Efficacy of LaAg Vaccine Associated with Saponin Against <i>Leishmania amazonensis</i> Infection

Efficacy of LaAg Vaccine Associated with Saponin Against <i>Leishmania amazonensis</i> Infection

Background/Objectives: The total lysate of <i>Leishmania amazonensis</i> (LaAg) is one of the most extensively studied vaccine formulations against leishmaniasis. Despite demonstrating safety and immunogenicity when administered intramuscularly, LaAg has failed to show efficacy in clinic...

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Main Authors: Mirian França de Mello, Patrícia de Almeida Machado, Pollyanna Stephanie Gomes, Gabriel Oliveira-Silva, Monique Pacheco Duarte Carneiro, Tadeu Diniz Ramos, Juliana Elena Silveira Pratti, Raquel Peralva, Luan Firmino-Cruz, Alda Maria Da-Cruz, Luciana Covre, Daniel Claúdio Oliveira Gomes, Bartira Rossi-Bergmann, Eduardo Fonseca Pinto, Alessandra Marcia da Fonseca-Martins, Herbert Leonel de Matos Guedes
Format: Article
Language:English
Published: MDPI AG 2025-01-01
Series:Vaccines
Subjects:
vaccine
<i>Leishmania</i>
saponin
Online Access:https://www.mdpi.com/2076-393X/13/2/129
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