Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity
Abstract. The paper discusses specific features of acute respiratory infections (ARI) progression in patients with comorbidity. The relevance of this study is accounted for by severe progression of ARIs in this group of patients, as well as by specific considerations of combining causal treatment of...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»
2020-06-01
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| Series: | Безопасность и риск фармакотерапии |
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| Online Access: | https://www.risksafety.ru/jour/article/view/181 |
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| author | T. A. Ruzhencova Daria А. Khavkina Natalia A. Meshkova Pavel V. Chukhliaev Alexander A. Garbuzov |
| author_facet | T. A. Ruzhencova Daria А. Khavkina Natalia A. Meshkova Pavel V. Chukhliaev Alexander A. Garbuzov |
| author_sort | T. A. Ruzhencova |
| collection | DOAJ |
| description | Abstract. The paper discusses specific features of acute respiratory infections (ARI) progression in patients with comorbidity. The relevance of this study is accounted for by severe progression of ARIs in this group of patients, as well as by specific considerations of combining causal treatment of infections with life-long treatment of chronic diseases.The aim of the study was to use a clinical case to substantiate an optimal treatment strategy for influenza and associated complications in a comorbid patient.Results: the analysis of the clinical case showed that an unfavourable course of ARI in the patient was due to the lack of timely antiviral therapy, adverse effects of paracetamol during statin therapy, exposure to pneumonia pathogen degradation products, general intoxication, and immune response. The compromised medical history contributed to the development of severe complications. The paper proposes a strategy for selecting the most eff ective and safe approach to the treatment of ARIs in a comorbid patient.Conclusions: ARIs in patients with chronic diseases entail increased risks of complications that may arise both due to specific characteristics of the infection and unfavourable combination of drugs. Treatment regimens for infl uenza and other ARIs in comorbid patients should be eff ective and timely. Early antiviral treatment is especially important in patients with comorbidity. When choosing a treatment regimen, it is necessary to assess potential benefi ts of pharmacotherapy as well as associated risks, including those related to previously prescribed medicines. |
| format | Article |
| id | doaj-art-d82a43de104e46f29ba17deeb6844d70 |
| institution | Kabale University |
| issn | 2312-7821 2619-1164 |
| language | Russian |
| publishDate | 2020-06-01 |
| publisher | Ministry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products» |
| record_format | Article |
| series | Безопасность и риск фармакотерапии |
| spelling | doaj-art-d82a43de104e46f29ba17deeb6844d702025-08-20T03:43:01ZrusMinistry of Health of the Russian Federation, Federal State Budgetary Institution «Scientific Centre for Expert Evaluation of Medicinal Products»Безопасность и риск фармакотерапии2312-78212619-11642020-06-0182778310.30895/2312-7821-2020-8-2-77-83163Strategy of Rational Therapy of Acute Respiratory Infections in Patients with ComorbidityT. A. Ruzhencova0Daria А. Khavkina1Natalia A. Meshkova2Pavel V. Chukhliaev3Alexander A. Garbuzov4Central Research Institute of EpidemiologyCentral Research Institute of EpidemiologyI. M. Sechenov First Moscow State Medical UniversityCentral Research Institute of EpidemiologyCentral Research Institute of EpidemiologyAbstract. The paper discusses specific features of acute respiratory infections (ARI) progression in patients with comorbidity. The relevance of this study is accounted for by severe progression of ARIs in this group of patients, as well as by specific considerations of combining causal treatment of infections with life-long treatment of chronic diseases.The aim of the study was to use a clinical case to substantiate an optimal treatment strategy for influenza and associated complications in a comorbid patient.Results: the analysis of the clinical case showed that an unfavourable course of ARI in the patient was due to the lack of timely antiviral therapy, adverse effects of paracetamol during statin therapy, exposure to pneumonia pathogen degradation products, general intoxication, and immune response. The compromised medical history contributed to the development of severe complications. The paper proposes a strategy for selecting the most eff ective and safe approach to the treatment of ARIs in a comorbid patient.Conclusions: ARIs in patients with chronic diseases entail increased risks of complications that may arise both due to specific characteristics of the infection and unfavourable combination of drugs. Treatment regimens for infl uenza and other ARIs in comorbid patients should be eff ective and timely. Early antiviral treatment is especially important in patients with comorbidity. When choosing a treatment regimen, it is necessary to assess potential benefi ts of pharmacotherapy as well as associated risks, including those related to previously prescribed medicines.https://www.risksafety.ru/jour/article/view/181acute respiratory infectionsinfluenzacardiovascular diseasesparacetamolantimicrobial drugsantiviralsstatinsadverse reactions |
| spellingShingle | T. A. Ruzhencova Daria А. Khavkina Natalia A. Meshkova Pavel V. Chukhliaev Alexander A. Garbuzov Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity Безопасность и риск фармакотерапии acute respiratory infections influenza cardiovascular diseases paracetamol antimicrobial drugs antivirals statins adverse reactions |
| title | Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity |
| title_full | Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity |
| title_fullStr | Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity |
| title_full_unstemmed | Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity |
| title_short | Strategy of Rational Therapy of Acute Respiratory Infections in Patients with Comorbidity |
| title_sort | strategy of rational therapy of acute respiratory infections in patients with comorbidity |
| topic | acute respiratory infections influenza cardiovascular diseases paracetamol antimicrobial drugs antivirals statins adverse reactions |
| url | https://www.risksafety.ru/jour/article/view/181 |
| work_keys_str_mv | AT taruzhencova strategyofrationaltherapyofacuterespiratoryinfectionsinpatientswithcomorbidity AT dariaakhavkina strategyofrationaltherapyofacuterespiratoryinfectionsinpatientswithcomorbidity AT nataliaameshkova strategyofrationaltherapyofacuterespiratoryinfectionsinpatientswithcomorbidity AT pavelvchukhliaev strategyofrationaltherapyofacuterespiratoryinfectionsinpatientswithcomorbidity AT alexanderagarbuzov strategyofrationaltherapyofacuterespiratoryinfectionsinpatientswithcomorbidity |