Nano-based drug delivery systems for the treatment of non-infectious uveitis
Background: Uveitis is one of the most prevalent causes of global visual impairment. The current approaches to treating non-infectious uveitis (NIU) involve the utilization of corticosteroids, immunosuppressant and biologics agents. Nevertheless, the intricate ocular anatomy barriers and adverse sid...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-05-01
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| Series: | Advances in Ophthalmology Practice and Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2667376224000702 |
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| author | Xingdi Wu Mengyuan Hu Yilu Cai Fan Jia Yang Ye Naiji Yu Min Chen Kaijun Wang |
| author_facet | Xingdi Wu Mengyuan Hu Yilu Cai Fan Jia Yang Ye Naiji Yu Min Chen Kaijun Wang |
| author_sort | Xingdi Wu |
| collection | DOAJ |
| description | Background: Uveitis is one of the most prevalent causes of global visual impairment. The current approaches to treating non-infectious uveitis (NIU) involve the utilization of corticosteroids, immunosuppressant and biologics agents. Nevertheless, the intricate ocular anatomy barriers and adverse side effects of the drugs pose significant obstacles to effective treatment outcomes. Main text: To improve drug bioavailability and therapeutic outcomes for NIU while minimize side effects, researchers are committed to developing novel nano-based drug delivery systems (DDS), which have the capacity to achieve targeted delivery, increase bioavailability, achieve sustained release, reduce side effects and improve therapeutic effects. Thus, DDS based on nanotechnology, including liposome, dendrimer, hydrogels, nanoparticles, nanomicelles, nanosuspensions and nanoemulsions have emerged as promising alternatives to conventional ocular delivery methods for the management of NIU. Conclusions: In this review, we summarize the current therapeutic challenges faced by NIU and describe various nano-based intraocular DDS involved in the treatment of NIU. It is concluded that nano-based DDS is an appealing approach to addressing the unmet needs for the treatment of NIU. |
| format | Article |
| id | doaj-art-d7dec203f359462fa81f0560b7f40f1c |
| institution | DOAJ |
| issn | 2667-3762 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Advances in Ophthalmology Practice and Research |
| spelling | doaj-art-d7dec203f359462fa81f0560b7f40f1c2025-08-20T03:12:57ZengElsevierAdvances in Ophthalmology Practice and Research2667-37622025-05-015212413410.1016/j.aopr.2024.11.003Nano-based drug delivery systems for the treatment of non-infectious uveitisXingdi Wu0Mengyuan Hu1Yilu Cai2Fan Jia3Yang Ye4Naiji Yu5Min Chen6Kaijun Wang7Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, ChinaDepartment of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, ChinaZhejiang University School of Medicine, Hangzhou, ChinaMOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, China; Key Laboratory of Cardiovascular Intervention and Regenerative Medicine of Zhejiang Province, Department of Cardiology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, ChinaDepartment of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, ChinaDepartment of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, ChinaDepartment of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China; Corresponding author. Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China; Zhejiang Provincial Key Lab of Ophthalmology, Hangzhou, China; Corresponding author. Department of Ophthalmology, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, China.Background: Uveitis is one of the most prevalent causes of global visual impairment. The current approaches to treating non-infectious uveitis (NIU) involve the utilization of corticosteroids, immunosuppressant and biologics agents. Nevertheless, the intricate ocular anatomy barriers and adverse side effects of the drugs pose significant obstacles to effective treatment outcomes. Main text: To improve drug bioavailability and therapeutic outcomes for NIU while minimize side effects, researchers are committed to developing novel nano-based drug delivery systems (DDS), which have the capacity to achieve targeted delivery, increase bioavailability, achieve sustained release, reduce side effects and improve therapeutic effects. Thus, DDS based on nanotechnology, including liposome, dendrimer, hydrogels, nanoparticles, nanomicelles, nanosuspensions and nanoemulsions have emerged as promising alternatives to conventional ocular delivery methods for the management of NIU. Conclusions: In this review, we summarize the current therapeutic challenges faced by NIU and describe various nano-based intraocular DDS involved in the treatment of NIU. It is concluded that nano-based DDS is an appealing approach to addressing the unmet needs for the treatment of NIU.http://www.sciencedirect.com/science/article/pii/S2667376224000702Non-infectious uveitisOcular barriersDrug delivery systemsNanocarriersPharmacotherapy |
| spellingShingle | Xingdi Wu Mengyuan Hu Yilu Cai Fan Jia Yang Ye Naiji Yu Min Chen Kaijun Wang Nano-based drug delivery systems for the treatment of non-infectious uveitis Advances in Ophthalmology Practice and Research Non-infectious uveitis Ocular barriers Drug delivery systems Nanocarriers Pharmacotherapy |
| title | Nano-based drug delivery systems for the treatment of non-infectious uveitis |
| title_full | Nano-based drug delivery systems for the treatment of non-infectious uveitis |
| title_fullStr | Nano-based drug delivery systems for the treatment of non-infectious uveitis |
| title_full_unstemmed | Nano-based drug delivery systems for the treatment of non-infectious uveitis |
| title_short | Nano-based drug delivery systems for the treatment of non-infectious uveitis |
| title_sort | nano based drug delivery systems for the treatment of non infectious uveitis |
| topic | Non-infectious uveitis Ocular barriers Drug delivery systems Nanocarriers Pharmacotherapy |
| url | http://www.sciencedirect.com/science/article/pii/S2667376224000702 |
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