Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon
<i>Plasmodium malariae</i> is a neglected human malaria parasite despite its global distribution and propensity for persistent, sub-microscopic infections, which are associated with a mild but significant disease burden. Artemisinin-based therapies appear to be efficacious, but the susce...
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2025-05-01
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| author | Yudi T. Pinilla Anton Hoffmann Maxim Viehweg Nathanaël Saison Stravensky Terence Boussougou Sambe Ange Gatien Doumba Ndalembouly Barclaye Ngossanga Florence Awamu Ayola Akim Adegnika Steffen Borrmann |
| author_facet | Yudi T. Pinilla Anton Hoffmann Maxim Viehweg Nathanaël Saison Stravensky Terence Boussougou Sambe Ange Gatien Doumba Ndalembouly Barclaye Ngossanga Florence Awamu Ayola Akim Adegnika Steffen Borrmann |
| author_sort | Yudi T. Pinilla |
| collection | DOAJ |
| description | <i>Plasmodium malariae</i> is a neglected human malaria parasite despite its global distribution and propensity for persistent, sub-microscopic infections, which are associated with a mild but significant disease burden. Artemisinin-based therapies appear to be efficacious, but the susceptibility profiles of field isolates are largely unknown. We performed ex vivo assays with isolates collected from asymptomatic volunteers in Gabon. The mean concentrations required to inhibit 50% of growth (IC50) with chloroquine (n = 21), artesunate (n = 20), atovaquone (n = 21), and lumefantrine (n = 14) were 7.2 nM, 2.7 nM, 3.1 nM, and 7.4 nM, respectively. Our study provides novel data on the ex vivo susceptibility of <i>P. malariae</i> to several key antimalarials, including the first dataset for atovaquone. |
| format | Article |
| id | doaj-art-d8133eea9ede4d2f951c3d2dca660cc4 |
| institution | Kabale University |
| issn | 2076-0817 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Pathogens |
| spelling | doaj-art-d8133eea9ede4d2f951c3d2dca660cc42025-08-20T03:48:02ZengMDPI AGPathogens2076-08172025-05-0114545310.3390/pathogens14050453Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in GabonYudi T. Pinilla0Anton Hoffmann1Maxim Viehweg2Nathanaël Saison3Stravensky Terence Boussougou Sambe4Ange Gatien Doumba Ndalembouly5Barclaye Ngossanga6Florence Awamu7Ayola Akim Adegnika8Steffen Borrmann9Centre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, GabonCentre de Recherches Médicales de Lambaréné, Lambaréné BP 242, Gabon<i>Plasmodium malariae</i> is a neglected human malaria parasite despite its global distribution and propensity for persistent, sub-microscopic infections, which are associated with a mild but significant disease burden. Artemisinin-based therapies appear to be efficacious, but the susceptibility profiles of field isolates are largely unknown. We performed ex vivo assays with isolates collected from asymptomatic volunteers in Gabon. The mean concentrations required to inhibit 50% of growth (IC50) with chloroquine (n = 21), artesunate (n = 20), atovaquone (n = 21), and lumefantrine (n = 14) were 7.2 nM, 2.7 nM, 3.1 nM, and 7.4 nM, respectively. Our study provides novel data on the ex vivo susceptibility of <i>P. malariae</i> to several key antimalarials, including the first dataset for atovaquone.https://www.mdpi.com/2076-0817/14/5/453<i>P. malariae</i>drug susceptibility assaymalariaGabon |
| spellingShingle | Yudi T. Pinilla Anton Hoffmann Maxim Viehweg Nathanaël Saison Stravensky Terence Boussougou Sambe Ange Gatien Doumba Ndalembouly Barclaye Ngossanga Florence Awamu Ayola Akim Adegnika Steffen Borrmann Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon Pathogens <i>P. malariae</i> drug susceptibility assay malaria Gabon |
| title | Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon |
| title_full | Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon |
| title_fullStr | Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon |
| title_full_unstemmed | Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon |
| title_short | Ex Vivo Drug Susceptibility of <i>Plasmodium malariae</i> Isolates to Antimalarial Drugs in Gabon |
| title_sort | ex vivo drug susceptibility of i plasmodium malariae i isolates to antimalarial drugs in gabon |
| topic | <i>P. malariae</i> drug susceptibility assay malaria Gabon |
| url | https://www.mdpi.com/2076-0817/14/5/453 |
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