Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma
Background: In the 21st century, the main cause of death in both sexes worldwide are cardiovascular diseases, in second place are neoplasms. In the case of women, the fourth cause of mortality is breast cancer despite the screening. Objective: Understanding the epigenetic mechanisms associated with...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2025-05-01
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| Series: | Basic & Clinical Cancer Research |
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| Online Access: | https://bccr.tums.ac.ir/index.php/bccrj/article/view/499 |
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| author | Josué Mondragón-Morales Rogelio Rogel-Alvarado Iris Alejandra Noverón-Figueroa Max Morales-Gutiérrez |
| author_facet | Josué Mondragón-Morales Rogelio Rogel-Alvarado Iris Alejandra Noverón-Figueroa Max Morales-Gutiérrez |
| author_sort | Josué Mondragón-Morales |
| collection | DOAJ |
| description | Background: In the 21st century, the main cause of death in both sexes worldwide are cardiovascular diseases, in second place are neoplasms. In the case of women, the fourth cause of mortality is breast cancer despite the screening. Objective: Understanding the epigenetic mechanisms associated with cervical cancer progression and metastasis, considering its correlation with poor prognosis. Methods: To prepare the present article, the search was done on platforms PubMed and Google Scholar, the search was carried out using the following medical subject headings (MeSH) in the search engine: “metastatic cervical cancer”, “cervical cancer epigenetics”, “cervical cancer genetics”, “cervical cancer mirnas”, “cervical cancer lncrnas”, “cervical cancer clinical trials” and “metastatic cervical cancer hpv”, in combination with boolean connectors ‘AND’ and ‘OR’. A total of 114 articles were reviewed, published between 1989 and 2022. Results and conclusions: It is essential to understand and know the epigenetic mechanisms associated with the cervical cancer pathogenesis and progression, to create new targeted treatment schemes for metastatic cervical cancer to reduce the mortality rate and increase disease-free survival.
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| format | Article |
| id | doaj-art-d81ad7bfa33e492fb951b95314feb5c8 |
| institution | Kabale University |
| issn | 2228-6527 2228-5466 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Basic & Clinical Cancer Research |
| spelling | doaj-art-d81ad7bfa33e492fb951b95314feb5c82025-08-20T04:02:32ZengTehran University of Medical SciencesBasic & Clinical Cancer Research2228-65272228-54662025-05-0116110.18502/bccr.v16i1.18752Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinomaJosué Mondragón-Morales0Rogelio Rogel-Alvarado1Iris Alejandra Noverón-Figueroa2Max Morales-Gutiérrez3Instituto Politécnico NacionalFacultad de Enfermería y ObstetriciaEscuela Superior de Medicina, Instituto Politécnico NacionalUniversidad WesthillBackground: In the 21st century, the main cause of death in both sexes worldwide are cardiovascular diseases, in second place are neoplasms. In the case of women, the fourth cause of mortality is breast cancer despite the screening. Objective: Understanding the epigenetic mechanisms associated with cervical cancer progression and metastasis, considering its correlation with poor prognosis. Methods: To prepare the present article, the search was done on platforms PubMed and Google Scholar, the search was carried out using the following medical subject headings (MeSH) in the search engine: “metastatic cervical cancer”, “cervical cancer epigenetics”, “cervical cancer genetics”, “cervical cancer mirnas”, “cervical cancer lncrnas”, “cervical cancer clinical trials” and “metastatic cervical cancer hpv”, in combination with boolean connectors ‘AND’ and ‘OR’. A total of 114 articles were reviewed, published between 1989 and 2022. Results and conclusions: It is essential to understand and know the epigenetic mechanisms associated with the cervical cancer pathogenesis and progression, to create new targeted treatment schemes for metastatic cervical cancer to reduce the mortality rate and increase disease-free survival. https://bccr.tums.ac.ir/index.php/bccrj/article/view/499metastasiscervical cancerlncRNAclinical trialstargeted therapy |
| spellingShingle | Josué Mondragón-Morales Rogelio Rogel-Alvarado Iris Alejandra Noverón-Figueroa Max Morales-Gutiérrez Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma Basic & Clinical Cancer Research metastasis cervical cancer lncRNA clinical trials targeted therapy |
| title | Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma |
| title_full | Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma |
| title_fullStr | Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma |
| title_full_unstemmed | Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma |
| title_short | Epigenetic mechanisms associated with progression, prognosis, and new treatment strategies for metastatic cervical squamous cell carcinoma |
| title_sort | epigenetic mechanisms associated with progression prognosis and new treatment strategies for metastatic cervical squamous cell carcinoma |
| topic | metastasis cervical cancer lncRNA clinical trials targeted therapy |
| url | https://bccr.tums.ac.ir/index.php/bccrj/article/view/499 |
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