Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study
Objectives: To assess the demographic and clinical characteristics, treatment and health outcome, and economic burden of juvenile-onset recurrent respiratory papillomatosis (JoRRP) in China. Methods: We identified twelve hospitals mainly responsible for JoRRP management across China to enroll patien...
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| Language: | English |
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Elsevier
2025-09-01
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| Series: | International Journal of Infectious Diseases |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1201971225001961 |
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| author | Changchang Dun Yutong Li Wenbin Lei Yun Li Hui Yang Yalikun Yasen Nilipaer Alimu Dapeng Lei Dongyan Chen Qingquan Hua Zhen Xu Zhe Zhang Guangke Wang Weiwei Wang Li Shi Xin Wang Xuelian Zhao Shangying Hu Xiaoguang Ni Jie Zhang Jun Wang Fanghui Zhao |
| author_facet | Changchang Dun Yutong Li Wenbin Lei Yun Li Hui Yang Yalikun Yasen Nilipaer Alimu Dapeng Lei Dongyan Chen Qingquan Hua Zhen Xu Zhe Zhang Guangke Wang Weiwei Wang Li Shi Xin Wang Xuelian Zhao Shangying Hu Xiaoguang Ni Jie Zhang Jun Wang Fanghui Zhao |
| author_sort | Changchang Dun |
| collection | DOAJ |
| description | Objectives: To assess the demographic and clinical characteristics, treatment and health outcome, and economic burden of juvenile-onset recurrent respiratory papillomatosis (JoRRP) in China. Methods: We identified twelve hospitals mainly responsible for JoRRP management across China to enroll patients presenting for JoRRP between Jan 1, 2011, and Dec 31, 2021. Data were primarily extracted from medical records, and missing values were additionally collected through telephone or outpatient interviews by two researchers independently. We used counts (proportions) and median values (interquartile range, IQR) to describe data. We applied the Lorenz curve and the concentration index (C-index) to indicate the wealth-related and education-related inequalities in JoRRP. Results: Of the 361 enrolled JoRRP patients, the median age at first diagnosis was 2.7 years (IQR: 1.5-5.0). During the 7.2-year median follow-up, we observed that 314 (87.0%) patients experienced relapse and 125 (38.0%) patients underwent an aggressive clinical course. The median value for the estimated total economic costs per patient was 8717.5$ (IQR: 4700.6$-15359.1$) and the occurrence of catastrophic health expenditure was concentrated in families with low incomes and less-educated parents. Conclusion: Chinese JoRRP patients experienced significant disease burden characterized by severe clinical symptoms and substantial economic costs. Strategic healthcare plans for JoRRP are needed for disease mitigation in China. |
| format | Article |
| id | doaj-art-d7e20bf2db494ff7b86d264fe9d3c282 |
| institution | DOAJ |
| issn | 1201-9712 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Infectious Diseases |
| spelling | doaj-art-d7e20bf2db494ff7b86d264fe9d3c2822025-08-20T03:18:38ZengElsevierInternational Journal of Infectious Diseases1201-97122025-09-0115810797210.1016/j.ijid.2025.107972Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide studyChangchang Dun0Yutong Li1Wenbin Lei2Yun Li3Hui Yang4Yalikun Yasen5Nilipaer Alimu6Dapeng Lei7Dongyan Chen8Qingquan Hua9Zhen Xu10Zhe Zhang11Guangke Wang12Weiwei Wang13Li Shi14Xin Wang15Xuelian Zhao16Shangying Hu17Xiaoguang Ni18Jie Zhang19Jun Wang20Fanghui Zhao21School of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, ChinaDepartment of Otorhinolaryngology, Head and Neck Surgery, Hunan Children’s Hospital, Changsha, ChinaDepartment of Otolaryngology-Head & Neck Surgery, West China Hospital of Sichuan University, Chengdu, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Otorhinolaryngology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang, ChinaDepartment of Otorhinolaryngology, Qilu Hospital of Shandong University, National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, ChinaDepartment of Otorhinolaryngology, Qilu Hospital of Shandong University, National Health Commission Key Laboratory of Otorhinolaryngology (Shandong University), Jinan, ChinaDepartment of Otolaryngology‐Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Otolaryngology‐Head