CASSH Registry: Rationale and Study Design
Background Carotid artery disease, a major cause of strokes, often results from carotid atherosclerotic stenosis. Although carotid endarterectomy has long been the standard treatment, carotid artery stenting (CAS) emerged as an alternative for high‐risk surgical patients. Operator experience plays a...
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| Format: | Article |
| Language: | English |
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Wiley
2024-11-01
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| Series: | Stroke: Vascular and Interventional Neurology |
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| Online Access: | https://www.ahajournals.org/doi/10.1161/SVIN.124.001455 |
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| author | Mohamad Ezzeldin Ali Kerro Ameer E. Hassan Muhammad Shazam Hussain Suhas V. V. Tatapudi Rime Ezzeldin Faheem G. Sheriff Peter Kan Chizoba Ezepue Kaiz S. Asif Ramesh Grandhi Ali Alaraj Muhammad Niazi Saif Bushnaq Omar Tanweer Kaustubh Limaye Tunmi Anwoju Zuhair Ali Osama O. Zaidat Farhan Siddiq |
| author_facet | Mohamad Ezzeldin Ali Kerro Ameer E. Hassan Muhammad Shazam Hussain Suhas V. V. Tatapudi Rime Ezzeldin Faheem G. Sheriff Peter Kan Chizoba Ezepue Kaiz S. Asif Ramesh Grandhi Ali Alaraj Muhammad Niazi Saif Bushnaq Omar Tanweer Kaustubh Limaye Tunmi Anwoju Zuhair Ali Osama O. Zaidat Farhan Siddiq |
| author_sort | Mohamad Ezzeldin |
| collection | DOAJ |
| description | Background Carotid artery disease, a major cause of strokes, often results from carotid atherosclerotic stenosis. Although carotid endarterectomy has long been the standard treatment, carotid artery stenting (CAS) emerged as an alternative for high‐risk surgical patients. Operator experience plays a crucial role in reducing complications, with neurointerventional specialists demonstrating proficiency in CAS. However, they are often underrepresented in CAS studies. The CASSH (Carotid Artery Stenting Outcomes in Comprehensive Stroke Hospitals) registry aims to provide comprehensive insights into CAS outcomes, particularly when performed by neurointerventionalists at comprehensive stroke centers. Methods The CASSH is a multicenter, prospective, observational study currently enrolling patients with carotid artery stenosis undergoing CAS performed by neurointerventional physicians. All the participating sites will screen and report cases that meet inclusion criteria, on a monthly basis. The decision of whether to use CAS is at the discretion of the interventionalist. Results We will collect patients’ baseline clinical, demographic, and radiographic data. In addition, we plan to collect procedure variables and postoperative clinical and imaging data. Outcomes include the rate of postoperative symptomatic stroke (hemorrhagic/ischemic), access site complications, in‐stent thrombosis, and mortality. Conclusion Current literature underrepresents neurointerventionalists in CAS studies, especially as it pertains to procedural expertise and outcomes. CASSH is a prospective observational study that will enhance our understanding of CAS management and outcomes, emphasizing the benefits of neurointerventional expertise within comprehensive stroke centers. |
| format | Article |
| id | doaj-art-d806f80a71fa446e9d1e35d839f7f5ca |
| institution | Kabale University |
| issn | 2694-5746 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Stroke: Vascular and Interventional Neurology |
| spelling | doaj-art-d806f80a71fa446e9d1e35d839f7f5ca2025-08-20T03:24:48ZengWileyStroke: Vascular and Interventional Neurology2694-57462024-11-014610.1161/SVIN.124.001455CASSH Registry: Rationale and Study DesignMohamad Ezzeldin0Ali Kerro1Ameer E. Hassan2Muhammad Shazam Hussain3Suhas V. V. Tatapudi4Rime Ezzeldin5Faheem G. Sheriff6Peter Kan7Chizoba Ezepue8Kaiz S. Asif9Ramesh Grandhi10Ali Alaraj11Muhammad Niazi12Saif Bushnaq13Omar Tanweer14Kaustubh Limaye15Tunmi Anwoju16Zuhair Ali17Osama O. Zaidat18Farhan Siddiq19Department of Neuroendovascular Surgery HCA Houston Healthcare Kingwood Kingwood TXDepartment of Neurology HCA Houston Healthcare Conroe Conroe TXDepartment of Neurology Valley Baptist Medical Center Brownsville TXDepartment of