Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer
Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis of TOP2A from a pan-cancer perspective, despite its significance. A multiomics analysis was conducted to inv...
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Nature Portfolio
2025-02-01
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| Series: | Scientific Reports |
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| Online Access: | https://doi.org/10.1038/s41598-025-85929-9 |
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| author | Jin Zhang Tianxiao Yang Kenie Wang Jie Pan Junjun Qiu Shengnai Zheng Xuesong Li Guanghao Li |
| author_facet | Jin Zhang Tianxiao Yang Kenie Wang Jie Pan Junjun Qiu Shengnai Zheng Xuesong Li Guanghao Li |
| author_sort | Jin Zhang |
| collection | DOAJ |
| description | Abstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis of TOP2A from a pan-cancer perspective, despite its significance. A multiomics analysis was conducted to investigate TOP2A across various cancer types. This study involved the integration of over 10,000 multidimensional genomic datasets from 33 distinct cancer types, obtained from The Cancer Genome Atlas (TCGA). The analysis focused on evaluating the overall activity levels of TOP2A in pan-cancers, which encompassed differential expression, clinical significance, immune cell infiltration, and the regulation of pathways related to cancer. Aberrant epigenetic modifications and genomic alterations have been identified as being associated with the dysregulation of TOP2A expression levels. These molecular changes have substantial impacts on cancer progression, intratumoral heterogeneity, immunological status, and the regulation of pathways related to cancer biomarkers. Consequently, patient prognosis varies significantly based on the presence and specific nature of these alterations. The potential of TOP2A to serve as a novel biomarker for prognosis may offer valuable insights into the diagnosis and treatment of cancer. |
| format | Article |
| id | doaj-art-d7dd9bb8fc8f4484afa1974ccdb00104 |
| institution | DOAJ |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-d7dd9bb8fc8f4484afa1974ccdb001042025-08-20T03:10:57ZengNature PortfolioScientific Reports2045-23222025-02-0115111410.1038/s41598-025-85929-9Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancerJin Zhang0Tianxiao Yang1Kenie Wang2Jie Pan3Junjun Qiu4Shengnai Zheng5Xuesong Li6Guanghao Li7Department of Orthopedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Orthopedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical UniversityThe First Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for CancerDepartment of Spine, Shanghai East HospitalDepartment of Orthopedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Orthopedic Surgery, Institute of Digital Medicine, Nanjing First Hospital, Nanjing Medical UniversityDepartment of Pediatric Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesDepartment of Urology, Shandong Cancer Hospital and Institute, Shandong First Medical University, Shandong Academy of Medical SciencesAbstract Topoisomerases are critical nuclear enzymes that resolve DNA topological challenges during genetic processes. However, there is currently a lack of comprehensive multi-omics analysis of TOP2A from a pan-cancer perspective, despite its significance. A multiomics analysis was conducted to investigate TOP2A across various cancer types. This study involved the integration of over 10,000 multidimensional genomic datasets from 33 distinct cancer types, obtained from The Cancer Genome Atlas (TCGA). The analysis focused on evaluating the overall activity levels of TOP2A in pan-cancers, which encompassed differential expression, clinical significance, immune cell infiltration, and the regulation of pathways related to cancer. Aberrant epigenetic modifications and genomic alterations have been identified as being associated with the dysregulation of TOP2A expression levels. These molecular changes have substantial impacts on cancer progression, intratumoral heterogeneity, immunological status, and the regulation of pathways related to cancer biomarkers. Consequently, patient prognosis varies significantly based on the presence and specific nature of these alterations. The potential of TOP2A to serve as a novel biomarker for prognosis may offer valuable insights into the diagnosis and treatment of cancer.https://doi.org/10.1038/s41598-025-85929-9TCGAImmune microenvironmentTOP2AImmune checkpointsImmunotherapy |
| spellingShingle | Jin Zhang Tianxiao Yang Kenie Wang Jie Pan Junjun Qiu Shengnai Zheng Xuesong Li Guanghao Li Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer Scientific Reports TCGA Immune microenvironment TOP2A Immune checkpoints Immunotherapy |
| title | Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer |
| title_full | Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer |
| title_fullStr | Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer |
| title_full_unstemmed | Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer |
| title_short | Multi-omics analysis reveals the panoramic picture of TOP2A in pan-cancer |
| title_sort | multi omics analysis reveals the panoramic picture of top2a in pan cancer |
| topic | TCGA Immune microenvironment TOP2A Immune checkpoints Immunotherapy |
| url | https://doi.org/10.1038/s41598-025-85929-9 |
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