and Neck Surgery, Renmin Hospital of Wuhan University, Wuhan, ChinaDepartment of Otolaryngology-Head and Neck Surgery, The First Affiliated Hospital of Guangxi Medical University, Nanning, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People’s Hospital; Zhengzhou University People’s Hospital, Zhengzhou, ChinaDepartment of Otorhinolaryngology Head and Neck Surgery, Henan Provincial People’s Hospital; Zhengzhou University People’s Hospital, Zhengzhou, ChinaDepartment of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi’an, ChinaDepartment of Otolaryngology, The First Hospital, Jilin University, Changchun, ChinaNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaNational Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, ChinaDepartment of Otolaryngology, Head and Neck Surgery, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing, ChinaDepartment of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Key Laboratory of Otolaryngology Head and Neck Surgery (Capital Medical University), Ministry of Education, Beijing, ChinaSchool of Population Medicine and Public Health, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China; Corresponding author: Fanghui Zhao, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100730, China.Objectives: To assess the demographic and clinical characteristics, treatment and health outcome, and economic burden of juvenile-onset recurrent respiratory papillomatosis (JoRRP) in China. Methods: We identified twelve hospitals mainly responsible for JoRRP management across China to enroll patients presenting for JoRRP between Jan 1, 2011, and Dec 31, 2021. Data were primarily extracted from medical records, and missing values were additionally collected through telephone or outpatient interviews by two researchers independently. We used counts (proportions) and median values (interquartile range, IQR) to describe data. We applied the Lorenz curve and the concentration index (C-index) to indicate the wealth-related and education-related inequalities in JoRRP. Results: Of the 361 enrolled JoRRP patients, the median age at first diagnosis was 2.7 years (IQR: 1.5-5.0). During the 7.2-year median follow-up, we observed that 314 (87.0%) patients experienced relapse and 125 (38.0%) patients underwent an aggressive clinical course. The median value for the estimated total economic costs per patient was 8717.5$ (IQR: 4700.6$-15359.1$) and the occurrence of catastrophic health expenditure was concentrated in families with low incomes and less-educated parents. Conclusion: Chinese JoRRP patients experienced significant disease burden characterized by severe clinical symptoms and substantial economic costs. Strategic healthcare plans for JoRRP are needed for disease mitigation in China.http://www.sciencedirect.com/science/article/pii/S1201971225001961Juvenile-onset recurrent respiratory papillomatosisHuman papillomavirusDisease characteristicsEconomic burdenHealth inequality |
| spellingShingle | Changchang Dun Yutong Li Wenbin Lei Yun Li Hui Yang Yalikun Yasen Nilipaer Alimu Dapeng Lei Dongyan Chen Qingquan Hua Zhen Xu Zhe Zhang Guangke Wang Weiwei Wang Li Shi Xin Wang Xuelian Zhao Shangying Hu Xiaoguang Ni Jie Zhang Jun Wang Fanghui Zhao Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study International Journal of Infectious Diseases Juvenile-onset recurrent respiratory papillomatosis Human papillomavirus Disease characteristics Economic burden Health inequality |
| title | Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study |
| title_full | Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study |
| title_fullStr | Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study |
| title_full_unstemmed | Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study |
| title_short | Characteristics of juvenile-onset recurrent respiratory papillomatosis in China, 2011-2021: A hospital-based nationwide study |
| title_sort | characteristics of juvenile onset recurrent respiratory papillomatosis in china 2011 2021 a hospital based nationwide study |
| topic | Juvenile-onset recurrent respiratory papillomatosis Human papillomavirus Disease characteristics Economic burden Health inequality |
| url | http://www.sciencedirect.com/science/article/pii/S1201971225001961 |
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