Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China
Increasing evidence has shown an unusual relationship between hypertension and COVID-19, which may not be as simple as previously thought. The purpose of our study was to determine the association of hypertension with the onset and development of COVID-19. A meta-analysis was performed to summarize...
Saved in:
| Main Authors: | , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2021-01-01
|
| Series: | International Journal of Hypertension |
| Online Access: | http://dx.doi.org/10.1155/2021/6594863 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850167473632968704 |
|---|---|
| author | Bo Li Lu Zeng Nengjun Sun Yunhe Zhao Faming Zhao Hongjun Bian Wei Yi Jing Yang Bin Li Guohai Su |
| author_facet | Bo Li Lu Zeng Nengjun Sun Yunhe Zhao Faming Zhao Hongjun Bian Wei Yi Jing Yang Bin Li Guohai Su |
| author_sort | Bo Li |
| collection | DOAJ |
| description | Increasing evidence has shown an unusual relationship between hypertension and COVID-19, which may not be as simple as previously thought. The purpose of our study was to determine the association of hypertension with the onset and development of COVID-19. A meta-analysis was performed to summarize the prevalence of hypertension in COVID-19 patients, as well as the usage of ACEIs/ARBs. Metaregression analyses were used to evaluate the association of hypertension with disease severity and mortality. PubMed and Google Scholar were searched for relevant studies. A total of 42 studies including 14138 patients were enrolled in the study. The proportion of hypertension in COVID-19 patients in China was 17.7% according to the enrolled studies, while it was 6.0% in a study containing 72314 confirmed cases, which are both much lower than in the general population. All of the data from the 11 provinces in China showed the same tendency. The proportions of hypertension were higher in severe/ICU patients and nonsurvivors than in nonsevere/ICU patients and survivors. The metaregression analyses suggested that both disease severity and risk of death were associated with the incidence of hypertension. A total of 27.6% of COVID-19 patients with hypertension received ACEI/ARB therapy. The proportion of deaths in COVID-19 patients with hypertension treated with ACEIs/ARBs was significantly lower than that in nonuse patients treated with ACEIs/ARBs. In conclusion, hypertension may reduce the infection risk of COVID-19 but increase the risk of developing worse clinical outcomes. The use of ACEIs/ARBs may benefit COVID-19 patients with hypertension. |
| format | Article |
| id | doaj-art-d7f9a1bd455a4d089cd06caff2faa2d2 |
| institution | OA Journals |
| issn | 2090-0392 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Hypertension |
| spelling | doaj-art-d7f9a1bd455a4d089cd06caff2faa2d22025-08-20T02:21:11ZengWileyInternational Journal of Hypertension2090-03922021-01-01202110.1155/2021/6594863Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in ChinaBo Li0Lu Zeng1Nengjun Sun2Yunhe Zhao3Faming Zhao4Hongjun Bian5Wei Yi6Jing Yang7Bin Li8Guohai Su9Department of CardiologyWeifang Medical UniversityDepartment of Medical AdministrationDepartment of CardiologyDepartment of Infectious DiseasesDepartments of Emergency MedicineDepartment of Intelligent Manufacturing TeachingBinzhou Medical UniversityDepartment of CardiologyDepartment of CardiologyIncreasing evidence has shown an unusual relationship between hypertension and COVID-19, which may not be as simple as previously thought. The purpose of our study was to determine the association of hypertension with the onset and development of COVID-19. A meta-analysis was performed to summarize the prevalence of hypertension in COVID-19 patients, as well as the usage of ACEIs/ARBs. Metaregression analyses were used to evaluate the association of hypertension with disease severity and mortality. PubMed and Google Scholar were searched for relevant studies. A total of 42 studies including 14138 patients were enrolled in the study. The proportion of hypertension in COVID-19 patients in China was 17.7% according to the enrolled studies, while it was 6.0% in a study containing 72314 confirmed cases, which are both much lower than in the general population. All of the data from the 11 provinces in China showed the same tendency. The proportions of hypertension were higher in severe/ICU patients and nonsurvivors than in nonsevere/ICU patients and survivors. The metaregression analyses suggested that both disease severity and risk of death were associated with the incidence of hypertension. A total of 27.6% of COVID-19 patients with hypertension received ACEI/ARB therapy. The proportion of deaths in COVID-19 patients with hypertension treated with ACEIs/ARBs was significantly lower than that in nonuse patients treated with ACEIs/ARBs. In conclusion, hypertension may reduce the infection risk of COVID-19 but increase the risk of developing worse clinical outcomes. The use of ACEIs/ARBs may benefit COVID-19 patients with hypertension.http://dx.doi.org/10.1155/2021/6594863 |
| spellingShingle | Bo Li Lu Zeng Nengjun Sun Yunhe Zhao Faming Zhao Hongjun Bian Wei Yi Jing Yang Bin Li Guohai Su Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China International Journal of Hypertension |
| title | Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China |
| title_full | Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China |
| title_fullStr | Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China |
| title_full_unstemmed | Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China |
| title_short | Hypertension May Reduce the Infection Risk but Increase the Severity of COVID-19: Based on the Current Data in China |
| title_sort | hypertension may reduce the infection risk but increase the severity of covid 19 based on the current data in china |
| url | http://dx.doi.org/10.1155/2021/6594863 |
| work_keys_str_mv | AT boli hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT luzeng hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT nengjunsun hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT yunhezhao hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT famingzhao hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT hongjunbian hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT weiyi hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT jingyang hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT binli hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina AT guohaisu hypertensionmayreducetheinfectionriskbutincreasetheseverityofcovid19basedonthecurrentdatainchina |