Royal Jelly and Its Dual Role in TNBS Colitis in Mice
Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Int...
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| Format: | Article |
| Language: | English |
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Wiley
2015-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2015/956235 |
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| author | Luis Paulo Manzo Felipe Meira de-Faria Ricardo José Dunder Eduardo Augusto Rabelo-Socca Silvio Roberto Consonni Ana Cristina Alves de Almeida Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira |
| author_facet | Luis Paulo Manzo Felipe Meira de-Faria Ricardo José Dunder Eduardo Augusto Rabelo-Socca Silvio Roberto Consonni Ana Cristina Alves de Almeida Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira |
| author_sort | Luis Paulo Manzo |
| collection | DOAJ |
| description | Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets. |
| format | Article |
| id | doaj-art-d7f164a23ea1484bb795f3823c9b5e0d |
| institution | Kabale University |
| issn | 2356-6140 1537-744X |
| language | English |
| publishDate | 2015-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d7f164a23ea1484bb795f3823c9b5e0d2025-02-03T01:12:56ZengWileyThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/956235956235Royal Jelly and Its Dual Role in TNBS Colitis in MiceLuis Paulo Manzo0Felipe Meira de-Faria1Ricardo José Dunder2Eduardo Augusto Rabelo-Socca3Silvio Roberto Consonni4Ana Cristina Alves de Almeida5Alba Regina Monteiro Souza-Brito6Anderson Luiz-Ferreira7Department of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Structural and Functional Biology, Institute of Biology, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Pharmacology, Faculty of Medical Sciences, University of Campinas (UNICAMP), 13083-970 Campinas, SP, BrazilDepartment of Biological Sciences, Federal University of Goiás (UFG), Regional Catalão, 75704-020 Catalão, GO, BrazilRoyal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.http://dx.doi.org/10.1155/2015/956235 |
| spellingShingle | Luis Paulo Manzo Felipe Meira de-Faria Ricardo José Dunder Eduardo Augusto Rabelo-Socca Silvio Roberto Consonni Ana Cristina Alves de Almeida Alba Regina Monteiro Souza-Brito Anderson Luiz-Ferreira Royal Jelly and Its Dual Role in TNBS Colitis in Mice The Scientific World Journal |
| title | Royal Jelly and Its Dual Role in TNBS Colitis in Mice |
| title_full | Royal Jelly and Its Dual Role in TNBS Colitis in Mice |
| title_fullStr | Royal Jelly and Its Dual Role in TNBS Colitis in Mice |
| title_full_unstemmed | Royal Jelly and Its Dual Role in TNBS Colitis in Mice |
| title_short | Royal Jelly and Its Dual Role in TNBS Colitis in Mice |
| title_sort | royal jelly and its dual role in tnbs colitis in mice |
| url | http://dx.doi.org/10.1155/2015/956235 |
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