Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

Alzheimer’s disease-specific transcriptomic and epigenomic changes in the tryptophan catabolic pathway

Abstract Background Neurodegenerative disorders, including Alzheimer’s disease (AD), have been linked to alterations in tryptophan (TRP) metabolism. However, no studies to date have systematically explored changes in the TRP pathway at both transcriptional and epigenetic levels. This study aimed to...

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Main Authors: Kyonghwan Choe, Muhammad Ali, Roy Lardenoije, Renzo J.M. Riemens, Ehsan Pishva, Horst Bickel, Siegfried Weyerer, Per Hoffmann, Michael Pentzek, Steffi Riedel-Heller, Birgitt Wiese, Martin Scherer, Michael Wagner, Diego Mastroeni, Paul D. Coleman, Alfredo Ramirez, Inez H.G.B. Ramakers, Frans R.J. Verhey, Bart P.F. Rutten, Gunter Kenis, Daniel L.A. van den Hove
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Alzheimer’s Research & Therapy
Subjects:
Tryptophan (TRP)
Alzheimer’s disease (AD)
Epigenetics
Brain
Blood
Indoleamine 2,3-dioxygenase (IDO)
Online Access:https://doi.org/10.1186/s13195-024-01623-4
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https://doi.org/10.1186/s13195-024-01623-4

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