A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression
Post-ICU Syndromes (PICS) remain a devastating problem for intensive care unit (ICU) survivors. It is currently unknown if de novo initiation of an antidepressant medication during ICU stay decreases the prevalence of post-ICU depression. We performed a retrospective, pilot study evaluating patients...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Critical Care Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2017/5804860 |
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| author | Daniel Haines Johanna Hild Jianghua He Lucy Stun Angie Ballew Justin L. Green Lewis Satterwhite Brigid C. Flynn |
| author_facet | Daniel Haines Johanna Hild Jianghua He Lucy Stun Angie Ballew Justin L. Green Lewis Satterwhite Brigid C. Flynn |
| author_sort | Daniel Haines |
| collection | DOAJ |
| description | Post-ICU Syndromes (PICS) remain a devastating problem for intensive care unit (ICU) survivors. It is currently unknown if de novo initiation of an antidepressant medication during ICU stay decreases the prevalence of post-ICU depression. We performed a retrospective, pilot study evaluating patients who had not previously been on an antidepressant medication and who were started on an antidepressant while in the trauma surgical, cardiothoracic, or medical intensive care unit (ICU). The PHQ-2 depression scale was used to ascertain the presence of depression after ICU discharge and compared this to historical controls. Of 2,988 patients admitted to the ICU, 69 patients had de novo initiation of an antidepressant medication and 27 patients were alive and available for study inclusion. We found the prevalence of depression in these patients to be 26%, which is not statistically different than the prevalence of post-ICU depression in historical controls [95% CI (27.6%, 51.6%)]. De novo initiation of an antidepressant medication did not substantially decrease the prevalence of post-ICU depression in this retrospective, pilot study. |
| format | Article |
| id | doaj-art-d8121f1c9ebf495bb5a4a26b2c8bc9a4 |
| institution | Kabale University |
| issn | 2090-1305 2090-1313 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Critical Care Research and Practice |
| spelling | doaj-art-d8121f1c9ebf495bb5a4a26b2c8bc9a42025-08-20T03:24:36ZengWileyCritical Care Research and Practice2090-13052090-13132017-01-01201710.1155/2017/58048605804860A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU DepressionDaniel Haines0Johanna Hild1Jianghua He2Lucy Stun3Angie Ballew4Justin L. Green5Lewis Satterwhite6Brigid C. Flynn7Department of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USADepartment of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USADepartment of Biostatistics, University of Kansas Hospital, Kansas City, KS, USADepartment of Pharmacy, University of Kansas Hospital, Kansas City, KS, USADepartment of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USADepartment of Surgery, University of Kansas Hospital, Kansas City, KS, USADepartment of Medicine, University of Kansas Hospital, Kansas City, KS, USADepartment of Anesthesiology, University of Kansas Hospital, Kansas City, KS, USAPost-ICU Syndromes (PICS) remain a devastating problem for intensive care unit (ICU) survivors. It is currently unknown if de novo initiation of an antidepressant medication during ICU stay decreases the prevalence of post-ICU depression. We performed a retrospective, pilot study evaluating patients who had not previously been on an antidepressant medication and who were started on an antidepressant while in the trauma surgical, cardiothoracic, or medical intensive care unit (ICU). The PHQ-2 depression scale was used to ascertain the presence of depression after ICU discharge and compared this to historical controls. Of 2,988 patients admitted to the ICU, 69 patients had de novo initiation of an antidepressant medication and 27 patients were alive and available for study inclusion. We found the prevalence of depression in these patients to be 26%, which is not statistically different than the prevalence of post-ICU depression in historical controls [95% CI (27.6%, 51.6%)]. De novo initiation of an antidepressant medication did not substantially decrease the prevalence of post-ICU depression in this retrospective, pilot study.http://dx.doi.org/10.1155/2017/5804860 |
| spellingShingle | Daniel Haines Johanna Hild Jianghua He Lucy Stun Angie Ballew Justin L. Green Lewis Satterwhite Brigid C. Flynn A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression Critical Care Research and Practice |
| title | A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression |
| title_full | A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression |
| title_fullStr | A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression |
| title_full_unstemmed | A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression |
| title_short | A Retrospective, Pilot Study of De Novo Antidepressant Medication Initiation in Intensive Care Unit Patients and Post-ICU Depression |
| title_sort | retrospective pilot study of de novo antidepressant medication initiation in intensive care unit patients and post icu depression |
| url | http://dx.doi.org/10.1155/2017/5804860 |
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