Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review
Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case repor...
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| Format: | Article |
| Language: | English |
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Wiley
2019-01-01
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| Series: | Case Reports in Hematology |
| Online Access: | http://dx.doi.org/10.1155/2019/3540487 |
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| _version_ | 1849683425701658624 |
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| author | Sharad Khurana Manuel Beltran Liuyan Jiang Ernesto Ayala Vivek Roy |
| author_facet | Sharad Khurana Manuel Beltran Liuyan Jiang Ernesto Ayala Vivek Roy |
| author_sort | Sharad Khurana |
| collection | DOAJ |
| description | Cutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. We discuss here another patient diagnosed with primary cutaneous T-cell LBL at our institute. This patient was initially misdiagnosed as having peripheral T-cell lymphoma NOS. Cytogenetic analysis showed the CDKN2A deletion (−9p21×2) in addition to three intact copies of ABL1 (+9q34). Although she failed multiple lines of intensive chemotherapy, her disease remained confined to the skin. We believe that this presentation of T-LBL is underreported, and many patients are likely misdiagnosed as having high-grade cutaneous T-cell lymphomas. With this case and literature review, we would like to highlight the importance of keeping lymphoblastic lymphoma on the differential diagnosis of cutaneous T-cell lymphoma-like lesions to avoid delay in diagnosis and inappropriate treatment of this aggressive disease. |
| format | Article |
| id | doaj-art-d8022ef67fbc43108ca71a8410175da9 |
| institution | DOAJ |
| issn | 2090-6560 2090-6579 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Case Reports in Hematology |
| spelling | doaj-art-d8022ef67fbc43108ca71a8410175da92025-08-20T03:23:52ZengWileyCase Reports in Hematology2090-65602090-65792019-01-01201910.1155/2019/35404873540487Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature ReviewSharad Khurana0Manuel Beltran1Liuyan Jiang2Ernesto Ayala3Vivek Roy4Mayo Clinic, Jacksonville, FL, USAMayo Clinic, Jacksonville, FL, USAMayo Clinic, Jacksonville, FL, USAMayo Clinic, Jacksonville, FL, USAMayo Clinic, Jacksonville, FL, USACutaneous involvement by precursor T-cell lymphoblastic leukemia/lymphoma (T-ALL/LBL) is rare, and almost all cases are seen in association with bone marrow, blood, and/or lymph node involvement. Presentation with isolated skin involvement is very rare. Literature review revealed only one case report of primary cutaneous T-cell LBL. We discuss here another patient diagnosed with primary cutaneous T-cell LBL at our institute. This patient was initially misdiagnosed as having peripheral T-cell lymphoma NOS. Cytogenetic analysis showed the CDKN2A deletion (−9p21×2) in addition to three intact copies of ABL1 (+9q34). Although she failed multiple lines of intensive chemotherapy, her disease remained confined to the skin. We believe that this presentation of T-LBL is underreported, and many patients are likely misdiagnosed as having high-grade cutaneous T-cell lymphomas. With this case and literature review, we would like to highlight the importance of keeping lymphoblastic lymphoma on the differential diagnosis of cutaneous T-cell lymphoma-like lesions to avoid delay in diagnosis and inappropriate treatment of this aggressive disease.http://dx.doi.org/10.1155/2019/3540487 |
| spellingShingle | Sharad Khurana Manuel Beltran Liuyan Jiang Ernesto Ayala Vivek Roy Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review Case Reports in Hematology |
| title | Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review |
| title_full | Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review |
| title_fullStr | Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review |
| title_full_unstemmed | Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review |
| title_short | Primary Cutaneous T-Cell Lymphoblastic Lymphoma: Case Report and Literature Review |
| title_sort | primary cutaneous t cell lymphoblastic lymphoma case report and literature review |
| url | http://dx.doi.org/10.1155/2019/3540487 |
| work_keys_str_mv | AT sharadkhurana primarycutaneoustcelllymphoblasticlymphomacasereportandliteraturereview AT manuelbeltran primarycutaneoustcelllymphoblasticlymphomacasereportandliteraturereview AT liuyanjiang primarycutaneoustcelllymphoblasticlymphomacasereportandliteraturereview AT ernestoayala primarycutaneoustcelllymphoblasticlymphomacasereportandliteraturereview AT vivekroy primarycutaneoustcelllymphoblasticlymphomacasereportandliteraturereview |