T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis
Abstract Aims The aim of this study is to investigate the prognostic role of T1 mapping techniques in predicting major adverse cardiovascular events (MACE) in patients affected by non‐ischaemic dilated cardiomyopathy (NIDCM) by performing a meta‐analysis of available studies. Methods and results Dat...
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Wiley
2025-08-01
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| Series: | ESC Heart Failure |
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| Online Access: | https://doi.org/10.1002/ehf2.15279 |
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| author | Federico Marchini Beatrice Dal Passo Gianluca Campo Elisabetta Tonet Matteo Serenelli Alberto Cossu Serena Chiarello Maria Lo Monaco Erika Bertella Rita Pavasini |
| author_facet | Federico Marchini Beatrice Dal Passo Gianluca Campo Elisabetta Tonet Matteo Serenelli Alberto Cossu Serena Chiarello Maria Lo Monaco Erika Bertella Rita Pavasini |
| author_sort | Federico Marchini |
| collection | DOAJ |
| description | Abstract Aims The aim of this study is to investigate the prognostic role of T1 mapping techniques in predicting major adverse cardiovascular events (MACE) in patients affected by non‐ischaemic dilated cardiomyopathy (NIDCM) by performing a meta‐analysis of available studies. Methods and results Data from 12 observational studies exploring the prognostic role of native T1 mapping and extracellular volume (ECV) were analysed with random effect generic inverse variance. The primary endpoint was MACE defined as a composite of heart failure or arrhythmic‐related events, expressed as hazard ratio (HR) with 95% confidence interval (CI). Secondary main outcomes were heart failure‐related events, arrhythmic‐related events, and weighted mean difference of native T1 mapping values or ECVs between patients with or without MACE. Overall, 4025 patients with NIDCM were included. The median follow‐up length was 22 (IQR 14–22) months. The primary outcome of MACE occurred in 610 patients with a pooled HR for native T1 mapping values of 1.07 (95% CI 1.04–1.09, I2 31.5%) and a pooled HR for ECV of 1.37 (95% CI 1.29–1.44, I2 0%). HF‐related events occurred in 492 patients, with a pooled HR for T1 mapping of 1.05 (95% CI 1.03–1.07, I2 1%) and a pooled HR for ECVs of 1.43 (95% CI 1.25–1.61, I2 63%). Arrhythmic‐related events occurred in 118 patients, with a pooled HR for T1 mapping values of 1.09 (95% CI 1.07–1.12, I2 0%). The weighted mean difference of native T1 mapping between patients with and without MACE was 30.91 (95% CI 18.45–43.16, I2 16.72%), while the mean difference of ECV was 4.52 (95% CI 2.78–6.26, I2 86%). Conclusions In NIDCM patients, native T1 mapping and ECV were associated with increased risk of the composite primary endpoint of MACE and the secondary endpoint of heart failure and arrhythmic‐related events. |
| format | Article |
| id | doaj-art-d7e88fa1461a4deab7fc8ff5e66b1579 |
| institution | DOAJ |
| issn | 2055-5822 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley |
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| series | ESC Heart Failure |
| spelling | doaj-art-d7e88fa1461a4deab7fc8ff5e66b15792025-08-20T02:50:51ZengWileyESC Heart Failure2055-58222025-08-011242621263010.1002/ehf2.15279T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysisFederico Marchini0Beatrice Dal Passo1Gianluca Campo2Elisabetta Tonet3Matteo Serenelli4Alberto Cossu5Serena Chiarello6Maria Lo Monaco7Erika Bertella8Rita Pavasini9Cardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyCardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyCardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyCardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyCardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyDivision of Radiology Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyDivision of Radiology Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyCardio Center Humanitas Gavazzeni Bergamo ItalyCardio Center Humanitas Gavazzeni Bergamo ItalyCardiovascular Institute Azienda Ospedaliero Universitaria di Ferrara Ferrara ItalyAbstract Aims The aim of this study is to investigate the prognostic role of T1 mapping techniques in predicting major adverse cardiovascular events (MACE) in patients affected by non‐ischaemic dilated cardiomyopathy (NIDCM) by performing a meta‐analysis of available studies. Methods and results Data from 12 observational studies exploring the prognostic role of native T1 mapping and extracellular volume (ECV) were analysed with random effect generic inverse variance. The primary endpoint was MACE defined as a composite of heart failure or arrhythmic‐related events, expressed as hazard ratio (HR) with 95% confidence interval (CI). Secondary main outcomes were heart failure‐related events, arrhythmic‐related events, and weighted mean difference of native T1 mapping values or ECVs between patients with or without MACE. Overall, 4025 patients with NIDCM were included. The median follow‐up length was 22 (IQR 14–22) months. The primary outcome of MACE occurred in 610 patients with a pooled HR for native T1 mapping values of 1.07 (95% CI 1.04–1.09, I2 31.5%) and a pooled HR for ECV of 1.37 (95% CI 1.29–1.44, I2 0%). HF‐related events occurred in 492 patients, with a pooled HR for T1 mapping of 1.05 (95% CI 1.03–1.07, I2 1%) and a pooled HR for ECVs of 1.43 (95% CI 1.25–1.61, I2 63%). Arrhythmic‐related events occurred in 118 patients, with a pooled HR for T1 mapping values of 1.09 (95% CI 1.07–1.12, I2 0%). The weighted mean difference of native T1 mapping between patients with and without MACE was 30.91 (95% CI 18.45–43.16, I2 16.72%), while the mean difference of ECV was 4.52 (95% CI 2.78–6.26, I2 86%). Conclusions In NIDCM patients, native T1 mapping and ECV were associated with increased risk of the composite primary endpoint of MACE and the secondary endpoint of heart failure and arrhythmic‐related events.https://doi.org/10.1002/ehf2.15279Cardiovascular magnetic resonanceCMRECVMACENative T1 mappingNon‐ischaemic dilated cardiomyopathy |
| spellingShingle | Federico Marchini Beatrice Dal Passo Gianluca Campo Elisabetta Tonet Matteo Serenelli Alberto Cossu Serena Chiarello Maria Lo Monaco Erika Bertella Rita Pavasini T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis ESC Heart Failure Cardiovascular magnetic resonance CMR ECV MACE Native T1 mapping Non‐ischaemic dilated cardiomyopathy |
| title | T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis |
| title_full | T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis |
| title_fullStr | T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis |
| title_full_unstemmed | T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis |
| title_short | T1 mapping and major cardiovascular events in non‐ischaemic dilated cardiomyopathy: a systematic review and meta‐analysis |
| title_sort | t1 mapping and major cardiovascular events in non ischaemic dilated cardiomyopathy a systematic review and meta analysis |
| topic | Cardiovascular magnetic resonance CMR ECV MACE Native T1 mapping Non‐ischaemic dilated cardiomyopathy |
| url | https://doi.org/10.1002/ehf2.15279 |
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