Multivalent fusion protein targeting VEGFR2 and DR5 receptors: assessing the antiangiogenic and antitumor effects via multimodal microangiography

Multivalent fusion protein targeting VEGFR2 and DR5 receptors: assessing the antiangiogenic and antitumor effects via multimodal microangiography

Abstract Background Anti-angiogenic therapy is a clinically validated method for cancer treatment. It was previously revealed that concurrent targeting of angiogenic and death receptor signaling pathways by a multivalent DR5-specific cytokine TRAIL variant DR5-B genetically fused with the effector p...

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Main Authors: Irina N. Druzhkova, Anna G. Orlova, Anastasiia S. Fedulova, Arina V. Avakiants, Alina A. Isakova, Ekaterina V. Kukovyakina, Yuan Zijian, Ekaterina A. Plotnikova, Galina V. Trunova, Andrey A. Pankratov, Anton A. Plekhanov, Alexey A. Kurnikov, Pavel V. Subochev, Alexey K. Shaytan, Marine E. Gasparian, Mikhail P. Kirpichnikov, Dmitry A. Dolgikh, Daniel Razansky, Anne V. Yagolovich
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Journal of Translational Medicine
Subjects:
VEGFR2
TRAIL
Anti-angiogenic
Molecular modeling
Optoacoustic imaging
Optical coherence tomography
Online Access:https://doi.org/10.1186/s12967-025-06859-8
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