Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation

Potential implications of granzyme B in keloids and hypertrophic scars through extracellular matrix remodeling and latent TGF-β activation

Keloid scars (KS) and hypertrophic scars (HS) are fibroproliferative wound healing defects characterized by excessive accumulation of extracellular matrix (ECM) in the dermis of affected individuals. Although transforming growth factor (TGF)-β is known to be involved in the formation of KS and HS, t...

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Bibliographic Details
Main Authors: Alexandre Aubert, Jenna Goeres, Amy Liu, Martin Kao, Katlyn C. Richardson, Karen Jung, Boris Hinz, Richard I. Crawford, David J. Granville
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Immunology
Subjects:
keloids
hypertrophic scars
granzymes
inflammation
extracellular matrix remodeling
TGF-β activation
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2024.1484462/full
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