming Zhang, Qiyan Mo, Daogang Wang, Ning Xu, Mengzhe Yang, Tao Ren
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Subjects:
immune checkpoint
CD80
ROS
FLT3-ITD
leukemia
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1577313/full
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