Lipoprotein profile in girls with asymptomatic hyperuricemia
To investigate the relation between uricemia and lipid profile, 539 Arkhangelsk schoolgirls aged 7-17 were examined. With upper norm limit of 0. 31 mmol/l, the prevalence of asymptomatic chronic hyperuricemia among Arkhangelsk girls was as high as 25 %. With uricemia higher than 0. 31 mmol/l, total...
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«FIRMA «SILICEA» LLC
2004-02-01
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| Series: | Российский кардиологический журнал |
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| Online Access: | https://russjcardiol.elpub.ru/jour/article/view/1857 |
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| author | S. I. Maljavskaya T. A. Toropygina V. E. Tril V. A. Ternovskaya |
| author_facet | S. I. Maljavskaya T. A. Toropygina V. E. Tril V. A. Ternovskaya |
| author_sort | S. I. Maljavskaya |
| collection | DOAJ |
| description | To investigate the relation between uricemia and lipid profile, 539 Arkhangelsk schoolgirls aged 7-17 were examined. With upper norm limit of 0. 31 mmol/l, the prevalence of asymptomatic chronic hyperuricemia among Arkhangelsk girls was as high as 25 %. With uricemia higher than 0. 31 mmol/l, total cholesterol, triglycerides, LDL cholesterol levels were significantly elevated. Mean total cholesterol levels in such individuals were higher than WHO norms of normocholesterolemia for children and adolescents. From the other hand, among individuals with dyslipidemia, uricemia more than 0. 31 mmol/l was diagnosed significantly more frequently. All measured lipid and liporotein parameters directly correlated with uricemia level, and inversely correlated with urate excretion rate, regardless of pathogenetic hyperuricemia mechanisms. Our results point to the fact that chronic hyperuricemia is assosiated with atherogenic lipid/lipoprotein phenotype, observed as early as in childhood, and possibly acts as an indicator of atherosclerosis risk. Therefore, use of a lower norm for population screening seems rational, from position of primary and secondary prevention of atherosclerosis. Our data support detailed examination of lipid metabolism if uricemia is higher than 0. 31 mmol/l. |
| format | Article |
| id | doaj-art-d7f50a5691af451087f87fa5d19f9cb9 |
| institution | Kabale University |
| issn | 1560-4071 2618-7620 |
| language | Russian |
| publishDate | 2004-02-01 |
| publisher | «FIRMA «SILICEA» LLC |
| record_format | Article |
| series | Российский кардиологический журнал |
| spelling | doaj-art-d7f50a5691af451087f87fa5d19f9cb92025-08-20T03:57:26Zrus«FIRMA «SILICEA» LLCРоссийский кардиологический журнал1560-40712618-76202004-02-010133371615Lipoprotein profile in girls with asymptomatic hyperuricemiaS. I. Maljavskaya0T. A. Toropygina1V. E. Tril2V. A. Ternovskaya3Северный государственный медицинский университетСеверный государственный медицинский университетСеверный государственный медицинский университетСеверный государственный медицинский университетTo investigate the relation between uricemia and lipid profile, 539 Arkhangelsk schoolgirls aged 7-17 were examined. With upper norm limit of 0. 31 mmol/l, the prevalence of asymptomatic chronic hyperuricemia among Arkhangelsk girls was as high as 25 %. With uricemia higher than 0. 31 mmol/l, total cholesterol, triglycerides, LDL cholesterol levels were significantly elevated. Mean total cholesterol levels in such individuals were higher than WHO norms of normocholesterolemia for children and adolescents. From the other hand, among individuals with dyslipidemia, uricemia more than 0. 31 mmol/l was diagnosed significantly more frequently. All measured lipid and liporotein parameters directly correlated with uricemia level, and inversely correlated with urate excretion rate, regardless of pathogenetic hyperuricemia mechanisms. Our results point to the fact that chronic hyperuricemia is assosiated with atherogenic lipid/lipoprotein phenotype, observed as early as in childhood, and possibly acts as an indicator of atherosclerosis risk. Therefore, use of a lower norm for population screening seems rational, from position of primary and secondary prevention of atherosclerosis. Our data support detailed examination of lipid metabolism if uricemia is higher than 0. 31 mmol/l.https://russjcardiol.elpub.ru/jour/article/view/1857chronic asymptomatic hyperuricemialiporotein profileatherogenic phenotypeatherosclerosis preventionadolescence |
| spellingShingle | S. I. Maljavskaya T. A. Toropygina V. E. Tril V. A. Ternovskaya Lipoprotein profile in girls with asymptomatic hyperuricemia Российский кардиологический журнал chronic asymptomatic hyperuricemia liporotein profile atherogenic phenotype atherosclerosis prevention adolescence |
| title | Lipoprotein profile in girls with asymptomatic hyperuricemia |
| title_full | Lipoprotein profile in girls with asymptomatic hyperuricemia |
| title_fullStr | Lipoprotein profile in girls with asymptomatic hyperuricemia |
| title_full_unstemmed | Lipoprotein profile in girls with asymptomatic hyperuricemia |
| title_short | Lipoprotein profile in girls with asymptomatic hyperuricemia |
| title_sort | lipoprotein profile in girls with asymptomatic hyperuricemia |
| topic | chronic asymptomatic hyperuricemia liporotein profile atherogenic phenotype atherosclerosis prevention adolescence |
| url | https://russjcardiol.elpub.ru/jour/article/view/1857 |
| work_keys_str_mv | AT simaljavskaya lipoproteinprofileingirlswithasymptomatichyperuricemia AT tatoropygina lipoproteinprofileingirlswithasymptomatichyperuricemia AT vetril lipoproteinprofileingirlswithasymptomatichyperuricemia AT vaternovskaya lipoproteinprofileingirlswithasymptomatichyperuricemia |