A potential surrogate for poliovirus in testing the efficacy of hand antiseptics according to the Global Poliovirus Containment Action Plan

A potential surrogate for poliovirus in testing the efficacy of hand antiseptics according to the Global Poliovirus Containment Action Plan

Introduction: As part of the global poliovirus containment program (Global Polio Eradication Initiative, GPEI), European laboratories are increasingly restricted from using the long-established poliovirus type 1 strain LSc-2ab as the reference virus in virucidal efficacy testing of disinfectants. T...

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Bibliographic Details
Main Authors: Eggers, Maren, Konrat, Katharina, Hübner, Nils, Schwebke, Ingeborg
Format: Article
Language:deu
Published: German Medical Science GMS Publishing House 2025-07-01
Series:GMS Hygiene and Infection Control
Subjects:
poliovirus containment
picornaviridae
encephalomyocarditis virus
virucidal efficacy
disinfectant testing
surrogate virus
quantitative suspension test
Online Access:https://journals.publisso.de/en/journals/hic/volume20/dgkh000568
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Summary:Introduction: As part of the global poliovirus containment program (Global Polio Eradication Initiative, GPEI), European laboratories are increasingly restricted from using the long-established poliovirus type 1 strain LSc-2ab as the reference virus in virucidal efficacy testing of disinfectants. This necessitates the identification of an alternative test virus that closely resembles poliovirus in its chemical resistance, belongs to the picornaviridae family, and is suitable for routine laboratory handling. Materials and methods: In this study, two strains of encephalomyocarditis virus (EMCV) were evaluated as potential substitutes in quantitative suspension tests (according to EN 14476) using five biocidal active substances: ethanol, propan-1-ol, propan-2-ol, glutaral (glutaraldehyde) and peracetic acid. Results: The results demonstrated a strong correlation between the inactivation profiles of EMCV and Sabin poliovirus type 1 vaccine strain LSc-2ab. Due to this close correlation and EMCV’s practical advantages in laboratory settings such as availability in a European virus bank, growth in a high titer, it is proposed as a suitable substitution candidate for future virucidal efficacy testing.
ISSN:2196-5226

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