Neurology Cleveland Clinic Cleveland OHDepartment of Internal Medicine HCA Houston Kingwood/University of Houston College of Medicine Kingwood TXMedicine Jordan University of Science and Technology Irbid JordanDepartment of Neurology Texas Tech University Health Sciences Center El Paso TXDepartment of Neurosurgery University of Texas Medical Branch Galveston TXDepartment of Neurology SSM Health Saint Louis University Hospital St. Louis MODepartment of Neurology Ascension Health and University of Illinois Chicago Chicago ILDepartment of Neurosurgery University of Utah Salt Lake City UTDepartment of Neurosurgery University of Illinois Chicago Chicago ILDepartment of Neurology WellSpan Health York PADepartment of Neurology Texas Tech University Lubbock TXDepartment of Neurosurgery Baylor St. Luke Medical Center Houston TXDepartment of Neurology Neurological Surgery and Radiology Indiana University School of Medicine IndianapolisDepartment of Clinical Sciences HCA Houston Healthcare Kingwood Kingwood TXDepartment of Clinical Sciences HCA Houston Healthcare Kingwood Kingwood TXDepartment of Neurology St. Vincent Medical Center Toledo OHDepartment of Neurosurgery University Hospital Missouri Columbia MOBackground Carotid artery disease, a major cause of strokes, often results from carotid atherosclerotic stenosis. Although carotid endarterectomy has long been the standard treatment, carotid artery stenting (CAS) emerged as an alternative for high‐risk surgical patients. Operator experience plays a crucial role in reducing complications, with neurointerventional specialists demonstrating proficiency in CAS. However, they are often underrepresented in CAS studies. The CASSH (Carotid Artery Stenting Outcomes in Comprehensive Stroke Hospitals) registry aims to provide comprehensive insights into CAS outcomes, particularly when performed by neurointerventionalists at comprehensive stroke centers. Methods The CASSH is a multicenter, prospective, observational study currently enrolling patients with carotid artery stenosis undergoing CAS performed by neurointerventional physicians. All the participating sites will screen and report cases that meet inclusion criteria, on a monthly basis. The decision of whether to use CAS is at the discretion of the interventionalist. Results We will collect patients’ baseline clinical, demographic, and radiographic data. In addition, we plan to collect procedure variables and postoperative clinical and imaging data. Outcomes include the rate of postoperative symptomatic stroke (hemorrhagic/ischemic), access site complications, in‐stent thrombosis, and mortality. Conclusion Current literature underrepresents neurointerventionalists in CAS studies, especially as it pertains to procedural expertise and outcomes. CASSH is a prospective observational study that will enhance our understanding of CAS management and outcomes, emphasizing the benefits of neurointerventional expertise within comprehensive stroke centers.https://www.ahajournals.org/doi/10.1161/SVIN.124.001455carotid artery stenosiscarotid artery stentingcomprehensive stroke centerneuro interventional surgeon |
| spellingShingle | Mohamad Ezzeldin Ali Kerro Ameer E. Hassan Muhammad Shazam Hussain Suhas V. V. Tatapudi Rime Ezzeldin Faheem G. Sheriff Peter Kan Chizoba Ezepue Kaiz S. Asif Ramesh Grandhi Ali Alaraj Muhammad Niazi Saif Bushnaq Omar Tanweer Kaustubh Limaye Tunmi Anwoju Zuhair Ali Osama O. Zaidat Farhan Siddiq CASSH Registry: Rationale and Study Design Stroke: Vascular and Interventional Neurology carotid artery stenosis carotid artery stenting comprehensive stroke center neuro interventional surgeon |
| title | CASSH Registry: Rationale and Study Design |
| title_full | CASSH Registry: Rationale and Study Design |
| title_fullStr | CASSH Registry: Rationale and Study Design |
| title_full_unstemmed | CASSH Registry: Rationale and Study Design |
| title_short | CASSH Registry: Rationale and Study Design |
| title_sort | cassh registry rationale and study design |
| topic | carotid artery stenosis carotid artery stenting comprehensive stroke center neuro interventional surgeon |
| url | https://www.ahajournals.org/doi/10.1161/SVIN.124.001455 |
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