Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria.
In immunocompromised individuals, Cytomegalovirus (CMV) primary infection, reactivation and reinfection cause severe disease with a high case of fatality unless diagnosed and treated appropriately at an early stage. A synergistic effect may worsen the immunological profile and could potentially tran...
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| Format: | Article |
| Language: | English |
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Hammer Head Production Limited
2017-06-01
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| Series: | Sokoto Journal of Medical Laboratory Science |
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| Online Access: | https://sokjmls.com.ng/index.php/SJMLS/article/view/352 |
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| author | Omosigho Omoruyi Pius*, Eghafona Nosakhare Odeh, Okojie Racheal Obhade |
| author_facet | Omosigho Omoruyi Pius*, Eghafona Nosakhare Odeh, Okojie Racheal Obhade |
| author_sort | Omosigho Omoruyi Pius*, Eghafona Nosakhare Odeh, Okojie Racheal Obhade |
| collection | DOAJ |
| description | In immunocompromised individuals, Cytomegalovirus (CMV) primary infection, reactivation and reinfection cause severe disease with a high case of fatality unless diagnosed and treated appropriately at an early stage. A synergistic effect may worsen the immunological profile and could potentially translate into a more rapid disease progression in HIV infection. This study was conducted to determine the prevalence of cytomegalovirus co-infection, evaluate the immunological outcome and risk factors of primary CMV infection among HIV positive patients in Federal Medical Centre Bida. Blood samples was collected for CMV IgG and IgM ELISA testing of three hundred and eighty- five (385) HIV positive patients on HAART. CD4+ cell counts were estimated using a new model Partec Cyflow counter. Out of the three hundred and eighty-five (385) HIV positive subjects, an overall distribution of 84.2% IgG and 19.8% IgM CMV were found among patients with HIV in Bida. CD4+ count <200cell/µl was a risk factor for acquiring primary CMV infection however, patients with moderate and high CD4+ count (>200 to 1000 cells/ µl) were susceptible and had high chances of developing reactivation of CMV infection in HIV /AIDS. There was no significant difference between CMV primary infection and CD4+ count (p>0.05). Previous history of blood transfusion was a risk factor for CMV infection among HIV patients in Bida. |
| format | Article |
| id | doaj-art-d8198f1e36024d4a8ffe2c9c86634ab8 |
| institution | Kabale University |
| issn | 2536-7153 |
| language | English |
| publishDate | 2017-06-01 |
| publisher | Hammer Head Production Limited |
| record_format | Article |
| series | Sokoto Journal of Medical Laboratory Science |
| spelling | doaj-art-d8198f1e36024d4a8ffe2c9c86634ab82025-08-20T03:41:46ZengHammer Head Production LimitedSokoto Journal of Medical Laboratory Science2536-71532017-06-0122352Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria.Omosigho Omoruyi Pius*, Eghafona Nosakhare Odeh, Okojie Racheal ObhadeIn immunocompromised individuals, Cytomegalovirus (CMV) primary infection, reactivation and reinfection cause severe disease with a high case of fatality unless diagnosed and treated appropriately at an early stage. A synergistic effect may worsen the immunological profile and could potentially translate into a more rapid disease progression in HIV infection. This study was conducted to determine the prevalence of cytomegalovirus co-infection, evaluate the immunological outcome and risk factors of primary CMV infection among HIV positive patients in Federal Medical Centre Bida. Blood samples was collected for CMV IgG and IgM ELISA testing of three hundred and eighty- five (385) HIV positive patients on HAART. CD4+ cell counts were estimated using a new model Partec Cyflow counter. Out of the three hundred and eighty-five (385) HIV positive subjects, an overall distribution of 84.2% IgG and 19.8% IgM CMV were found among patients with HIV in Bida. CD4+ count <200cell/µl was a risk factor for acquiring primary CMV infection however, patients with moderate and high CD4+ count (>200 to 1000 cells/ µl) were susceptible and had high chances of developing reactivation of CMV infection in HIV /AIDS. There was no significant difference between CMV primary infection and CD4+ count (p>0.05). Previous history of blood transfusion was a risk factor for CMV infection among HIV patients in Bida.https://sokjmls.com.ng/index.php/SJMLS/article/view/352cmv, hiv, cd4+, blood transfusion, bida. |
| spellingShingle | Omosigho Omoruyi Pius*, Eghafona Nosakhare Odeh, Okojie Racheal Obhade Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. Sokoto Journal of Medical Laboratory Science cmv, hiv, cd4+, blood transfusion, bida. |
| title | Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. |
| title_full | Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. |
| title_fullStr | Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. |
| title_full_unstemmed | Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. |
| title_short | Cytomegalovirus Co-infection among Human Immunodeficiency Virus (HIV) Positive Patients in Bida, Niger State, Nigeria. |
| title_sort | cytomegalovirus co infection among human immunodeficiency virus hiv positive patients in bida niger state nigeria |
| topic | cmv, hiv, cd4+, blood transfusion, bida. |
| url | https://sokjmls.com.ng/index.php/SJMLS/article/view/352 |
| work_keys_str_mv | AT omosighoomoruyipiuseghafonanosakhareodehokojierachealobhade cytomegaloviruscoinfectionamonghumanimmunodeficiencyvirushivpositivepatientsinbidanigerstatenigeria |