Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan
Abstract HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in Taiwan using mostly integrase inhibito...
Saved in:
| Main Authors: | , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2025-02-01
|
| Series: | Scientific Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1038/s41598-025-88552-w |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823862345714106368 |
|---|---|
| author | Chien-An Tu Chien-Feng Kuo Chun-Ming Lee Chang-Pan Liu Hsiang-Kuang Tseng Tseng-Yu Huang Chih-Chen Lin Hsun Chang Winter Yu-Ning Lee Fang-Ju Sun Zu-Yi Sun Pei-Ching Lian Ming-Wei Cheng Alice Ying-Jung Wu |
| author_facet | Chien-An Tu Chien-Feng Kuo Chun-Ming Lee Chang-Pan Liu Hsiang-Kuang Tseng Tseng-Yu Huang Chih-Chen Lin Hsun Chang Winter Yu-Ning Lee Fang-Ju Sun Zu-Yi Sun Pei-Ching Lian Ming-Wei Cheng Alice Ying-Jung Wu |
| author_sort | Chien-An Tu |
| collection | DOAJ |
| description | Abstract HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in Taiwan using mostly integrase inhibitors-based regimen as HAART. A cross-sectional study involving all people living with HIV (PLWH) aged ≥ 18 years who visited MacKay Memorial Hospital, Taipei, Taiwan between September 7, 2022 to January 31, 2023 was performed. A modified National Cholesterol Education Program ATP III definition of metabolic syndrome was used to define metabolic syndrome and body mass index was used as surrogate for waist circumference. 809 PLWH participated in the study, in which 81.3% of patients were on integrase inhibitor-based HAART regimen. The prevalence of metabolic syndrome was 10.0%, which is markedly lower than those reported in the literature. Age was a significant risk factor for metabolic syndrome. HIV-related factors (CD4, viral load, HAART regimen) did not affect the presence of metabolic syndrome. Prevalence rate of metabolic syndrome appeared to have declined among PLWH compared to previous reports, possibly secondary to widespread use of integrase inhibitors. Age remains a strong risk factor for the development of metabolic syndrome among PLWH. |
| format | Article |
| id | doaj-art-d7df600c551b45eb8bb02e3f848da2a0 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d7df600c551b45eb8bb02e3f848da2a02025-02-09T12:34:39ZengNature PortfolioScientific Reports2045-23222025-02-011511810.1038/s41598-025-88552-wPrevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern TaiwanChien-An Tu0Chien-Feng Kuo1Chun-Ming Lee2Chang-Pan Liu3Hsiang-Kuang Tseng4Tseng-Yu Huang5Chih-Chen Lin6Hsun Chang7Winter Yu-Ning Lee8Fang-Ju Sun9Zu-Yi Sun10Pei-Ching Lian11Ming-Wei Cheng12Alice Ying-Jung Wu13Division of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, Cardinal Tien HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial Hospital Department of Medicine, MacKay Medical CollegeDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDepartment of Medical Research, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalDivision of Infectious Diseases, Department of Internal Medicine, MacKay Memorial HospitalAbstract HIV acquisition has been found to be associated with increased risk of cardiometabolic syndrome in the past. In this study, we attempt to delineate the associated factors of metabolic syndrome among persons living with HIV in a single medical center in Taiwan using mostly integrase inhibitors-based regimen as HAART. A cross-sectional study involving all people living with HIV (PLWH) aged ≥ 18 years who visited MacKay Memorial Hospital, Taipei, Taiwan between September 7, 2022 to January 31, 2023 was performed. A modified National Cholesterol Education Program ATP III definition of metabolic syndrome was used to define metabolic syndrome and body mass index was used as surrogate for waist circumference. 809 PLWH participated in the study, in which 81.3% of patients were on integrase inhibitor-based HAART regimen. The prevalence of metabolic syndrome was 10.0%, which is markedly lower than those reported in the literature. Age was a significant risk factor for metabolic syndrome. HIV-related factors (CD4, viral load, HAART regimen) did not affect the presence of metabolic syndrome. Prevalence rate of metabolic syndrome appeared to have declined among PLWH compared to previous reports, possibly secondary to widespread use of integrase inhibitors. Age remains a strong risk factor for the development of metabolic syndrome among PLWH.https://doi.org/10.1038/s41598-025-88552-wMetabolic syndromeHIVTaiwanHAARTIntegrase inhibitor |
| spellingShingle | Chien-An Tu Chien-Feng Kuo Chun-Ming Lee Chang-Pan Liu Hsiang-Kuang Tseng Tseng-Yu Huang Chih-Chen Lin Hsun Chang Winter Yu-Ning Lee Fang-Ju Sun Zu-Yi Sun Pei-Ching Lian Ming-Wei Cheng Alice Ying-Jung Wu Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan Scientific Reports Metabolic syndrome HIV Taiwan HAART Integrase inhibitor |
| title | Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan |
| title_full | Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan |
| title_fullStr | Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan |
| title_full_unstemmed | Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan |
| title_short | Prevalence and associated factors of metabolic syndrome among people living with HIV in a medical center of Northern Taiwan |
| title_sort | prevalence and associated factors of metabolic syndrome among people living with hiv in a medical center of northern taiwan |
| topic | Metabolic syndrome HIV Taiwan HAART Integrase inhibitor |
| url | https://doi.org/10.1038/s41598-025-88552-w |
| work_keys_str_mv | AT chienantu prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT chienfengkuo prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT chunminglee prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT changpanliu prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT hsiangkuangtseng prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT tsengyuhuang prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT chihchenlin prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT hsunchang prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT winteryuninglee prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT fangjusun prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT zuyisun prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT peichinglian prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT mingweicheng prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan AT aliceyingjungwu prevalenceandassociatedfactorsofmetabolicsyndromeamongpeoplelivingwithhivinamedicalcenterofnortherntaiwan |