Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats
IntroductionMetabolic-associated fatty liver disease (MAFLD) is a liver disease syndrome. The total flavonoids of Dracocephalum moldavica L. (D. moldavica), the main active components of D. moldavica, have been demonstrated not only to have anti-inflammatory and antioxidant effects but also to regul...
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Frontiers Media S.A.
2025-05-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2025.1549515/full |
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| author | Xiaoyu Sun Na Ge Qingqing Liang Qian Wang Hui Yu Min Jin |
| author_facet | Xiaoyu Sun Na Ge Qingqing Liang Qian Wang Hui Yu Min Jin |
| author_sort | Xiaoyu Sun |
| collection | DOAJ |
| description | IntroductionMetabolic-associated fatty liver disease (MAFLD) is a liver disease syndrome. The total flavonoids of Dracocephalum moldavica L. (D. moldavica), the main active components of D. moldavica, have been demonstrated not only to have anti-inflammatory and antioxidant effects but also to regulate gut microbiota. However, the mechanism by which it improves MAFLD is unclear. So we want to investigate how the total flavonoids of D. moldavica alleviate high-fat diet (HFD)-induced MAFLD in rats.MethodsFirstly, MAFLD rat models were established by feeding with HFD, while the total flavonoids of D. moldavica were administered via gavage. Then, the experiments analyzed the changes of gut microbiota by the 16S rRNA sequencing and detected intestinal barrier permeability and liver inflammation to explore the mechanism of the total flavonoids of D. moldavica in the prevention and treatment of MAFLD.ResultsWe found that the total flavonoids of D. moldavica reduced systemic inflammation and could alleviate serum and liver lipid metabolism disorders in MAFLD rats. The results of the 16S rRNA sequencing demonstrated that the total flavonoids of D. moldavica increased the abundance and diversity of gut microbiota. Furthermore, the total flavonoids of D. moldavica have been demonstrated to enhance the intestinal mucosal barrier function, reduce LPS translocation, and inhibit the activation of hepatic TLR4/MyD88/NF-κB pathway. This could effectively ameliorate the hepatic lesions in MAFLD rats.ConclusionsThe aforementioned outcomes indicate that the total flavonoids ofD moldavica may potentially alleviate MAFLD by modulating gut microbiota, intestinal mucosal barrier and hepatic inflammation. |
| format | Article |
| id | doaj-art-d824531aa86a44cfbf6df7eb657932f4 |
| institution | OA Journals |
| issn | 1663-9812 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Pharmacology |
| spelling | doaj-art-d824531aa86a44cfbf6df7eb657932f42025-08-20T02:31:27ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122025-05-011610.3389/fphar.2025.15495151549515Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in ratsXiaoyu Sun0Na Ge1Qingqing Liang2Qian Wang3Hui Yu4Min Jin5The School of Public Health, Baotou Medical College, Baotou, ChinaThe School of Public Health, Baotou Medical College, Baotou, ChinaThe School of Public Health, Baotou Medical College, Baotou, ChinaThe School of Public Health, Baotou Medical College, Baotou, ChinaThe School of Basic Medicine and Forensic Sciences, Baotou Medical College, Baotou, ChinaThe School of Public Health, Baotou Medical College, Baotou, ChinaIntroductionMetabolic-associated fatty liver disease (MAFLD) is a liver disease syndrome. The total flavonoids of Dracocephalum moldavica L. (D. moldavica), the main active components of D. moldavica, have been demonstrated not only to have anti-inflammatory and antioxidant effects but also to regulate gut microbiota. However, the mechanism by which it improves MAFLD is unclear. So we want to investigate how the total flavonoids of D. moldavica alleviate high-fat diet (HFD)-induced MAFLD in rats.MethodsFirstly, MAFLD rat models were established by feeding with HFD, while the total flavonoids of D. moldavica were administered via gavage. Then, the experiments analyzed the changes of gut microbiota by the 16S rRNA sequencing and detected intestinal barrier permeability and liver inflammation to explore the mechanism of the total flavonoids of D. moldavica in the prevention and treatment of MAFLD.ResultsWe found that the total flavonoids of D. moldavica reduced systemic inflammation and could alleviate serum and liver lipid metabolism disorders in MAFLD rats. The results of the 16S rRNA sequencing demonstrated that the total flavonoids of D. moldavica increased the abundance and diversity of gut microbiota. Furthermore, the total flavonoids of D. moldavica have been demonstrated to enhance the intestinal mucosal barrier function, reduce LPS translocation, and inhibit the activation of hepatic TLR4/MyD88/NF-κB pathway. This could effectively ameliorate the hepatic lesions in MAFLD rats.ConclusionsThe aforementioned outcomes indicate that the total flavonoids ofD moldavica may potentially alleviate MAFLD by modulating gut microbiota, intestinal mucosal barrier and hepatic inflammation.https://www.frontiersin.org/articles/10.3389/fphar.2025.1549515/fullMAFLDintestinal mucosal barrierTLR4/MyD88/NF-κBliver impairmentgut microbiota |
| spellingShingle | Xiaoyu Sun Na Ge Qingqing Liang Qian Wang Hui Yu Min Jin Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats Frontiers in Pharmacology MAFLD intestinal mucosal barrier TLR4/MyD88/NF-κB liver impairment gut microbiota |
| title | Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats |
| title_full | Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats |
| title_fullStr | Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats |
| title_full_unstemmed | Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats |
| title_short | Effect of the total flavonoids of Dracocephalum moldavica L. on metabolic associated fatty liver disease in rats |
| title_sort | effect of the total flavonoids of dracocephalum moldavica l on metabolic associated fatty liver disease in rats |
| topic | MAFLD intestinal mucosal barrier TLR4/MyD88/NF-κB liver impairment gut microbiota |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2025.1549515/full |
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