Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004
Background and objectivesErectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health of men and their partners. Metabolic syndrome (MetS) is the most important public health problem threatening men’s health worldwide, and its current prevalence co...
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Frontiers Media S.A.
2025-03-01
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1543668/full |
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| author | Wei Wang Wei Wang Shuai Zhao Ran Zhou Ran Zhou Pei-Ze Yu Pei-Ze Yu Si-Yuan Pan Si-Yuan Pan Peng-Fei Huan Zhen-Duo Shi Ying Liu Xiao Hu Jing-Ru Lu Conghui Han |
| author_facet | Wei Wang Wei Wang Shuai Zhao Ran Zhou Ran Zhou Pei-Ze Yu Pei-Ze Yu Si-Yuan Pan Si-Yuan Pan Peng-Fei Huan Zhen-Duo Shi Ying Liu Xiao Hu Jing-Ru Lu Conghui Han |
| author_sort | Wei Wang |
| collection | DOAJ |
| description | Background and objectivesErectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health of men and their partners. Metabolic syndrome (MetS) is the most important public health problem threatening men’s health worldwide, and its current prevalence continues to grow. This study examines the relationship between metabolic syndrome and erectile dysfunction (ED).MethodWe conducted a cross-sectional study with data were sourced from NHANES 2001–2004. In this study, the relationship between METS-VF and ED was analyzed using multivariate logistic regression, followed by subgroup analyses to identify sensitive populations. Comparative logistic regression of the Receiver Operating Characteristic (ROC) curve assessed the diagnostic capability of METS-VF against the classical obesity index for ED. Creating Predictive Histograms for ED Patients and assess the net benefit of the model through Decision Curve Analysis (DCA).ResultsThe study enrolled 1,374 participants, of whom 545 self-reported ED history. There was a significant positive association between metabolic syndrome and erectile dysfunction (ED). The risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome (dominance ratio = 2.32, 95% confidence interval: 1.83–2.96, p < 0.001). Subgroup analysis highlighted a stronger correlation in participants aged 50–85 years, hypertensive individuals, and those with large belly circumference. A histogram model including three variables: metabolic syndrome, age and smoking status was constructed to predict the probability of ED occurrence. And decision curve analysis (DCA) was used to assess the net benefit of its nomogram model at different high-risk thresholds. The high clinical utility of the model under different thresholds was illustrated.ConclusionThe risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome. Furthermore, this observed positive correlation emphasizes the need for increased vigilance in patients with advanced age, smoking, and MetS. |
| format | Article |
| id | doaj-art-d7fbe8def00749749dc3349e7e43a974 |
| institution | DOAJ |
| issn | 2296-2565 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Public Health |
| spelling | doaj-art-d7fbe8def00749749dc3349e7e43a9742025-08-20T02:56:36ZengFrontiers Media S.A.Frontiers in Public Health2296-25652025-03-011310.3389/fpubh.2025.15436681543668Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004Wei Wang0Wei Wang1Shuai Zhao2Ran Zhou3Ran Zhou4Pei-Ze Yu5Pei-Ze Yu6Si-Yuan Pan7Si-Yuan Pan8Peng-Fei Huan9Zhen-Duo Shi10Ying Liu11Xiao Hu12Jing-Ru Lu13Conghui Han14School of Medicine, Southeast University, Nanjing, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Urology, ZiBo 148 Hospital, China RongTong Medical Healthcare Group Co. Ltd., Zibo, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaSchool of Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaSchool of Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaSchool of Medicine, Xuzhou Medical University, Xuzhou, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Urology, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Central Laboratory, Xuzhou Central Hospital, Xuzhou, ChinaDepartment of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, ChinaSchool of Medicine, Southeast University, Nanjing, ChinaBackground and objectivesErectile dysfunction is a common clinical condition that seriously affects the quality of life and mental health of men and their partners. Metabolic syndrome (MetS) is the most important public health problem threatening men’s health worldwide, and its current prevalence continues to grow. This study examines the relationship between metabolic syndrome and erectile dysfunction (ED).MethodWe conducted a cross-sectional study with data were sourced from NHANES 2001–2004. In this study, the relationship between METS-VF and ED was analyzed using multivariate logistic regression, followed by subgroup analyses to identify sensitive populations. Comparative logistic regression of the Receiver Operating Characteristic (ROC) curve assessed the diagnostic capability of METS-VF against the classical obesity index for ED. Creating Predictive Histograms for ED Patients and assess the net benefit of the model through Decision Curve Analysis (DCA).ResultsThe study enrolled 1,374 participants, of whom 545 self-reported ED history. There was a significant positive association between metabolic syndrome and erectile dysfunction (ED). The risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome (dominance ratio = 2.32, 95% confidence interval: 1.83–2.96, p < 0.001). Subgroup analysis highlighted a stronger correlation in participants aged 50–85 years, hypertensive individuals, and those with large belly circumference. A histogram model including three variables: metabolic syndrome, age and smoking status was constructed to predict the probability of ED occurrence. And decision curve analysis (DCA) was used to assess the net benefit of its nomogram model at different high-risk thresholds. The high clinical utility of the model under different thresholds was illustrated.ConclusionThe risk of ED in people with metabolic syndrome was 2.32 times higher than that in people without metabolic syndrome. Furthermore, this observed positive correlation emphasizes the need for increased vigilance in patients with advanced age, smoking, and MetS.https://www.frontiersin.org/articles/10.3389/fpubh.2025.1543668/fullmetabolic syndromeerectile dysfunctionNHANESprevalencecross-sectional study |
| spellingShingle | Wei Wang Wei Wang Shuai Zhao Ran Zhou Ran Zhou Pei-Ze Yu Pei-Ze Yu Si-Yuan Pan Si-Yuan Pan Peng-Fei Huan Zhen-Duo Shi Ying Liu Xiao Hu Jing-Ru Lu Conghui Han Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 Frontiers in Public Health metabolic syndrome erectile dysfunction NHANES prevalence cross-sectional study |
| title | Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 |
| title_full | Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 |
| title_fullStr | Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 |
| title_full_unstemmed | Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 |
| title_short | Associations between metabolic syndrome and erectile dysfunction: evidence from the NHANES 2001–2004 |
| title_sort | associations between metabolic syndrome and erectile dysfunction evidence from the nhanes 2001 2004 |
| topic | metabolic syndrome erectile dysfunction NHANES prevalence cross-sectional study |
| url | https://www.frontiersin.org/articles/10.3389/fpubh.2025.1543668/full |
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