DECREASED CD10 EXPRESSION IN THE BONE MARROW NEUTROPHILS OF HIV POSITIVE PATIENTS
<p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Arial;"><strong style="mso-bidi-font-weight: normal;"...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
PAGEPress Publications
2010-08-01
|
| Series: | Mediterranean Journal of Hematology and Infectious Diseases |
| Subjects: | |
| Online Access: | http://www.mjhid.org/article/view/6473 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | <p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Arial;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US">Background: </span></strong><span lang="EN-US">HIV-1 infection is associated with various quantitative and qualitative changes in haemopoietic cells. Clear distinction between primary myelodysplastic syndrome (MDS) and secondary dysplasia may not always be possible. Adjunctive analyses used in the diagnosis of MDS include cytogenetics and flow cytometry (FCM). Much focus has been placed on establishing FCM guidelines aiding in the diagnosis of MDS, and to distinguish this condition from secondary dysplastic changes. One of the parameters often cited is the CD10 expression on the granulocyte population, as this marker denotes granulocytic maturation.</span></span></span><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US"><span style="font-family: Arial; font-size: small;"> </span></span></strong></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Arial;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US">Aims: </span></strong><span lang="EN-US">To determine the expression level of CD10 on granulocytes in HIV positive patients.</span></span></span><span lang="EN-US"><span style="font-family: Arial; font-size: small;"> </span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Arial;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US">Methods: </span></strong><span lang="EN-US">In total, 117 HIV-1 positive and 29 HIV-1 negative patients were included in this study. Bone marrow aspirate samples were evaluated in terms of morphological abnormality as well as CD10 expression on the granulocytic population.</span></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US"><span style="font-family: Arial; font-size: small;"> </span></span></strong><span style="font-size: small;"><span style="font-family: Arial;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US">Results:</span></strong><span lang="EN-US"> The average CD10 expression among the HIV-1 positive patients were markedly reduced, at 18.4%, and 113 patients (96.6%) of these patients had expression levels below 50%. </span></span></span></p><span style="font-size: small;"><span style="font-family: Arial;"><span lang="EN-US"><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><strong style="mso-bidi-font-weight: normal;"><span lang="EN-US">Discussion: </span></strong><span lang="EN-US">Disease conditions causing secondary dysplasia, especially HIV-1 infection, is associated with a marked reduction in CD10 expression on the granulocyte population independent from the presence of myelodysplastic features. This marker is therefore of doubtful significance as a diagnostic tool in distinguishing between primary and secondary dysplasia.</span></p></span></span></span><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span style="font-size: small;"><span style="font-family: Arial;"></span></span></p><p class="MsoNormal" style="text-align: justify; line-height: 200%; margin: 0cm 0cm 0pt;"><span lang="EN-US"><span style="font-family: Arial; font-size: small;"> </span></span></p><p> </p> |
|---|---|
| ISSN: | 2035-3006 |