Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy

Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated u...

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Main Authors: Peace Mayen Edwin Ubulom, Chinweizu Ejikeme Udobi, Mark Iheukwumere Madu
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Journal of Tropical Medicine
Online Access:http://dx.doi.org/10.1155/2015/947390
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author Peace Mayen Edwin Ubulom
Chinweizu Ejikeme Udobi
Mark Iheukwumere Madu
author_facet Peace Mayen Edwin Ubulom
Chinweizu Ejikeme Udobi
Mark Iheukwumere Madu
author_sort Peace Mayen Edwin Ubulom
collection DOAJ
description Objective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. The combination of 7.5 mg/kg of Amodiaquine and 12.8 mg/kg of Ciprofloxacin, however, showed the most significant antiplasmodial effect of the doses used reducing the number of parasites per 100 RBC from 60 to 10 (83.33%). Conclusions. Appropriate Amodiaquine and Ciprofloxacin combination will be effective for the treatment of malaria and better than either Amodiaquine or Ciprofloxacin singly at their recommended dosage levels.
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spelling doaj-art-d809b1a5caf4440d97ed0e0a0bb0ba4f2025-02-03T05:45:23ZengWileyJournal of Tropical Medicine1687-96861687-96942015-01-01201510.1155/2015/947390947390Amodiaquine and Ciprofloxacin Combination in Plasmodiasis TherapyPeace Mayen Edwin Ubulom0Chinweizu Ejikeme Udobi1Mark Iheukwumere Madu2Pharmaceutical Microbiology and Parasitology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom, NigeriaPharmaceutical Microbiology and Parasitology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom, NigeriaPharmaceutical Microbiology and Parasitology Unit, Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmacy, University of Uyo, Uyo, Akwa Ibom, NigeriaObjective. The study was designed to determine the efficacy of combined Amodiaquine and Ciprofloxacin in plasmodiasis therapy. Method. The in vivo antiplasmodial effect of different dosage levels of Amodiaquine, Ciprofloxacin, and their combinations against Plasmodium berghei berghei was evaluated using Swiss albino mice. Results. Amodiaquine (a known antiplasmodial agent) had a fairly significant antiplasmodial effect reducing the parasites for every 100 red blood cells (RBC) from 66 to 16 (75.75%) at the tolerable dosage level of 7.5 mg/kg body weight while Ciprofloxacin (an antibiotic known to have antimalarial effect) showed an insignificant antiplasmodial effect reducing the parasites for every 100 RBC from 65 to 64 (1.53%) at the tolerable dosage level of 10.7 mg/kg body weight. Conversely, the combination therapy of Amodiaquine and Ciprofloxacin had a significant antiplasmodial effect at all the doses administered. The combination of 7.5 mg/kg of Amodiaquine and 12.8 mg/kg of Ciprofloxacin, however, showed the most significant antiplasmodial effect of the doses used reducing the number of parasites per 100 RBC from 60 to 10 (83.33%). Conclusions. Appropriate Amodiaquine and Ciprofloxacin combination will be effective for the treatment of malaria and better than either Amodiaquine or Ciprofloxacin singly at their recommended dosage levels.http://dx.doi.org/10.1155/2015/947390
spellingShingle Peace Mayen Edwin Ubulom
Chinweizu Ejikeme Udobi
Mark Iheukwumere Madu
Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
Journal of Tropical Medicine
title Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
title_full Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
title_fullStr Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
title_full_unstemmed Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
title_short Amodiaquine and Ciprofloxacin Combination in Plasmodiasis Therapy
title_sort amodiaquine and ciprofloxacin combination in plasmodiasis therapy
url http://dx.doi.org/10.1155/2015/947390
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