Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia
Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients’ series...
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Wiley
2013-01-01
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| Series: | Advances in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2013/359071 |
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| author | Katerina Sarris Dimitrios Maltezas Efstathios Koulieris Vassiliki Bartzis Tatiana Tzenou Sotirios Sachanas Eftychia Nikolaou Anna Efthymiou Katerina Bitsani Maria Dimou Theodoros P. Vassilakopoulos Marina Siakantaris Maria K. Angelopoulou Flora Kontopidou Panagiotis Tsaftaridis Nikolitsa Kafasi Gerasimos A. Pangalis Panayiotis P. Panayiotidis Stephen Harding Marie-Christine Kyrtsonis |
| author_facet | Katerina Sarris Dimitrios Maltezas Efstathios Koulieris Vassiliki Bartzis Tatiana Tzenou Sotirios Sachanas Eftychia Nikolaou Anna Efthymiou Katerina Bitsani Maria Dimou Theodoros P. Vassilakopoulos Marina Siakantaris Maria K. Angelopoulou Flora Kontopidou Panagiotis Tsaftaridis Nikolitsa Kafasi Gerasimos A. Pangalis Panayiotis P. Panayiotidis Stephen Harding Marie-Christine Kyrtsonis |
| author_sort | Katerina Sarris |
| collection | DOAJ |
| description | Background. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients’ series. Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treatment, while 37 became symptomatic during follow-up. Seventy-two percent, 18%, and 10% were in Binet stage A, B and C, respectively. Median patients’ followup was 32 months (range 4–228). Results. Increased involved (restricted) sFLC (iFLC) was found in 42% of patients, while the summated FLC-kappa plus FLC-lambda was above 60 mg/dL in 14%. Increased sFLC values as well as those of summated FLC above 60 were related to shorter time to treatment (P=0.0005 and P=0.000003, resp.) and overall survival (P=0.05 and P=0.003, resp.). They also correlated with β2-microglobulin (P=0.009 and P=0.03, resp.), serum albumin (P=0.009 for summated sFLC), hemoglobin (P<0.001), abnormal LDH (P=0.037 and P=0.001, resp.), Binet stage (P<0.05) and with the presence of beta symptoms (P=0.004 for summated sFLC). Conclusion. We confirmed the prognostic significance of sFLC in CLL regarding both time to treatment and survival and showed their relationship with other parameters. |
| format | Article |
| id | doaj-art-d82223f2c58d4b26b22bb13161dd5722 |
| institution | DOAJ |
| issn | 1687-9104 1687-9112 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
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| series | Advances in Hematology |
| spelling | doaj-art-d82223f2c58d4b26b22bb13161dd57222025-08-20T03:23:51ZengWileyAdvances in Hematology1687-91041687-91122013-01-01201310.1155/2013/359071359071Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic LeukemiaKaterina Sarris0Dimitrios Maltezas1Efstathios Koulieris2Vassiliki Bartzis3Tatiana Tzenou4Sotirios Sachanas5Eftychia Nikolaou6Anna Efthymiou7Katerina Bitsani8Maria Dimou9Theodoros P. Vassilakopoulos10Marina Siakantaris11Maria K. Angelopoulou12Flora Kontopidou13Panagiotis Tsaftaridis14Nikolitsa Kafasi15Gerasimos A. Pangalis16Panayiotis P. Panayiotidis17Stephen Harding18Marie-Christine Kyrtsonis19Hematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceImmunology Department, Laikon General Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceThe Binding Site Ltd, B15 1QT, Birmingham, UKHematology Section of the First Department of Propedeutic Internal Medicine, Laikon University Hospital, Agiou Thoma 17, 11527 Athens, GreeceBackground. Serum free light chains (sFLC), the most commonly detected paraprotein in CLL, were recently proposed as useful tools for the prognostication of CLL patients. Objective. To investigate the prognostic implication of sFLC and the summated FLC-kappa plus FLC-lambda in a CLL patients’ series. Patients and Methods. We studied 143 CLL patients of which 18 were symptomatic and needed treatment, while 37 became symptomatic during follow-up. Seventy-two percent, 18%, and 10% were in Binet stage A, B and C, respectively. Median patients’ followup was 32 months (range 4–228). Results. Increased involved (restricted) sFLC (iFLC) was found in 42% of patients, while the summated FLC-kappa plus FLC-lambda was above 60 mg/dL in 14%. Increased sFLC values as well as those of summated FLC above 60 were related to shorter time to treatment (P=0.0005 and P=0.000003, resp.) and overall survival (P=0.05 and P=0.003, resp.). They also correlated with β2-microglobulin (P=0.009 and P=0.03, resp.), serum albumin (P=0.009 for summated sFLC), hemoglobin (P<0.001), abnormal LDH (P=0.037 and P=0.001, resp.), Binet stage (P<0.05) and with the presence of beta symptoms (P=0.004 for summated sFLC). Conclusion. We confirmed the prognostic significance of sFLC in CLL regarding both time to treatment and survival and showed their relationship with other parameters.http://dx.doi.org/10.1155/2013/359071 |
| spellingShingle | Katerina Sarris Dimitrios Maltezas Efstathios Koulieris Vassiliki Bartzis Tatiana Tzenou Sotirios Sachanas Eftychia Nikolaou Anna Efthymiou Katerina Bitsani Maria Dimou Theodoros P. Vassilakopoulos Marina Siakantaris Maria K. Angelopoulou Flora Kontopidou Panagiotis Tsaftaridis Nikolitsa Kafasi Gerasimos A. Pangalis Panayiotis P. Panayiotidis Stephen Harding Marie-Christine Kyrtsonis Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia Advances in Hematology |
| title | Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia |
| title_full | Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia |
| title_fullStr | Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia |
| title_full_unstemmed | Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia |
| title_short | Prognostic Significance of Serum Free Light Chains in Chronic Lymphocytic Leukemia |
| title_sort | prognostic significance of serum free light chains in chronic lymphocytic leukemia |
| url | http://dx.doi.org/10.1155/2013/359071 |
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