The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice
Mycophenolate mofetil (MMF, cellcept) is widely used in maintenance immunosuppressive therapy for prevention refractory rejection in sold organ transplant recipients. MMF is orally used, and rapidly metabolized to its active constituent Mycophenolic acid. MPA is an inhibitor of Inosine Monophosphat...
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| Language: | English |
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Tikrit University
2019-12-01
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| Series: | Tikrit Journal of Pure Science |
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| Online Access: | https://tjpsj.org/index.php/tjps/article/view/453 |
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| author | RUIDA WATHEQ NEAMA WAJDI SABEEH SADEQ |
| author_facet | RUIDA WATHEQ NEAMA WAJDI SABEEH SADEQ |
| author_sort | RUIDA WATHEQ NEAMA |
| collection | DOAJ |
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Mycophenolate mofetil (MMF, cellcept) is widely used in maintenance immunosuppressive therapy for prevention refractory rejection in sold organ transplant recipients. MMF is orally used, and rapidly metabolized to its active constituent Mycophenolic acid. MPA is an inhibitor of Inosine Monophosphate Dehydrogenase ΙΙ (IMPDH ΙΙ) in lymphocyte causing in reduction in intracellular guanine nucleotide pools and leads to inhibition of lymphocyte proliferation. MMF is considered to be an effective and safe immunosuppressive agent compared with other medicins. MMF lacks the nephrotoxicity. But it has important side effects, gastrointestinal and heamatological adverse effects are the most common. The results of this study show the high significant in total chromosome aberrations in treatment groups compared with control. Also there is high significant differences in total damage DNA in treatment groups than control. In conclusion, MMF may has a high genotoxicity by induced chromosome aberration and DNA damage.
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| format | Article |
| id | doaj-art-d834ece9adbd412d9557cb5428e8dde8 |
| institution | OA Journals |
| issn | 1813-1662 2415-1726 |
| language | English |
| publishDate | 2019-12-01 |
| publisher | Tikrit University |
| record_format | Article |
| series | Tikrit Journal of Pure Science |
| spelling | doaj-art-d834ece9adbd412d9557cb5428e8dde82025-08-20T02:37:09ZengTikrit UniversityTikrit Journal of Pure Science1813-16622415-17262019-12-0124710.25130/tjps.v24i7.453The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus MiceRUIDA WATHEQ NEAMAWAJDI SABEEH SADEQ Mycophenolate mofetil (MMF, cellcept) is widely used in maintenance immunosuppressive therapy for prevention refractory rejection in sold organ transplant recipients. MMF is orally used, and rapidly metabolized to its active constituent Mycophenolic acid. MPA is an inhibitor of Inosine Monophosphate Dehydrogenase ΙΙ (IMPDH ΙΙ) in lymphocyte causing in reduction in intracellular guanine nucleotide pools and leads to inhibition of lymphocyte proliferation. MMF is considered to be an effective and safe immunosuppressive agent compared with other medicins. MMF lacks the nephrotoxicity. But it has important side effects, gastrointestinal and heamatological adverse effects are the most common. The results of this study show the high significant in total chromosome aberrations in treatment groups compared with control. Also there is high significant differences in total damage DNA in treatment groups than control. In conclusion, MMF may has a high genotoxicity by induced chromosome aberration and DNA damage. https://tjpsj.org/index.php/tjps/article/view/453Immunosuppressive therapyMycophenolate Mofetilgenotoxicitychromosome aberrationscomet assay |
| spellingShingle | RUIDA WATHEQ NEAMA WAJDI SABEEH SADEQ The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice Tikrit Journal of Pure Science Immunosuppressive therapy Mycophenolate Mofetil genotoxicity chromosome aberrations comet assay |
| title | The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice |
| title_full | The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice |
| title_fullStr | The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice |
| title_full_unstemmed | The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice |
| title_short | The ability of Mycophenolate Mofetil to induce chromosome aberration and DNA damage in Mus Musculus Mice |
| title_sort | ability of mycophenolate mofetil to induce chromosome aberration and dna damage in mus musculus mice |
| topic | Immunosuppressive therapy Mycophenolate Mofetil genotoxicity chromosome aberrations comet assay |
| url | https://tjpsj.org/index.php/tjps/article/view/453 |
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